KEGG   DRUG: Pertuzumab
Entry
D05446                      Drug                                   
Name
Pertuzumab (USAN/INN);
Pertuzumab (genetical recombination) (JAN);
Perjeta (TN)
Product
PERJETA (Genentech)
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
   DG03158  HER2 inhibitor
Remark
Therapeutic category: 4291
ATC code: L01FD02
Product: D05446<JP/US>
Product (mixture): D11934<JP/US>
Efficacy
Antineoplastic, Receptor tyrosine kinase inhibitor, Anti-HER2 antibody
  Disease
Breast cancer (HER2 positive) [DS:H00031]
  Type
Monoclonal antibody
Target
ERBB2* (HER2, CD340) [HSA_VAR:2064v1 2064v3] [HSA:2064] [KO:K05083]
  Pathway
hsa04012  ErbB signaling pathway
hsa05200  Pathways in cancer
hsa05224  Breast cancer
  Network
nt06270  Breast cancer
Interaction
Structure map
map07045  Antineoplastics - protein kinase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01F MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES
    L01FD HER2 (Human Epidermal Growth Factor Receptor 2) inhibitors
     L01FD02 Pertuzumab
      D05446  Pertuzumab (USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Monoclonal Antibody/Antibody-Drug Conjugate
   Pertuzumab
    D05446  Pertuzumab (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D05446  Pertuzumab (USAN/INN); Pertuzumab (genetical recombination) (JAN)
Drug groups [BR:br08330]
 Antineoplastic
  DG01918  Tyrosine kinase inhibitor
   DG01917  Receptor tyrosine kinase inhibitor
    DG03158  HER2 inhibitor
     D05446  Pertuzumab
Drug classes [BR:br08332]
 Antineoplastic
  DG03158  HER2 inhibitor
   D05446  Pertuzumab
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   EGFR family
    ERBB2* (HER2, CD340) [HSA_VAR:2064v1 2064v3]
     D05446  Pertuzumab (USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D05446
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D05446
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D05446
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D05446
Pharmacogenomic biomarkers [br08341.html]
 Somatic variations in targeted cancer therapies
  D05446
Other DBs
CAS: 380610-27-5
PubChem: 47207115

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Ontology (11)   
   KEGG BRITE (11)   
Pathway (1)   
   KEGG PATHWAY (1)   
Network (2)   
   KEGG VARIANT (2)   
Disease (2)   
   KEGG DISEASE (2)   
Drug (1)   
   KEGG DGROUP (1)   
Chemical substance (1)   
   PubChem (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
All databases (20)   

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