KEGG   DRUG: Rasagiline mesylate
Entry
D02562                      Drug                                   
Name
Rasagiline mesylate (USAN);
Rasagiline mesilate (JAN);
Azilect (TN)
Product
  Generic
Formula
C12H13N. CH4SO3
Exact mass
267.0929
Mol weight
267.344
Structure
Class
Neuropsychiatric agent
 DG01568  MAO inhibitor
  DG01512  Monoamine oxidase B inhibitor
 DG01967  Antiparkinson agent
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
Remark
Therapeutic category: 1169
ATC code: N04BD02
Chemical structure group: DG00865
Product (DG00865): D02562<JP/US>
Efficacy
Antiparkinsonian, Monoamine oxidase B (MAO-B) inhibitor
  Disease
Parkinson's disease [DS:H00057]
Target
MAOB [HSA:4129] [KO:K00274]
  Pathway
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP1A2 [HSA:1544]
Interaction
Structure map
map07027  Antidepressants
map07057  Antiparkinsonian agents
map07216  Catecholamine transferase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N04 ANTI-PARKINSON DRUGS
   N04B DOPAMINERGIC AGENTS
    N04BD Monoamine oxidase B inhibitors
     N04BD02 Rasagiline
      D02562  Rasagiline mesylate (USAN) <JP/US>
USP drug classification [BR:br08302]
 Antiparkinson Agents
  Monoamine Oxidase B (MAO-B) Inhibitors
   Rasagiline
    D02562  Rasagiline mesylate (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   116  Antiparkinsonian agents
    1169  Others
     D02562  Rasagiline mesylate (USAN); Rasagiline mesilate (JAN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01568  MAO inhibitor
   DG01512  Monoamine oxidase B inhibitor
    DG00865  Rasagiline
     D02562  Rasagiline mesylate
  DG01967  Antiparkinson agent
   DG00865  Rasagiline
    D02562  Rasagiline mesylate
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00865  Rasagiline
    D02562  Rasagiline mesylate
Drug classes [BR:br08332]
 Neuropsychiatric agent
  DG01967  Antiparkinson agent
   D02562  Rasagiline mesylate
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Amine oxidases
    MAOB
     D02562  Rasagiline mesylate (USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D02562
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D02562
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D02562
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D02562
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02562
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01568  MAO inhibitor
   DG01512  Monoamine oxidase B inhibitor
    DG00865  Rasagiline
  DG01967  Antiparkinson agent
   DG00865  Rasagiline
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00865  Rasagiline
Other DBs
CAS: 161735-79-1
PubChem: 17396733
LigandBox: D02562
KCF data

ATOM        18
            1   C8y C    19.8358  -20.6271
            2   C8y C    19.8358  -19.2233
            3   C8x C    18.6201  -18.5214
            4   C8x C    17.4042  -19.2233
            5   C8x C    17.4042  -20.6271
            6   C8x C    18.6201  -21.3291
            7   C1y C    21.1709  -21.0609
            8   C1x C    21.9961  -19.9252
            9   C1x C    21.1709  -18.7895
            10  N1b N    21.1694  -22.4521
            11  C1b C    22.3845  -23.1554
            12  C3b C    23.5851  -22.4638
            13  C3a C    24.7493  -21.7502
            14  O1d O    30.5752  -19.7146
            15  S4a S    30.5752  -21.1185
            16  C1a C    29.1714  -21.1185
            17  O1d O    31.9791  -21.1185
            18  O1d O    30.5752  -22.5223
BOND        18
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     8   9 1
            10    2   9 1
            11    7  10 1 #Up
            12   10  11 1
            13   11  12 1
            14   12  13 3
            15   14  15 2
            16   15  16 1
            17   15  17 1
            18   15  18 2

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