| Entry |
|
|---|
| Name |
Colistimethate sodium (USP);
Colistin sodium methanesulfonate (JP18);
Coly-Mycin M (TN);
Methacolimycin (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C49H88N16O27S5R. 5Na
|
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| Structure |
|
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| Simcomp |
|
|---|
| Class |
Antibacterial
DG01579 Polypeptide antibiotic
|
|---|
| Remark |
| Therapeutic category: | 6125 |
| Product (DG00087): | D02049<JP/US> |
| Product (mixture): | D04099<JP> D04106<JP> |
|
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| Efficacy |
Antibacterial, Cell membrane function inhibitor |
|---|
| Comment |
Colistin A component (R = 6-methyloctanoic acid)
Colistin B component (R = 6-methylheptanoic acid)
Polypeptide
|
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| Target |
Lipopolysaccharide |
|---|
| Interaction |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
A07A INTESTINAL ANTIINFECTIVES
A07AA Antibiotics
A07AA10 Colistin
D02049 Colistimethate sodium (USP) <JP/US>
J ANTIINFECTIVES FOR SYSTEMIC USE
J01 ANTIBACTERIALS FOR SYSTEMIC USE
J01X OTHER ANTIBACTERIALS
J01XB Polymyxins
J01XB01 Colistin
D02049 Colistimethate sodium (USP) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
6 Agents against pathologic organisms and parasites
61 Antibiotics
612 Acting mainly on gram-negative bacteria
6125 Colistins
D02049 Colistimethate sodium (USP); Colistin sodium methanesulfonate (JP18)
Drug groups [BR:br08330]
Antibacterial
DG01579 Polypeptide antibiotic
DG00087 Colistin
D02049 Colistimethate sodium
Antimicrobials [BR:br08307]
Antibacterials
Cell membrane function inhibitor
Polypeptide
D02049 Colistimethate sodium (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D02049 Colistin sodium methanesulfonate
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D02049
Drug groups [BR:br08330]
Antibacterial
DG01579 Polypeptide antibiotic
DG00087 Colistin
Antimicrobials abbreviations [BR:br08327]
Antibacterials
Cell membrane function inhibitor
Polypeptide
DG00087 Colistin
|
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| Other DBs |
|
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| KCF data |
ATOM 103
1 C1c C 24.8009 -11.9720
2 N1b N 24.8009 -13.3639
3 N1b N 27.2134 -11.9720
4 C5a C 26.0071 -11.2761
5 C5a C 29.6257 -11.9720
6 C1c C 28.4195 -11.2761
7 C1c C 32.0383 -11.9720
8 N1b N 30.8320 -11.2761
9 C5a C 23.5947 -14.0596
10 C1c C 23.5947 -15.4514
11 C1b C 24.8009 -16.1472
12 C1b C 24.8009 -17.5391
13 N1b N 26.0071 -18.2350
14 C5a C 27.2134 -17.5391
15 C1c C 28.4195 -18.2350
16 N1b N 29.6257 -17.5391
17 C5a C 30.8320 -18.2350
18 C1c C 32.0383 -17.5391
19 O5a O 26.0071 -9.8843
20 C1c C 34.4508 -11.9720
21 C1b C 33.2445 -11.2761
22 C1b C 28.4195 -9.4667
23 C5a C 32.0383 -13.3639
24 C1a C 35.6569 -11.2761
25 C1a C 34.4508 -13.3639
26 O5a O 30.8320 -14.0596
27 C1c C 29.6257 -8.7708
28 C1a C 30.8784 -9.4667
29 C1a C 29.6257 -7.3326
30 O5a O 29.6257 -13.3639
31 C1b C 23.5947 -11.2761
32 O5a O 22.3884 -13.3639
33 N1b N 22.3884 -16.1472
34 O5a O 27.2134 -16.1472
35 C1c C 28.4195 -19.7661
36 O1a O 29.6257 -20.4620
37 C1a C 27.2134 -20.4620
38 O5a O 30.8320 -19.6268
39 N1b N 32.0383 -16.1472
40 C5a C 33.4300 -16.1472
41 N1b N 33.2445 -14.0596
42 C1c C 34.1260 -14.9875
43 C1b C 35.5178 -14.9875
44 C1b C 33.2435 -18.2352
45 C1b C 33.2450 -19.6268
46 N1b N 34.4506 -20.3223
47 C1b C 23.5942 -9.8845
48 N1b N 22.3888 -9.1920
49 C5a C 21.1839 -15.4523
50 C1c C 19.9785 -16.1481
51 N1b N 18.7732 -15.4523
52 C5a C 17.5676 -16.1481
53 C1c C 16.3622 -15.4523
54 N1b N 15.1568 -16.1481
55 C5a C 13.9513 -15.4523
56 C1c C 12.7459 -16.1481
57 N1b N 11.5406 -15.4523
58 O5a O 21.1837 -14.0604
59 C1b C 19.9785 -17.5401
60 O5a O 17.5676 -17.5401
61 C1c C 16.3622 -13.7821
62 C1a C 15.1535 -13.0842
63 O1a O 17.5644 -13.0881
64 O5a O 13.9513 -14.0604
65 C1b C 12.7459 -17.5401
66 C1b C 18.7695 -18.2329
67 N1b N 18.7658 -19.6248
68 C1b C 17.5586 -20.3175
69 C1b C 11.5353 -18.2392
70 N1b N 11.5326 -19.6282
71 C1b C 10.3334 -20.3345
72 O5a O 34.1171 -17.3605
73 R R 10.3293 -16.1517
74 C1b C 21.2054 -9.8791
75 S4a S 20.0206 -9.1988
76 O1d O 18.8150 -8.5028 #-
77 O1d O 19.3372 -10.3863
78 O1d O 20.7257 -7.9735
79 S4a S 9.0964 -19.6333
80 O1d O 7.8909 -18.9373 #-
81 O1d O 8.4130 -20.8284
82 O1d O 9.7949 -18.4119
83 S4a S 16.3466 -19.6134
84 O1d O 15.1411 -18.9174 #-
85 O1d O 17.0404 -18.4156
86 O1d O 15.6451 -20.8245
87 C1b C 36.2002 -16.1692
88 N1b N 37.5875 -16.1691
89 C1b C 38.2754 -17.3599
90 S4a S 39.6754 -17.3598
91 O1d O 41.0674 -17.3598
92 O1d O 39.6754 -15.9409 #-
93 O1d O 39.6755 -18.7250
94 C1b C 35.6593 -19.6238
95 S4a S 36.8818 -20.3294
96 O1d O 38.0940 -21.0292 #-
97 O1d O 37.5965 -19.0921
98 O1d O 36.1965 -21.5158
99 Z Na 7.7624 -17.8711 #+
100 Z Na 13.2467 -18.8055 #+
101 Z Na 39.5438 -21.0678 #+
102 Z Na 39.4418 -14.7867 #+
103 Z Na 16.8465 -8.4240 #+
BOND 98
1 1 2 1
2 3 4 1
3 1 4 1
4 5 6 1
5 3 6 1
6 7 8 1
7 5 8 1
8 2 9 1
9 9 10 1
10 10 11 1
11 11 12 1
12 12 13 1
13 13 14 1
14 14 15 1
15 15 16 1
16 16 17 1
17 17 18 1
18 4 19 2
19 20 21 1
20 7 21 1
21 6 22 1
22 7 23 1
23 20 24 1
24 20 25 1
25 23 26 2
26 22 27 1
27 27 28 1
28 27 29 1
29 5 30 2
30 1 31 1
31 9 32 2
32 10 33 1
33 14 34 2
34 15 35 1
35 35 36 1
36 35 37 1
37 17 38 2
38 18 39 1
39 39 40 1
40 23 41 1
41 40 42 1
42 41 42 1
43 42 43 1
44 18 44 1
45 44 45 1
46 45 46 1
47 31 47 1
48 47 48 1
49 33 49 1
50 49 50 1
51 50 51 1
52 51 52 1
53 52 53 1
54 53 54 1
55 54 55 1
56 55 56 1
57 56 57 1
58 49 58 2
59 50 59 1
60 52 60 2
61 53 61 1
62 61 62 1
63 61 63 1
64 55 64 2
65 56 65 1
66 59 66 1
67 66 67 1
68 67 68 1
69 65 69 1
70 69 70 1
71 70 71 1
72 40 72 2
73 57 73 1
74 48 74 1
75 74 75 1
76 75 76 1
77 75 77 2
78 75 78 2
79 71 79 1
80 79 80 1
81 79 81 2
82 79 82 2
83 68 83 1
84 83 84 1
85 83 85 2
86 83 86 2
87 43 87 1
88 87 88 1
89 88 89 1
90 89 90 1
91 90 91 2
92 90 92 1
93 90 93 2
94 46 94 1
95 94 95 1
96 95 96 1
97 95 97 2
98 95 98 2
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