KEGG   DRUG: Methylphenidate hydrochloride
Entry
D01296                      Drug                                   
Name
Methylphenidate hydrochloride (JAN/USP);
Concerta (TN);
Metadate (TN);
Quillivant xr (TN);
Ritalin (TN)
Product
APTENSIO XR (Rhodes Pharmaceuticals L.P.), CONCERTA (Janssen Pharmaceuticals), COTEMPLA XR-ODT (Neos Therapeutics Brands), JORNAY PM (Ironshore Pharmaceuticals), METADATE CD (Aytu BioPharma), METHYLIN (SHIONOGI), METHYLPHENIDATE HYDROCHLORIDE (Patriot Pharmaceuticals), METHYLPHENIDATE HYDROCHLORIDE (Trigen Laboratories), QUILLICHEW ER (NextWave Pharmaceuticals), QUILLIVANT (NextWave Pharmaceuticals), RELEXXII (Vertical Pharmaceuticals), RITALIN (Novartis Pharmaceuticals Corporation), RITALIN (Novartis Pharmaceuticals Corporation)
  Generic
METHYLPHENIDATE (KVK-Tech), METHYLPHENIDATE (Sandoz), METHYLPHENIDATE HCL (Patrin Pharma), METHYLPHENIDATE HYDROCHLORIDE (Accord Healthcare), METHYLPHENIDATE HYDROCHLORIDE (Actavis Pharma), METHYLPHENIDATE HYDROCHLORIDE (Actavis Pharma), METHYLPHENIDATE HYDROCHLORIDE (American Health Packaging), METHYLPHENIDATE HYDROCHLORIDE (American Health Packaging), METHYLPHENIDATE HYDROCHLORIDE (Amneal Pharmaceuticals LLC), METHYLPHENIDATE HYDROCHLORIDE (Amneal Pharmaceuticals of New York LLC), METHYLPHENIDATE HYDROCHLORIDE (Amneal Pharmaceuticals of New York LLC), METHYLPHENIDATE HYDROCHLORIDE (Ascend Laboratories), METHYLPHENIDATE HYDROCHLORIDE (Ascend Laboratories), METHYLPHENIDATE HYDROCHLORIDE (Ascend Laboratories), METHYLPHENIDATE HYDROCHLORIDE (Ascent Pharmaceuticals), METHYLPHENIDATE HYDROCHLORIDE (AvKARE), METHYLPHENIDATE HYDROCHLORIDE (AvPAK), METHYLPHENIDATE HYDROCHLORIDE (AvPAK), METHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), METHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), METHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), METHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), METHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), METHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), METHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), METHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), METHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), METHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), METHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), METHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), METHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), METHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), METHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), METHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), METHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), METHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), METHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), METHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), METHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), METHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), METHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), METHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), METHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), METHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), METHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), METHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), METHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), METHYLPHENIDATE HYDROCHLORIDE (Bryant Ranch Prepack), METHYLPHENIDATE HYDROCHLORIDE (Camber Pharmaceutical), METHYLPHENIDATE HYDROCHLORIDE (Camber Pharmaceuticals), METHYLPHENIDATE HYDROCHLORIDE (Camber Pharmaceuticals), METHYLPHENIDATE HYDROCHLORIDE (Dr.Reddys Laboratories), METHYLPHENIDATE HYDROCHLORIDE (Eywa Pharma), METHYLPHENIDATE HYDROCHLORIDE (Golden State Medical Supply), METHYLPHENIDATE HYDROCHLORIDE (Granules Pharmaceuticals), METHYLPHENIDATE HYDROCHLORIDE (Granules Pharmaceuticals), METHYLPHENIDATE HYDROCHLORIDE (KVK-TECH), METHYLPHENIDATE HYDROCHLORIDE (LA) (Mayne Pharma), METHYLPHENIDATE HYDROCHLORIDE (Lannett Company), METHYLPHENIDATE HYDROCHLORIDE (Lupin Pharmaceuticals), METHYLPHENIDATE HYDROCHLORIDE (Lupin Pharmaceuticals), METHYLPHENIDATE HYDROCHLORIDE (Lupin Pharmaceuticals), METHYLPHENIDATE HYDROCHLORIDE (Neolpharma), METHYLPHENIDATE HYDROCHLORIDE (Northstar Rx LLC), METHYLPHENIDATE HYDROCHLORIDE (Novel Laboratories), METHYLPHENIDATE HYDROCHLORIDE (QUAGEN PHARMACEUTICALS LLC), METHYLPHENIDATE HYDROCHLORIDE (Rhodes Pharmaceuticals), METHYLPHENIDATE HYDROCHLORIDE (Rising Pharma Holdings), METHYLPHENIDATE HYDROCHLORIDE (Solco Healthcare US), METHYLPHENIDATE HYDROCHLORIDE (SpecGx LLC), METHYLPHENIDATE HYDROCHLORIDE (SpecGx LLC), METHYLPHENIDATE HYDROCHLORIDE (SpecGx LLC), METHYLPHENIDATE HYDROCHLORIDE (Sun Pharmaceutical Industries), METHYLPHENIDATE HYDROCHLORIDE (Sun Pharmaceutical Industries), METHYLPHENIDATE HYDROCHLORIDE (Teva Pharmaceuticals USA), METHYLPHENIDATE HYDROCHLORIDE (Teva Pharmaceuticals USA), METHYLPHENIDATE HYDROCHLORIDE (Trigen Laboratories), METHYLPHENIDATE HYDROCHLORIDE (Tris Pharma), METHYLPHENIDATE HYDROCHLORIDE (XLCare Pharmaceuticals), METHYLPHENIDATE HYDROCHLORIDE (XLCare Pharmaceuticals), METHYLPHENIDATE HYDROCHLORIDE (XLCare Pharmaceuticals), METHYLPHENIDATE HYDROCHLORIDE CD (Lannett Company), METHYLPHENIDATE HYDROCHLORIDE EXTENDED RELEASE (KVK-Tech)
Formula
C14H19NO2. HCl
Exact mass
269.1183
Mol weight
269.7671
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01971  Agents for narcolepsy
Remark
Therapeutic category: 1179
ATC code: N06BA04
Chemical structure group: DG00969
Product (DG00969): D04999<US> D01296<JP/US>
Efficacy
Stimulant (central)
  Disease
Attention deficit hyperactivity disorder [DS:H01895]
Narcolepsy [DS:H01293]
Comment
piperidine derivative
Target
SLC6A3 (DAT1) [HSA:6531] [KO:K05036]
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
  Pathway
hsa04721  Synaptic vesicle cycle
hsa04728  Dopaminergic synapse
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06B PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
    N06BA Centrally acting sympathomimetics
     N06BA04 Methylphenidate
      D01296  Methylphenidate hydrochloride (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Central Nervous System Agents
  Attention Deficit Hyperactivity Disorder Agents, Non-amphetamines
   Methylphenidate
    D01296  Methylphenidate hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D01296  Methylphenidate hydrochloride (JAN/USP)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01971  Agents for narcolepsy
   D01296  Methylphenidate hydrochloride
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D01296  Methylphenidate hydrochloride (JAN/USP) <JP/US>
    SLC6A3 (DAT1)
     D01296  Methylphenidate hydrochloride (JAN/USP) <JP/US>
Other DBs
CAS: 298-59-9
PubChem: 7848359
ChEBI: 31836
LigandBox: D01296
NIKKAJI: J252.851G
KCF data

ATOM        18
            1   C1c C    24.3131  -18.3693
            2   C8y C    24.3014  -19.7673
            3   C1y C    23.1133  -17.6530
            4   C7a C    25.5364  -17.6763
            5   C8x C    23.0840  -20.4546
            6   C8x C    25.5072  -20.4779
            7   C1x C    21.8959  -18.3403
            8   N1x N    23.1307  -16.2550
            9   O7a O    25.5538  -16.2783
            10  O6a O    26.7421  -18.3926
            11  C8x C    23.0724  -21.8583
            12  C8x C    25.4898  -21.8759
            13  C1x C    20.6902  -17.6296
            14  C1x C    21.9249  -15.5385
            15  C1a C    26.7712  -15.5910
            16  C8x C    24.2665  -22.5689
            17  C1x C    20.7018  -16.2258
            18  X   Cl   30.7573  -18.5477
BOND        18
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 1
            9     4  10 2
            10    5  11 1
            11    6  12 2
            12    7  13 1
            13    8  14 1
            14    9  15 1
            15   11  16 2
            16   13  17 1
            17   12  16 1
            18   14  17 1

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Ontology (5)   
   KEGG BRITE (5)   
Disease (2)   
   KEGG DISEASE (2)   
Drug (4)   
   KEGG DGROUP (2)   
   LigandBox (1)   
   SIDER (1)   
Chemical substance (3)   
   PubChem (1)   
   ChEBI (1)   
   NIKKAJI (1)   
Gene (4)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (2)   
All databases (18)   

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