KEGG   DRUG: CalcitriolHelp
Entry
D00129                      Drug                                   

Name
Calcitriol (JAN/USP/INN);
Rocaltrol (TN)
Product
  Generic
CALCITRIOL (Akorn), CALCITRIOL (Akorn), CALCITRIOL (American Health Packaging), CALCITRIOL (American Regent), CALCITRIOL (Aphena Pharma Solutions - Tennessee), CALCITRIOL (Aphena Pharma Solutions - Tennessee), CALCITRIOL (Aphena Pharma Solutions - Tennessee), CALCITRIOL (Cardinal Health), CALCITRIOL (Carilion Materials Management), CALCITRIOL (Dispensing Solutions), CALCITRIOL (Fresenius Kabi USA), CALCITRIOL (Golden State Medical Supply), CALCITRIOL (Heritage Pharmaceuticals), CALCITRIOL (KAISER FOUNDATION HOSPITALS), CALCITRIOL (Physicians Total Care), CALCITRIOL (Physicians Total Care), CALCITRIOL (Ranbaxy Pharmaceuticals), CALCITRIOL (Teva Pharmaceuticals USA), CALCITRIOL (Teva Pharmaceuticals USA), CALCITRIOL (West-Ward Pharmaceuticals Corp.), CALCITRIOL (West-Ward Pharmaceuticals Corp.), CALCITRIOL (West-ward Pharmaceutical Corp), CALCITRIOL (Strides Arcolab Limited)
Formula
C27H44O3
Exact mass
416.329
Mol weight
416.6365
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Other
 DG01607  Vitamin D derivatives
  DG01606  Activated vitamin D3
Remark
Same as: 
Therapeutic category: 
ATC code: 
Activity
Osteoporosis agent, Vitamin D receptor agonist
Comment
Vitamine D3 analogue
Target
NR1I1 (VDR) [HSA:7421] [KO:K08539]
  Pathway
Endocrine and other factor-regulated calcium reabsorption
Mineral absorption
Interaction
Drug interaction
Structure map
Osteoporosis drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A11 VITAMINS
   A11C VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO
    A11CC Vitamin D and analogues
     A11CC04 Calcitriol
      D00129  Calcitriol (JAN/USP/INN)
 D DERMATOLOGICALS
  D05 ANTIPSORIATICS
   D05A ANTIPSORIATICS FOR TOPICAL USE
    D05AX Other antipsoriatics for topical use
     D05AX03 Calcitriol
      D00129  Calcitriol (JAN/USP/INN)
USP drug classification [BR:br08302]
 Dermatological Agents
  Calcitriol
   D00129  Calcitriol (JAN/USP/INN)
 Metabolic Bone Disease Agents
  Calcitriol
   D00129  Calcitriol (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  31  Vitamins
   311  Vitamins A and D preparations
    3112  Synthetic vitamin D preparations
     D00129  Calcitriol (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Thyroid hormone like receptors
   Vitamin D3 like receptor
    vitamin D receptor
     Calcitriol
      D00129  Calcitriol (JAN/USP/INN)
Osteoporosis drugs [br08368.html]
 D00129
Rx-to-OTC switch list in Japan [br08314.html]
 D00129
BRITE hierarchy
Other DBs
CAS: 
32222-06-3
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        30
            1   C1x C    21.2800  -22.4000
            2   C1x C    21.2800  -23.8000
            3   C2y C    22.4924  -24.5000
            4   C1y C    23.7049  -23.8000
            5   C1z C    23.7049  -22.4000
            6   C1x C    22.4924  -21.7000
            7   C1x C    25.0364  -24.2326
            8   C1x C    25.8593  -23.1000
            9   C1y C    25.0364  -21.9674
            10  C1a C    23.7049  -21.0000
            11  C2b C    22.4924  -25.8998
            12  C2b C    21.2632  -26.6097
            13  C2y C    21.2632  -28.0097
            14  C1x C    20.0676  -28.7000
            15  C1y C    20.0676  -30.1000
            16  C1x C    21.2800  -30.8000
            17  C1y C    22.4756  -30.1097
            18  C2y C    22.4756  -28.7097
            19  C2a C    23.6880  -28.0097
            20  O1a O    23.6797  -30.8048
            21  O1a O    18.8721  -30.7904
            22  C1c C    25.4675  -20.6406
            23  C1b C    26.8675  -20.6406
            24  C1a C    24.6535  -19.5200
            25  C1b C    27.5666  -19.4299
            26  C1b C    28.9797  -19.4297
            27  C1d C    29.6665  -18.2399
            28  O1a O    31.0797  -18.2395
            29  C1a C    28.9827  -17.0560
            30  C1a C    30.3832  -19.4806
BOND        32
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    5   9 1
            11    5  10 1 #Up
            12    3  11 2
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   13  18 1
            21   18  19 2
            22   17  20 1 #Up
            23   15  21 1 #Down
            24    9  22 1
            25   22  23 1
            26   22  24 1 #Down
            27   23  25 1
            28   25  26 1
            29   26  27 1
            30   27  28 1
            31   27  29 1
            32   27  30 1

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