KEGG DRUG: Atomoxetine hydrochloride

DRUG: Atomoxetine hydrochloride

Entry

D02574                      Drug

Name

Atomoxetine hydrochloride (JAN/USP);
Tomoxetine hydrochloride;
Strattera (TN)

Product

STRATTERA (Eli Lilly and Company)

Generic

Formula

C17H21NO. HCl

Exact mass

291.139

Mol weight

291.8157

Structure

Simcomp

Class

Neuropsychiatric agent
DG03085 Selective norepinephrine reuptake inhibitor (NRI)
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate

Remark

Therapeutic category:

1179

ATC code:

N06BA09

Chemical structure group:

DG00970

Product (DG00970):

D02574<JP/US>

Efficacy

Stimulant (central), Selective noradrenaline reuptake inhibitor (NRI)

Disease

Attention-deficit/hyperactivity disorder [DS:H01895]

Comment

Fluoxetine derivative
Treatment of attention deficit hyperactivity disorder (ADHD)

Target

SLC6A2 (NAT1) [HSA:6530] [KO:K05035]

Pathway

hsa04721

Synaptic vesicle cycle

Metabolism

Enzyme: CYP2D6 [HSA:1565]

Interaction

Structure map

map07234

Neurotransmitter transporter inhibitors

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06B PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
    N06BA Centrally acting sympathomimetics
     N06BA09 Atomoxetine
      D02574  Atomoxetine hydrochloride (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
Central Nervous System Agents
  Attention Deficit Hyperactivity Disorder Agents, Non-amphetamines
   Atomoxetine
    D02574  Atomoxetine hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D02574  Atomoxetine hydrochloride (JAN/USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG03085  Selective norepinephrine reuptake inhibitor (NRI)
   DG00970  Atomoxetine
    D02574  Atomoxetine hydrochloride
Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00970  Atomoxetine
    D02574  Atomoxetine hydrochloride
Target-based classification of drugs [BR:br08310]
Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D02574  Atomoxetine hydrochloride (JAN/USP) <JP/US>
New drug approvals in the USA [br08319.html]
New molecular entities and new therapeutic biological products
  D02574
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
  D02574
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
  D02574
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
  D02574
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
  D02574
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG03085  Selective norepinephrine reuptake inhibitor (NRI)
   DG00970  Atomoxetine
Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00970  Atomoxetine

Other DBs

CAS:	82248-59-7

PubChem:

ChEBI:

LigandBox:

NIKKAJI:

KCF data

ATOM        20
            1   C8x C    11.5500  -14.3500
            2   C8x C    11.5500  -15.7500
            3   C8x C    12.7624  -16.4500
            4   C8x C    13.9749  -15.7500
            5   C8y C    13.9749  -14.3500
            6   C8y C    12.7624  -13.6500
            7   C1a C    12.7624  -12.2502
            8   O2a O    15.2124  -13.6500
            9   C1c C    16.4249  -14.3500
            10  C1b C    17.6373  -13.6500
            11  C1b C    18.8497  -14.3500
            12  N1b N    20.0622  -13.6500
            13  C1a C    21.2746  -14.3500
            14  C8y C    16.4249  -15.7498
            15  C8x C    15.2313  -16.4391
            16  C8x C    15.2315  -17.8391
            17  C8x C    16.4441  -18.5389
            18  C8x C    17.6376  -17.8496
            19  C8x C    17.6374  -16.4496
            20  X   Cl   26.6700  -14.4200
BOND        20
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     6   7 1
            8     5   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14    9  14 1 #Down
            15   14  15 2
            16   15  16 1
            17   16  17 2
            18   17  18 1
            19   18  19 2
            20   14  19 1

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Ontology (10)   
   KEGG BRITE (10)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (3)   
   KEGG DGROUP (1)   
   LigandBox (1)   
   SIDER (1)   
Chemical substance (3)   
   PubChem (1)   
   ChEBI (1)   
   NIKKAJI (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
All databases (20)   

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