KEGG   DRUG: Imiquimod
Entry
D02500                      Drug                                   
Name
Imiquimod (JAN/USP/INN);
Aldara (TN);
Zyclara (TN)
  Abbr
IQM
Product
ALDARA (Bausch Health US LLC), IMIQUIMOD (Oceanside Pharmacueticals), ZYCLARA (Bausch Health US)
  Generic
IMIQUIMOD (Bryant Ranch Prepack), IMIQUIMOD (DIRECT RX), IMIQUIMOD (E. Fougera & Co. a division of Fougera Pharmaceuticals), IMIQUIMOD (Glenmark Pharmaceuticals), IMIQUIMOD (Padagis Israel Pharmaceuticals), IMIQUIMOD (Taro Pharmaceuticals U.S.A.), IMIQUIMOD (Taro Pharmaceuticals U.S.A.), IMIQUIMOD (Teva Pharmaceuticals USA)
Formula
C14H16N4
Exact mass
240.1375
Mol weight
240.3036
Structure
Simcomp
Remark
Therapeutic category: 6290
ATC code: D06BB10
Product: D02500<JP/US>
Efficacy
Antiviral, Immunomodulator, Toll-like receptor agonist
  Disease
Actinic keratosis [DS:H02429]
Basal cell carcinoma [DS:H00029]
Genital warts [DS:H01418]
Target
TLR7 [HSA:51284] [KO:K05404]
  Pathway
hsa04613  Neutrophil extracellular trap formation
hsa04620  Toll-like receptor signaling pathway
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D06 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
   D06B CHEMOTHERAPEUTICS FOR TOPICAL USE
    D06BB Antivirals
     D06BB10 Imiquimod
      D02500  Imiquimod (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Dermatological Agents
  Dermatological Agents, Other
   Warts and Actinic Keratosis Agents
    Imiquimod
     D02500  Imiquimod (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   629  Miscellaneous
    6290  Miscellaneous
     D02500  Imiquimod (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Pattern recognition receptors
   Toll-like receptors
    TLR7
     D02500  Imiquimod (JAN/USP/INN) <JP/US>
Antimicrobials [BR:br08307]
 Antivirals
  Genome replication inhibitor
   Other inhibitor
    D02500  Imiquimod (JAN/USP/INN) <JP/US>
Antimicrobials abbreviations [BR:br08327]
 Antivirals
  Genome replication inhibitor
   Other inhibitor
    D02500  Imiquimod (JAN/USP/INN)
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D02500
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D02500
Other DBs
CAS: 99011-02-6
PubChem: 17396674
PDB-CCD: 6T0[PDBj]
LigandBox: D02500
NIKKAJI: J501.447F
KCF data

ATOM        18
            1   C8y C    24.0293  -16.9272
            2   C8y C    24.0236  -15.5377
            3   N4y N    22.7098  -17.3632
            4   C8y C    25.2386  -17.6247
            5   N5x N    22.7039  -15.1133
            6   C8y C    25.2386  -14.8400
            7   C8x C    21.8842  -16.2353
            8   C1b C    22.6922  -18.9793
            9   C8y C    26.4361  -16.9272
            10  N5x N    26.4361  -15.5377
            11  N1a N    25.2386  -13.4506
            12  C1c C    21.5761  -19.6886
            13  C1a C    20.4482  -18.9851
            14  C1a C    21.5819  -21.0799
            15  C8x C    25.2422  -18.9858
            16  C8x C    27.6759  -17.6394
            17  C8x C    27.6796  -19.0554
            18  C8x C    26.4964  -19.7428
BOND        20
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     3   8 1
            8     4   9 1
            9     6  10 1
            10    6  11 1
            11    8  12 1
            12   12  13 1
            13    5   7 2
            14    9  10 2
            15   12  14 1
            16    4  15 1
            17    9  16 1
            18   16  17 2
            19   17  18 1
            20   18  15 2

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Ontology (8)   
   KEGG BRITE (8)   
Disease (3)   
   KEGG DISEASE (3)   
Drug (2)   
   LigandBox (1)   
   SIDER (1)   
Chemical substance (4)   
   PubChem (1)   
   HMDB (1)   
   NIKKAJI (1)   
   PDB-CCD (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
All databases (19)   

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