KEGG   DRUG: Lafutidine
Entry
D01131                      Drug                                   
Name
Lafutidine (JP18/INN);
Protecadin (TN)
Formula
C22H29N3O4S
Exact mass
431.1879
Mol weight
431.5484
Structure
Class
Gastrointestinal agent
 DG01975  Agents for peptic ulcer
  DG01481  Histamine receptor H2 antagonist
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 2325
ATC code: A02BA08
Product: D01131<JP>
Efficacy
Anti-ulcerative, H2 receptor antagonist
Target
HRH2 [HSA:3274] [KO:K04150]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04971  Gastric acid secretion
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP2D6 [HSA:1565]
Interaction
Structure map
map07038  Antiulcer drugs
map07227  Histamine H2/H3 receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A02 DRUGS FOR ACID RELATED DISORDERS
   A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
    A02BA H2-receptor antagonists
     A02BA08 Lafutidine
      D01131  Lafutidine (JP18/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   232  Peptic ulcer agents
    2325  H2 blockers
     D01131  Lafutidine (JP18/INN)
Drug groups [BR:br08330]
 Gastrointestinal agent
  DG01975  Agents for peptic ulcer
   DG01481  Histamine receptor H2 antagonist
    D01131  Lafutidine
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   D01131  Lafutidine
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D01131  Lafutidine
Drug classes [BR:br08332]
 Gastrointestinal agent
  DG01481  Histamine receptor H2 antagonist
   D01131  Lafutidine
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH2
     D01131  Lafutidine (JP18/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01131  Lafutidine
  D01131  Lafutidine tablets
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01131
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01131
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01131
Other DBs
CAS: 118288-08-7
PubChem: 7848194
ChEBI: 31759
LigandBox: D01131
NIKKAJI: J485.641D
KCF data

ATOM        30
            1   C1x C    11.2700  -29.7500
            2   C1x C    11.2700  -31.1500
            3   C1x C    12.4600  -31.8500
            4   N1y N    13.7200  -31.1500
            5   C1x C    13.7200  -29.7500
            6   C1x C    12.4600  -29.0500
            7   C1b C    14.9100  -31.8500
            8   C8y C    16.1000  -31.1500
            9   C8x C    17.2900  -31.8500
            10  C8y C    18.5500  -31.1500
            11  N5x N    18.5500  -29.7500
            12  C8x C    17.3600  -29.0500
            13  C8x C    16.1000  -29.7500
            14  O2a O    19.7400  -31.8500
            15  C1b C    20.9300  -31.1500
            16  C2b C    22.1200  -31.8500
            17  C2b C    23.5200  -31.8500
            18  C1b C    24.7100  -31.1500
            19  N1b N    25.9000  -31.8500
            20  C5a C    27.0900  -31.1500
            21  C1b C    28.2800  -31.8500
            22  S4a S    29.4700  -31.1500
            23  C1b C    30.6600  -31.8500
            24  C8y C    31.8500  -31.1500
            25  O3c O    29.4700  -29.7500
            26  O5a O    27.0900  -29.7500
            27  C8x C    32.2700  -29.8200
            28  O2x O    32.9700  -31.9900
            29  C8x C    34.0900  -31.1500
            30  C8x C    33.6700  -29.8200
BOND        32
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14    8  13 1
            15   10  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 2
            19   18  19 1
            20   18  17 1
            21   19  20 1
            22   20  21 1
            23   21  22 1
            24   22  23 1
            25   23  24 1
            26   22  25 2
            27   20  26 2
            28   27  24 2
            29   24  28 1
            30   28  29 1
            31   29  30 2
            32   27  30 1

» Japanese version   » Back

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