 | | DRUG: Tretinoin | |
| Entry |
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| Name |
Tretinoin (JAN/USP/INN);
Avita (TN);
Renova (TN);
Retin A (TN);
Tretinoin (TN) |
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| Product |
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| Generic |
TRETINOIN (A-S Medication Solutions), TRETINOIN (A-S Medication Solutions), TRETINOIN (A-S Medication Solutions), TRETINOIN (Actavis Pharma), TRETINOIN (American Health Packaging), TRETINOIN (AvKARE), TRETINOIN (Bryant Ranch Prepack), TRETINOIN (Bryant Ranch Prepack), TRETINOIN (Bryant Ranch Prepack), TRETINOIN (Bryant Ranch Prepack), TRETINOIN (Bryant Ranch Prepack), TRETINOIN (Bryant Ranch Prepack), TRETINOIN (Bryant Ranch Prepack), TRETINOIN (Encube Ethicals Private Limited), TRETINOIN (Glenmark Pharmaceuticals), TRETINOIN (H2-Pharma), TRETINOIN (Major Pharmaceuticals), TRETINOIN (Mylan Pharmaceuticals), TRETINOIN (Mylan Pharmaceuticals), TRETINOIN (Mylan Pharmaceuticals), TRETINOIN (NORTHSTAR RX LLC), TRETINOIN (NORTHSTAR RX LLC), TRETINOIN (NuCare Pharmaceuticals), TRETINOIN (Obagi Cosmeceuticals LLC), TRETINOIN (Oceanside Pharmaceuticals), TRETINOIN (Oceanside Pharmaceuticals), TRETINOIN (Padagis US LLC), TRETINOIN (Par Pharmaceutical), TRETINOIN (REMEDYREPACK), TRETINOIN (RPK Pharmaceuticals), TRETINOIN (Taro Pharmaceuticals U.S.A.), TRETINOIN (Taro Pharmaceuticals U.S.A.), TRETINOIN (Taro Pharmaceuticals U.S.A.), TRETINOIN (Teva Pharmaceuticals USA) |
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| Formula |
C20H28O2
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| Exact mass |
300.2089
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| Mol weight |
300.4351
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| Structure |
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| Simcomp |
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| Class |
Vitamin and mineral
DG01604 Retinol derivative
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| Remark |
| Therapeutic category: | 4291 |
| Product (DG00433): | D00094<JP/US> D01516<JP> |
| Product (mixture): | D11084<US> D12338<US> D12499<US> |
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| Efficacy |
Antineoplastic, Keratolytic, Retinoic acid receptor (RAR) agonist |
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| Disease |
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| Comment |
Vesanoid (TN): discontinued in FDA
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| Target |
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| Pathway |
| hsa05202 | Transcriptional misregulation in cancer |
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| Interaction |
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| Structure map |
| map07223 | Retinoic acid receptor (RAR) and retinoid X receptor (RXR) agonists/antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D10 ANTI-ACNE PREPARATIONS
D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
D10AD Retinoids for topical use in acne
D10AD01 Tretinoin
D00094 Tretinoin (JAN/USP/INN) <JP/US>
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01X OTHER ANTINEOPLASTIC AGENTS
L01XF Retinoids for cancer treatment
L01XF01 Tretinoin
D00094 Tretinoin (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Antineoplastics
Retinoids
Tretinoin
D00094 Tretinoin (JAN/USP/INN)
Dermatological Agents
Acne and Rosacea Agents
Retinoids
Tretinoin
D00094 Tretinoin (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
4 Agents affecting cellular function
42 Antineoplastics
429 Miscellaneous
4291 Other Antitumors
D00094 Tretinoin (JAN/USP/INN)
Drug groups [BR:br08330]
Vitamin and mineral
DG01604 Retinol derivative
DG00433 Tretinoin
D00094 Tretinoin
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Thyroid hormone like receptors
Retinoic acid receptor (RAR)
NR1B (RAR)
D00094 Tretinoin (JAN/USP/INN) <JP/US>
PML-RARA
D00094 Tretinoin (JAN/USP/INN) <JP/US>
Drug groups [BR:br08330]
Vitamin and mineral
DG01604 Retinol derivative
DG00433 Tretinoin
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| Other DBs |
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| KCF data |
ATOM 22
1 C1x C 14.4200 -19.8100
2 C1x C 14.4200 -21.2100
3 C1x C 15.6324 -21.9100
4 C2y C 16.8449 -21.2100
5 C2y C 16.8449 -19.8100
6 C1z C 15.6324 -19.1100
7 C1a C 16.4540 -17.9930
8 C1a C 14.6889 -18.0557
9 C1a C 18.0760 -21.9210
10 C2b C 18.0760 -19.0990
11 C2b C 19.2812 -19.7947
12 C2c C 20.4635 -19.1119
13 C2b C 21.6575 -19.8012
14 C1a C 20.4635 -17.7102
15 C2b C 22.8454 -19.1152
16 C2b C 24.0365 -19.8029
17 C2c C 25.2259 -19.1161
18 C2b C 26.4162 -19.8034
19 C6a C 27.6061 -19.1163
20 O6a O 28.7962 -19.8035
21 C1a C 25.2260 -17.7102
22 O6a O 27.6061 -17.7102
BOND 22
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 2
5 5 6 1
6 1 6 1
7 6 7 1
8 6 8 1
9 4 9 1
10 5 10 1
11 10 11 2
12 11 12 1
13 12 13 2
14 12 14 1
15 13 15 1
16 15 16 2
17 16 17 1
18 17 18 2
19 18 19 1
20 19 20 1
21 17 21 1
22 19 22 2
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