KEGG   DRUG: D00382Help
Entry
D00382                      Drug                                   

Name
Torasemide (JAN/INN);
Torsemide (USP);
Demadex (TN);
Luprac (TN)
Product
  Generic
TORSEMIDE (American Health Packaging), TORSEMIDE (American Regent), TORSEMIDE (Apotex Corp.), TORSEMIDE (Aurobindo Pharma Limited), TORSEMIDE (AvKARE), TORSEMIDE (AvPAK), TORSEMIDE (Bryant Ranch Prepack), TORSEMIDE (Bryant Ranch Prepack), TORSEMIDE (Camber Pharmaceuticals), TORSEMIDE (Cardinal Health), TORSEMIDE (Cardinal Health), TORSEMIDE (Cardinal Health), TORSEMIDE (Carilion Materials Management), TORSEMIDE (Carilion Materials Management), TORSEMIDE (General Injectables and Vaccines), TORSEMIDE (General Injectables and Vaccines), TORSEMIDE (Greenstone LLC), TORSEMIDE (NCS HealthCare of KY), TORSEMIDE (Par Pharmaceutical), TORSEMIDE (Physicians Total Care), TORSEMIDE (Pliva), TORSEMIDE (Qualitest Pharmaceuticals), TORSEMIDE (Roxane Laboratories), TORSEMIDE (SUN PHARMACEUTICAL INDUSTRIES LIMITED)
Formula
C16H20N4O3S
Exact mass
348.1256
Mol weight
348.42
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Diuretic
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
loop diuretic
Target
Na-K-Cl cotransporter 1 inhibitor [HSA:6557] [KO:K14425];
Na-K-Cl cotransporter 2 inhibitor [HSA:6558] [KO:K10951]
Metabolism
Enzyme: CYP2C9 [HSA:1559], CYP2C8 [HSA:1558]
Interaction
Drug interaction
Structure map
Sulfonamide derivatives - diuretics
Ion transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C03 DIURETICS
   C03C HIGH-CEILING DIURETICS
    C03CA Sulfonamides, plain
     C03CA04 Torasemide
      D00382  Torasemide (JAN/INN); Torsemide (USP)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Diuretics, Loop
   Torsemide
    D00382  Torasemide (JAN/INN); Torsemide (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   213  Diuretics
    2139  Others
     D00382  Torasemide (JAN/INN); Torsemide (USP)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC12
    SLC12A1
     Torasemide
      D00382  Torasemide (JAN/INN); Torsemide (USP)
    SLC12A2
     Torasemide
      D00382  Torasemide (JAN/INN); Torsemide (USP)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2C8
   Torasemide
    D00382  Torasemide (JAN/INN); Torsemide (USP)
  CYP2C9
   Torasemide
    D00382  Torasemide (JAN/INN); Torsemide (USP)
BRITE hierarchy
Other DBs
CAS: 
56211-40-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        24
            1   C8y C    26.1216  -19.9949
            2   C8y C    27.3390  -19.3074
            3   S4a S    24.9155  -19.3074
            4   C8x C    26.1156  -21.3989
            5   N1b N    27.3974  -17.8975
            6   C8x C    28.5510  -20.0066
            7   N1b N    23.7036  -20.0066
            8   O3c O    25.9060  -18.3054
            9   O3c O    23.9135  -18.3054
            10  N5x N    27.3274  -22.1097
            11  C8y C    28.5393  -17.1867
            12  C8x C    28.5451  -21.4106
            13  C5a C    22.4919  -19.3132
            14  C8x C    28.5393  -15.7884
            15  C8x C    29.7453  -17.8916
            16  N1b N    21.2800  -20.0123
            17  O5a O    22.4860  -17.9149
            18  C8y C    29.7453  -15.0952
            19  C8x C    30.9571  -17.1926
            20  C1c C    20.0799  -19.3191
            21  C8x C    30.9571  -15.7943
            22  C1a C    29.7453  -13.6969
            23  C1a C    18.8681  -20.0182
            24  C1a C    20.0740  -17.9208
BOND        25
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     3   8 2
            8     3   9 2
            9     4  10 1
            10    5  11 1
            11    6  12 1
            12    7  13 1
            13   11  14 1
            14   11  15 2
            15   13  16 1
            16   13  17 2
            17   14  18 2
            18   15  19 1
            19   16  20 1
            20   18  21 1
            21   18  22 1
            22   20  23 1
            23   20  24 1
            24   10  12 2
            25   19  21 2

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