| Entry |
|
|---|
| Name |
Ethosuximide (JP18/USP/INN);
Zarontin (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C7H11NO2
|
|---|
| Exact mass |
141.079
|
|---|
| Mol weight |
141.1677
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01575 Calcium channel blocker
DG01573 Calcium channel T type blocker
Neuropsychiatric agent
DG03199 Antiepileptic agent
DG02033 Succinimide antiepileptic
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Therapeutic category: | 1139 |
|
|---|
| Efficacy |
Antiepileptic |
|---|
| Comment |
Succinimide derivative
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N03 ANTIEPILEPTICS
N03A ANTIEPILEPTICS
N03AD Succinimide derivatives
N03AD01 Ethosuximide
D00539 Ethosuximide (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Anticonvulsants
Calcium Channel Modifying Agents
Ethosuximide
D00539 Ethosuximide (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
113 Antiepileptics
1139 Others
D00539 Ethosuximide (JP18/USP/INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01575 Calcium channel blocker
DG01573 Calcium channel T type blocker
D00539 Ethosuximide
Neuropsychiatric agent
DG03199 Antiepileptic agent
DG02033 Succinimide antiepileptic
D00539 Ethosuximide
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
D00539 Ethosuximide
Drug classes [BR:br08332]
Neuropsychiatric agent
DG03199 Antiepileptic agent
D00539 Ethosuximide
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Calcium channels
CACNA1-T
D00539 Ethosuximide (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00539 Ethosuximide
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00539
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 10
1 C1z C 30.2572 -15.7833
2 C5x C 31.0718 -14.6371
3 C1x C 28.9189 -15.3703
4 C1b C 31.5607 -16.2779
5 C1a C 29.4311 -16.9121
6 N1x N 30.2341 -13.5199
7 O5x O 32.4683 -14.6255
8 C5x C 28.9016 -13.9681
9 C1a C 31.5774 -17.6569
10 O5x O 27.7611 -13.1534
BOND 10
1 1 2 1
2 1 3 1
3 1 4 1
4 1 5 1
5 2 6 1
6 2 7 2
7 3 8 1
8 4 9 1
9 8 10 2
10 6 8 1
|
|---|
