| Entry |
|
|---|
| Name |
Paroxetine (USP/INN);
Paroxetine (TN)
|
|---|
| Formula |
C19H20FNO3
|
|---|
| Exact mass |
329.1427
|
|---|
| Mol weight |
329.3654
|
|---|
| Structure |
     |
|---|
| Activity |
Antidepressant
|
|---|
| Remark |
|
|---|
| Comment |
Selective serotonin reuptake inhibitor (SSRI)
|
|---|
| Target |
serotonin transporter inhibitor [HSA: 6532] [KO: K05037] |
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
Transporter: ABCB1 [HSA: 5243]
|
|---|
| Interaction |
Genomic biomarker: CYP2D6 [HSA: 1565]
CYP inhibition: CYP2D6 [HSA: 1565]
 |
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| Structure map |
| Antidepressants | | Neurotransmitter transporter inhibitors |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06A ANTIDEPRESSANTS
N06AB Selective serotonin reuptake inhibitors
N06AB05 Paroxetine
D02362 Paroxetine (USP/INN)
USP drug classification [BR:br08302]
Antidepressants
Serotonin / Norepinephrine Reuptake Inhibitors
Paroxetine
D02362 Paroxetine (USP/INN)
Anxiolytics
SSRIs / SNRIs (Selective Serotonin Reuptake Inhibitors / Serotonin and Norepinephrine Reuptake Inhibitors)
Paroxetine
D02362 Paroxetine (USP/INN)
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC6
SLC6A4 (serotonin transporter) [HSA:6532] [KO:K05037]
Paroxetine [ATC:N06AB05]
D02362 Paroxetine (USP/INN)
 |
|---|
| Other DBs |
CAS: 61869-08-7 PubChem: DrugBank: PDB-CCD: LigandBox: NIKKAJI: |
|---|
| KCF data |
ATOM 24
1 C1y C 24.7626 -18.6745
2 C1y C 23.5491 -19.3721
3 C8y C 24.7684 -17.3611
4 C1x C 25.9759 -19.3721
5 C1b C 22.3356 -18.6745
6 C1x C 23.5491 -20.7791
7 C8x C 25.9819 -16.6634
8 C8x C 23.5549 -16.6634
9 C1x C 25.9759 -20.7791
10 O2a O 21.1161 -19.3721
11 N1x N 24.7626 -21.4766
12 C8x C 25.9819 -15.2624
13 C8x C 23.5549 -15.2566
14 C8y C 19.9026 -18.6686
15 C8y C 24.7684 -14.5589
16 C8x C 19.9086 -17.2733
17 C8x C 18.6951 -19.3781
18 X F 24.7743 -13.2982
19 C8y C 18.7008 -16.5699
20 C8x C 17.4816 -18.6745
21 C8y C 17.4816 -17.2733
22 O2x O 18.4137 -15.1456
23 O2x O 16.4848 -16.2829
24 C1x C 16.9657 -14.8996
BOND 27
1 1 2 1
2 1 3 1 #Down
3 1 4 1
4 2 5 1 #Up
5 2 6 1
6 3 7 2
7 3 8 1
8 4 9 1
9 5 10 1
10 6 11 1
11 7 12 1
12 8 13 2
13 10 14 1
14 12 15 2
15 14 16 2
16 14 17 1
17 15 18 1
18 16 19 1
19 17 20 2
20 19 21 2
21 19 22 1
22 21 23 1
23 22 24 1
24 9 11 1
25 13 15 1
26 20 21 1
27 23 24 1
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