KEGG   DRUG: D00453Help
Entry
D00453                      Drug                                   

Name
Ofloxacin (JP16/USP/INN);
OFLX;
Floxin (TN)
Product
  Generic
OFLOXACIN (Aidarex Pharmaceuticals LLC), OFLOXACIN (Akorn), OFLOXACIN OPHTHALMIC (Altaire Pharmaceuticals), OFLOXACIN OPHTHALMIC (Apotex Corp.), OFLOXACIN OTIC (Apotex Corp.), OFLOXACIN (Bausch & Lomb Incorporated), OFLOXACIN (Bausch & Lomb Incorporated), OFLOXACIN (Cadila Pharmaceuticals Limited), OFLOXACIN (Clinical Solutions Wholesale), OFLOXACIN (Clinical Solutions Wholesale), OFLOXACIN (Dr. Reddy's Laboratories Limited), OFLOXACIN (Falcon Pharmaceuticals), OFLOXACIN (Falcon Pharmaceuticals), OFLOXACIN (H.J. Harkins Company), OFLOXACIN (Hi-Tech Pharmacal), OFLOXACIN (Keltman Pharmaceuticals), OFLOXACIN (PD-Rx Pharmaceuticals), OFLOXACIN (Pack Pharmaceuticals), OFLOXACIN (PharmaForce), OFLOXACIN (Physicians Total Care), OFLOXACIN (Physicians Total Care), OFLOXACIN (Preferred Pharmaceuticals), OFLOXACIN OTIC (Preferred Pharmaceuticals), OFLOXACIN (REMEDYREPACK), OFLOXACIN (REMEDYREPACK), OFLOXACIN (REMEDYREPACK), OFLOXACIN (REMEDYREPACK), OFLOXACIN (REMEDYREPACK), OFLOXACIN (REMEDYREPACK), OFLOXACIN (REMEDYREPACK), OFLOXACIN OTIC (REMEDYREPACK), OFLOXACIN (REMEDYREPACK), OFLOXACIN (REMEDYREPACK), OFLOXACIN (REMEDYREPACK), OFLOXACIN (REMEDYREPACK), OFLOXACIN (REMEDYREPACK), OFLOXACIN (REMEDYREPACK), OFLOXACIN (Rebel Distributors Corp), OFLOXACIN (Rebel Distributors Corp), OFLOXACIN (STAT RX LLC USA), OFLOXACIN (STAT RX USA LLC), OFLOXACIN (Teva Pharmaceuticals USA), OFLOXACIN (Unit Dose Services), OFLOXACIN (Hi-Tech Pharmacal), OFLOXACIN (Preferred Pharmaceuticals), OFLOXACIN (Rebel Distributors Corp)
Formula
C18H20FN3O4
Exact mass
361.1438
Mol weight
361.3675
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibacterial
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Target
DNA gyrase inhibitor [KO:K02469 K02470];
topoisomerase IV inhibitor [KO:K02621 K02622]
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Quinolones
Other map
Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01M QUINOLONE ANTIBACTERIALS
    J01MA Fluoroquinolones
     J01MA01 Ofloxacin
      D00453  Ofloxacin (JP16/USP/INN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AE Fluoroquinolones
     S01AE01 Ofloxacin
      D00453  Ofloxacin (JP16/USP/INN)
  S02 OTOLOGICALS
   S02A ANTIINFECTIVES
    S02AA Antiinfectives
     S02AA16 Ofloxacin
      D00453  Ofloxacin (JP16/USP/INN)
USP drug classification [BR:br08302]
 Antibacterials
  Quinolones
   Ofloxacin
    D00453  Ofloxacin (JP16/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D00453  Ofloxacin (JP16/USP/INN)
   132  Otic and nasal agents
    1329  Others
     D00453  Ofloxacin (JP16/USP/INN)
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   624  Synthetic antibacterials
    6241  Pyridonecarboxylic acids
     D00453  Ofloxacin (JP16/USP/INN)
Antiinfectives [BR:br08307]
 Antibacterials
  Nucleic acid synthesis inhibitor
   type II topoisomerase (DNA gyrase, topoisomerase IV) inhibitor
    Fluoroquinolones
     Ofloxacin
      D00453  Ofloxacin (JP16/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Ofloxacin
    D00453  Ofloxacin (JP16/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00453  Ofloxacin
BRITE hierarchy
Other DBs
CAS: 
82419-36-1
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        26
            1   C8y C    23.3739  -16.5390
            2   C8y C    22.1610  -17.2388
            3   C8y C    23.3739  -15.1396
            4   N4y N    24.5867  -17.2388
            5   C8y C    20.9481  -16.5390
            6   O2x O    22.1610  -18.6382
            7   C8y C    24.5867  -14.4398
            8   C8x C    22.1610  -14.4398
            9   C8x C    25.7996  -16.5390
            10  C1y C    24.5867  -18.6382
            11  N1y N    19.7353  -17.2388
            12  C8y C    20.9481  -15.1396
            13  C1x C    23.3739  -19.3379
            14  C8y C    25.7996  -15.1396
            15  O5x O    24.5867  -13.0404
            16  C1a C    25.7996  -19.3379
            17  C1x C    18.5224  -16.5390
            18  C1x C    19.7353  -18.6382
            19  X   F    19.7353  -14.4398
            20  C6a C    27.0125  -14.4398
            21  C1x C    17.3095  -17.2388
            22  C1x C    18.5224  -19.3379
            23  O6a O    27.0125  -13.0404
            24  O6a O    28.2253  -15.1396
            25  N1y N    17.3095  -18.6382
            26  C1a C    16.0967  -19.3379
BOND        29
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 1
            9     4  10 1
            10    5  11 1
            11    5  12 1
            12    6  13 1
            13    7  14 1
            14    7  15 2
            15   10  16 1
            16   11  17 1
            17   11  18 1
            18   12  19 1
            19   14  20 1
            20   17  21 1
            21   18  22 1
            22   20  23 2
            23   20  24 1
            24   21  25 1
            25   25  26 1
            26    8  12 2
            27    9  14 2
            28   10  13 1
            29   22  25 1

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