KEGG   DRUG: ProgesteroneHelp
Entry
D00066                      Drug                                   

Name
Progesterone (JP17/USP/INN);
Crinone (TN);
Prometrium (TN)
Product
  Generic
Formula
C21H30O2
Exact mass
314.2246
Mol weight
314.4617
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Other
 DG01666  Progesterone receptor agonist
Cyp substrate
 DG01639  CYP2C19 substrate
 DG01633  CYP3A4 substrate
Remark
Same as: 
Therapeutic category: 
ATC code: 
Activity
Progestin
Target
progesterone receptor agonist [HSA:5241] [KO:K08556]
  Pathway
Oocyte meiosis
Progesterone-mediated oocyte maturation
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP2C19 [HSA:1557]
Interaction
Drug interaction
Structure map
Glucocorticoid and meneralocorticoid receptor agonists/antagonists
Progesterone, androgen and estrogen receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03D PROGESTOGENS
    G03DA Pregnen (4) derivatives
     G03DA04 Progesterone
      D00066  Progesterone (JP17/USP/INN)
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Sex Hormones/Modifiers)
  Progestins
   Progesterone
    D00066  Progesterone (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   247  Estrogen and progesterone preparations
    2477  Progesterones
     D00066  Progesterone (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    progesterone receptor
     Progesterone
      D00066  Progesterone (JP17/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP2C19
   Progesterone
    D00066  Progesterone (JP17/USP/INN)
  CYP3A4
   Progesterone
    D00066  Progesterone (JP17/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00066  Progesterone
  D00066  Progesterone injection
Endocrine and hormonal agents [br08373.html]
 Hormone related agents
  D00066
 Other gynecological agents
  D00066
BRITE hierarchy
Other DBs
CAS: 
57-83-0
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        23
            1   C1y C    23.0350  -18.9936
            2   C1y C    24.2088  -19.6769
            3   C1z C    21.8554  -19.6827
            4   C1x C    23.0233  -17.6271
            5   C1y C    25.4002  -18.9819
            6   C1x C    24.1913  -21.0784
            7   C2y C    21.8554  -21.0375
            8   C1x C    20.6873  -19.0112
            9   C1a C    21.8437  -18.2754
            10  C1x C    24.2030  -16.9322
            11  C1z C    25.4060  -17.6097
            12  C1x C    27.7653  -18.9936
            13  C1x C    23.0409  -21.7092
            14  C2x C    20.6873  -21.7150
            15  C1x C    19.5194  -19.6827
            16  C1y C    26.5974  -16.9263
            17  C1a C    25.3943  -16.2081
            18  C1x C    27.7712  -17.6213
            19  C5x C    19.5194  -21.0375
            20  C5a C    26.6032  -15.5948
            21  O5x O    18.3690  -21.6975
            22  C1a C    25.3885  -14.8823
            23  O5a O    27.8121  -14.8882
BOND        26
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     3   9 1 #Up
            9     4  10 1
            10    5  11 1
            11    5  12 1
            12    6  13 1
            13    7  14 2
            14    8  15 1
            15   11  16 1
            16   11  17 1 #Up
            17   12  18 1
            18   14  19 1
            19   16  20 1 #Up
            20   19  21 2
            21   20  22 1
            22   20  23 2
            23    7  13 1
            24   10  11 1
            25   15  19 1
            26   16  18 1

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