KEGG   DRUG: TorsemideHelp
Entry
D00382                      Drug                                   

Name
Torsemide (USP);
Torasemide (JAN/INN);
Demadex (TN);
Luprac (TN)
Product
  Generic
TORSEMIDE (American Health Packaging), TORSEMIDE (American Regent), TORSEMIDE (Apotex Corp.), TORSEMIDE (Aurobindo Pharma Limited), TORSEMIDE (AvKARE), TORSEMIDE (AvPAK), TORSEMIDE (Avera McKennan Hospital), TORSEMIDE (Bryant Ranch Prepack), TORSEMIDE (Bryant Ranch Prepack), TORSEMIDE (Camber Pharmaceuticals), TORSEMIDE (Cardinal Health), TORSEMIDE (Cardinal Health), TORSEMIDE (Cardinal Health), TORSEMIDE (Carilion Materials Management), TORSEMIDE (Carilion Materials Management), TORSEMIDE (Carilion Materials Management), TORSEMIDE (Citron Pharma LLC), TORSEMIDE (General Injectables and Vaccines), TORSEMIDE (General Injectables and Vaccines), TORSEMIDE (NCS HealthCare of KY), TORSEMIDE (NCS HealthCare of KY), TORSEMIDE (Physicians Total Care), TORSEMIDE (Pliva), TORSEMIDE (Qualitest Pharmaceuticals), TORSEMIDE (SUN PHARMACEUTICAL INDUSTRIES LIMITED), TORSEMIDE (West-Ward Pharmaceuticals Corp.)
Formula
C16H20N4O3S
Exact mass
348.1256
Mol weight
348.42
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01690  Sulfonamide diuretic
  DG01747  Furosemide type diuretic
 DG01748  Loop diuretic
  DG01747  Furosemide type diuretic
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Diuretic, Na-K-Cl cotransporter inhibitor
Comment
loop diuretic
Sulfonamide derivative
Target
SLC12A1 (NKCC2) [HSA:6557] [KO:K14425];
SLC12A2 (NKCC1) [HSA:6558] [KO:K10951]
Metabolism
Enzyme: CYP2C9 [HSA:1559], CYP2C8 [HSA:1558]
Interaction
Drug interaction
Structure map
Sulfonamide derivatives - diuretics
Ion transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C03 DIURETICS
   C03C HIGH-CEILING DIURETICS
    C03CA Sulfonamides, plain
     C03CA04 Torasemide
      D00382  Torsemide (USP)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Diuretics, Loop
   Torsemide
    D00382  Torsemide (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   213  Diuretics
    2139  Others
     D00382  Torsemide (USP); Torasemide (JAN/INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC12
    SLC12A1
     Torasemide
      D00382  Torsemide (USP)
    SLC12A2
     Torasemide
      D00382  Torsemide (USP)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP2C8
   Torasemide
    D00382  Torsemide (USP)
  CYP2C9
   Torasemide
    D00382  Torsemide (USP)
 Transporter substrates
  SLCO1B1
   Torasemide
    D00382  Torsemide (USP)
  SLCO1B3
   Torasemide
    D00382  Torsemide (USP)
BRITE hierarchy
Other DBs
CAS: 
56211-40-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        24
            1   C8y C    26.1216  -19.9949
            2   C8y C    27.3390  -19.3074
            3   S4a S    24.9155  -19.3074
            4   C8x C    26.1156  -21.3989
            5   N1b N    27.3974  -17.8975
            6   C8x C    28.5510  -20.0066
            7   N1b N    23.7036  -20.0066
            8   O3c O    25.9060  -18.3054
            9   O3c O    23.9135  -18.3054
            10  N5x N    27.3274  -22.1097
            11  C8y C    28.5393  -17.1867
            12  C8x C    28.5451  -21.4106
            13  C5a C    22.4919  -19.3132
            14  C8x C    28.5393  -15.7884
            15  C8x C    29.7453  -17.8916
            16  N1b N    21.2800  -20.0123
            17  O5a O    22.4860  -17.9149
            18  C8y C    29.7453  -15.0952
            19  C8x C    30.9571  -17.1926
            20  C1c C    20.0799  -19.3191
            21  C8x C    30.9571  -15.7943
            22  C1a C    29.7453  -13.6969
            23  C1a C    18.8681  -20.0182
            24  C1a C    20.0740  -17.9208
BOND        25
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     3   8 2
            8     3   9 2
            9     4  10 1
            10    5  11 1
            11    6  12 1
            12    7  13 1
            13   11  14 1
            14   11  15 2
            15   13  16 1
            16   13  17 2
            17   14  18 2
            18   15  19 1
            19   16  20 1
            20   18  21 1
            21   18  22 1
            22   20  23 1
            23   20  24 1
            24   10  12 2
            25   19  21 2

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