KEGG   DRUG: Thiethylperazine
Entry
D02354                      Drug                                   
Name
Thiethylperazine (USAN/INN)
Formula
C22H29N3S2
Exact mass
399.1803
Mol weight
399.6158
Structure
Simcomp
Class
Neuropsychiatric agent
 DG03200  Antipsychotic agent
  DG01905  Phenothiazine antipsychotics
Remark
Same as: C07132
ATC code: R06AD03
Chemical structure group: DG01102
Efficacy
Anti-emetic, Antipsychotic, Dopamine D2 receptor antagonist
Comment
Phenothiazine derivative
Target
DRD2 [HSA:1813] [KO:K04145]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04728  Dopaminergic synapse
Interaction
Structure map
map07029  Antipsychotics - phenothiazines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AD Phenothiazine derivatives
     R06AD03 Thiethylperazine
      D02354  Thiethylperazine (USAN/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG03200  Antipsychotic agent
   DG01905  Phenothiazine antipsychotics
    DG01102  Thiethylperazine
     D02354  Thiethylperazine
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D02354  Thiethylperazine (USAN/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG03200  Antipsychotic agent
   DG01905  Phenothiazine antipsychotics
    DG01102  Thiethylperazine
Other DBs
CAS: 1420-55-9
PubChem: 7849413
ChEBI: 9544
LigandBox: D02354
NIKKAJI: J3.667F
KCF data

ATOM        27
            1   C8y C    28.6440  -19.9600
            2   N1y N    29.8570  -19.2568
            3   C8y C    28.6440  -21.3490
            4   C8x C    27.4310  -19.2568
            5   C8y C    31.0642  -19.9600
            6   S2x S    29.8570  -22.0579
            7   C8x C    27.4310  -22.0579
            8   C8x C    26.2179  -19.9600
            9   C8y C    31.0642  -21.3490
            10  C8x C    32.2714  -19.2568
            11  C8x C    26.2179  -21.3490
            12  C8x C    32.2714  -22.0579
            13  C8y C    33.4785  -19.9600
            14  C8x C    33.4785  -21.3490
            15  S2a S    34.6953  -19.2606
            16  C1b C    35.9177  -19.9698
            17  C1a C    37.1220  -19.2783
            18  C1b C    29.8580  -17.8253
            19  C1b C    31.0922  -17.1137
            20  C1b C    32.2806  -17.8001
            21  N1y N    33.4938  -17.1000
            22  C1x C    34.6721  -17.7806
            23  C1x C    35.8847  -17.0809
            24  N1y N    35.8849  -15.6809
            25  C1x C    34.7066  -15.0003
            26  C1x C    33.4941  -15.7000
            27  C1a C    37.1166  -14.9699
BOND        30
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     3   7 1
            7     4   8 2
            8     5   9 2
            9     5  10 1
            10    7  11 2
            11    9  12 1
            12   10  13 2
            13   12  14 2
            14    6   9 1
            15    8  11 1
            16   13  14 1
            17   13  15 1
            18   15  16 1
            19   16  17 1
            20    2  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   21  22 1
            25   22  23 1
            26   23  24 1
            27   24  25 1
            28   25  26 1
            29   21  26 1
            30   24  27 1

» Japanese version   » Back

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Drug (2)   
   KEGG DGROUP (1)   
   LigandBox (1)   
Chemical substance (6)   
   KEGG COMPOUND (1)   
   PubChem (1)   
   ChEBI (1)   
   HMDB (1)   
   HSDB (1)   
   NIKKAJI (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
All databases (14)   

Download RDF
KEGG   DRUG: Thiethylperazine maleate
Entry
D01130                      Drug                                   
Name
Thiethylperazine maleate (JAN/USP);
Norzine (TN)
Formula
C22H29N3S2. (C4H4O4)2
Exact mass
631.2022
Mol weight
631.7601
Structure
Simcomp
Class
Neuropsychiatric agent
 DG03200  Antipsychotic agent
  DG01905  Phenothiazine antipsychotics
Remark
ATC code: R06AD03
Chemical structure group: DG01102
Efficacy
Anti-emetic, Antipsychotic, Dopamine D2 receptor antagonist
Comment
Phenothiazine derivative
Target
DRD2 [HSA:1813] [KO:K04145]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04728  Dopaminergic synapse
Interaction
Structure map
map07029  Antipsychotics - phenothiazines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AD Phenothiazine derivatives
     R06AD03 Thiethylperazine
      D01130  Thiethylperazine maleate (JAN/USP)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG03200  Antipsychotic agent
   DG01905  Phenothiazine antipsychotics
    DG01102  Thiethylperazine
     D01130  Thiethylperazine maleate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D01130  Thiethylperazine maleate (JAN/USP)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG03200  Antipsychotic agent
   DG01905  Phenothiazine antipsychotics
    DG01102  Thiethylperazine
Other DBs
CAS: 1179-69-7
PubChem: 7848193
ChEBI: 32216
LigandBox: D01130
NIKKAJI: J473.072K
KCF data

ATOM        43
            1   C6a C    40.5832  -20.1140
            2   C2b C    39.9323  -18.9911
            3   O6a O    39.9382  -21.3127
            4   O6a O    41.8853  -20.1079
            5   C2b C    38.2335  -18.9970
            6   C6a C    37.5885  -20.1258
            7   O6a O    36.2863  -20.1258
            8   O6a O    38.2454  -21.2486
            9   C8y C    23.6600  -21.2800
            10  N1y N    24.8500  -20.5100
            11  C8y C    23.6600  -22.6100
            12  C8x C    22.4000  -20.5100
            13  C8y C    26.0400  -21.2800
            14  S2x S    24.8500  -23.3800
            15  C8x C    22.4000  -23.3800
            16  C8x C    21.2100  -21.2800
            17  C8y C    26.0400  -22.6100
            18  C8x C    27.3000  -20.5100
            19  C8x C    21.2100  -22.6100
            20  C8x C    27.3000  -23.3800
            21  C8y C    28.4900  -21.2800
            22  C8x C    28.4900  -22.6100
            23  S2a S    29.6800  -20.5800
            24  C1b C    30.9400  -21.2800
            25  C1a C    32.1300  -20.5800
            26  C1b C    24.8500  -19.1100
            27  C1b C    26.1100  -18.4100
            28  C1b C    27.3000  -19.1100
            29  N1y N    28.4900  -18.4100
            30  C1x C    29.6800  -19.0400
            31  C1x C    30.8700  -18.3400
            32  N1y N    30.8700  -16.9400
            33  C1x C    29.6800  -16.3100
            34  C1x C    28.4900  -17.0100
            35  C1a C    32.1300  -16.2400
            36  C6a C    40.5832  -20.1140
            37  C2b C    39.9323  -18.9911
            38  C2b C    38.2335  -18.9970
            39  C6a C    37.5885  -20.1258
            40  O6a O    36.2863  -20.1258
            41  O6a O    38.2454  -21.2486
            42  O6a O    39.9382  -21.3127
            43  O6a O    41.8853  -20.1079
BOND        44
            1     9  10 1
            2     9  11 2
            3     9  12 1
            4    10  13 1
            5    11  14 1
            6    11  15 1
            7    12  16 2
            8    13  17 2
            9    13  18 1
            10   15  19 2
            11   17  20 1
            12   18  21 2
            13   20  22 2
            14   14  17 1
            15   16  19 1
            16   21  22 1
            17   21  23 1
            18   23  24 1
            19   24  25 1
            20   10  26 1
            21   26  27 1
            22   27  28 1
            23   28  29 1
            24   29  30 1
            25   30  31 1
            26   31  32 1
            27   32  33 1
            28   33  34 1
            29   29  34 1
            30   32  35 1
            31    6   7 1
            32    6   8 2
            33    1   2 1
            34    1   3 1
            35    1   4 2
            36    2   5 2
            37    5   6 1
            38   39  40 1
            39   39  41 2
            40   36  37 1
            41   36  42 1
            42   36  43 2
            43   37  38 2
            44   38  39 1
BRACKET     1    34.5800  -21.9800   34.5800  -18.4100
            1    42.9100  -18.4100   42.9100  -21.9800
            1  2
 ORIGINAL  1    1   2   5   6   7   8   3   4
 REPEAT    1   36  37  38  39  40  41  42  43

» Japanese version   » Back

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Drug (2)   
   KEGG DGROUP (1)   
   LigandBox (1)   
Chemical substance (3)   
   PubChem (1)   
   ChEBI (1)   
   NIKKAJI (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
All databases (11)   

Download RDF
KEGG   DRUG: Thiethylperazine malate
Entry
D02610                      Drug                                   
Name
Thiethylperazine malate (JAN);
Torecan (TN)
Formula
C22H29N3S2. (C4H6O5)2
Exact mass
667.2233
Mol weight
667.7906
Structure
Simcomp
Class
Neuropsychiatric agent
 DG03200  Antipsychotic agent
  DG01905  Phenothiazine antipsychotics
Remark
ATC code: R06AD03
Chemical structure group: DG01102
Efficacy
Anti-emetic, Antipsychotic, Antivertigo, Dopamine D2 receptor antagonist
Comment
Phenothiazine derivative
Target
DRD2 [HSA:1813] [KO:K04145]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04728  Dopaminergic synapse
Interaction
Structure map
map07029  Antipsychotics - phenothiazines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AD Phenothiazine derivatives
     R06AD03 Thiethylperazine
      D02610  Thiethylperazine malate (JAN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG03200  Antipsychotic agent
   DG01905  Phenothiazine antipsychotics
    DG01102  Thiethylperazine
     D02610  Thiethylperazine malate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D02610  Thiethylperazine malate (JAN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG03200  Antipsychotic agent
   DG01905  Phenothiazine antipsychotics
    DG01102  Thiethylperazine
Other DBs
CAS: 52239-63-1
PubChem: 17396780
LigandBox: D02610
NIKKAJI: J244.403H
KCF data

ATOM        45
            1   O6a O    35.4200  -19.1100
            2   C6a C    36.6324  -19.8100
            3   C1c C    37.8449  -19.1100
            4   C1b C    39.0573  -19.8100
            5   C6a C    40.2697  -19.1100
            6   O6a O    41.4822  -19.8100
            7   O6a O    36.6324  -21.2098
            8   O6a O    40.2697  -17.7101
            9   O1a O    37.8449  -17.7102
            10  C8y C    23.2400  -19.9500
            11  N1y N    24.4300  -19.1800
            12  C8y C    23.2400  -21.2800
            13  C8x C    21.9800  -19.1800
            14  C8y C    25.6200  -19.9500
            15  S2x S    24.4300  -22.0500
            16  C8x C    21.9800  -22.0500
            17  C8x C    20.7900  -19.9500
            18  C8y C    25.6200  -21.2800
            19  C8x C    26.8800  -19.1800
            20  C8x C    20.7900  -21.2800
            21  C8x C    26.8800  -22.0500
            22  C8y C    28.0700  -19.9500
            23  C8x C    28.0700  -21.2800
            24  S2a S    29.2600  -19.2500
            25  C1b C    30.5200  -19.9500
            26  C1a C    31.7100  -19.2500
            27  C1b C    24.4300  -17.7800
            28  C1b C    25.6900  -17.0800
            29  C1b C    26.8800  -17.7800
            30  N1y N    28.0700  -17.0800
            31  C1x C    29.2600  -17.7100
            32  C1x C    30.4500  -17.0100
            33  N1y N    30.4500  -15.6100
            34  C1x C    29.2600  -14.9800
            35  C1x C    28.0700  -15.6800
            36  C1a C    31.7100  -14.9100
            37  O6a O    35.4200  -19.1100
            38  C6a C    36.6324  -19.8100
            39  C1c C    37.8449  -19.1100
            40  C1b C    39.0573  -19.8100
            41  C6a C    40.2697  -19.1100
            42  O6a O    41.4822  -19.8100
            43  O6a O    40.2697  -17.7101
            44  O1a O    37.8449  -17.7102
            45  O6a O    36.6324  -21.2098
BOND        46
            1    10  11 1
            2    10  12 2
            3    10  13 1
            4    11  14 1
            5    12  15 1
            6    12  16 1
            7    13  17 2
            8    14  18 2
            9    14  19 1
            10   16  20 2
            11   18  21 1
            12   19  22 2
            13   21  23 2
            14   15  18 1
            15   17  20 1
            16   22  23 1
            17   22  24 1
            18   24  25 1
            19   25  26 1
            20   11  27 1
            21   27  28 1
            22   28  29 1
            23   29  30 1
            24   30  31 1
            25   31  32 1
            26   32  33 1
            27   33  34 1
            28   34  35 1
            29   30  35 1
            30   33  36 1
            31    1   2 1
            32    2   3 1
            33    3   4 1
            34    4   5 1
            35    5   6 1
            36    2   7 2
            37    5   8 2
            38    3   9 1
            39   37  38 1
            40   38  39 1
            41   39  40 1
            42   40  41 1
            43   41  42 1
            44   38  45 2
            45   41  43 2
            46   39  44 1
BRACKET     1    33.9500  -22.1900   33.9500  -16.1700
            1    42.9100  -16.1700   42.9100  -22.1900
            1  2
 ORIGINAL  1    1   2   3   4   5   6   8   9   7
 REPEAT    1   37  38  39  40  41  42  43  44  45

» Japanese version   » Back

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Drug (2)   
   KEGG DGROUP (1)   
   LigandBox (1)   
Chemical substance (2)   
   PubChem (1)   
   NIKKAJI (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
All databases (10)   

Download RDF
DBGET integrated database retrieval system