| Entry |
|
|---|
| Name |
Solifenacin (INN) |
|---|
| Formula |
C23H26N2O2
|
|---|
| Exact mass |
362.1994
|
|---|
| Mol weight |
362.4647
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01491 Muscarinic cholinergic receptor antagonist
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Product (DG00481): | D01269<JP/US> |
|
|---|
| Efficacy |
Overactive bladder agent, Muscarinic acetylcholine receptor antagonist |
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
G GENITO URINARY SYSTEM AND SEX HORMONES
G04 UROLOGICALS
G04B UROLOGICALS
G04BD Drugs for urinary frequency and incontinence
G04BD08 Solifenacin
D08522 Solifenacin (INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01491 Muscarinic cholinergic receptor antagonist
DG00481 Solifenacin
D08522 Solifenacin
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00481 Solifenacin
D08522 Solifenacin
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Acetylcholine (muscarinic)
CHRM3
D08522 Solifenacin (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08522
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01491 Muscarinic cholinergic receptor antagonist
DG00481 Solifenacin
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00481 Solifenacin
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 27
1 C1y C 22.5322 -14.8066
2 C1x C 22.5322 -13.4035
3 C1y C 21.3396 -15.5082
4 C1x C 23.7950 -15.5082
5 C1x C 23.2338 -14.5961
6 C1x C 22.0411 -16.7008
7 C1x C 24.4264 -16.7008
8 N1y N 23.2338 -15.9992
9 C1x C 16.4989 -12.7020
10 C1x C 17.6915 -13.4035
11 N1y N 17.6915 -14.8066
12 C1y C 16.4989 -15.5082
13 C8y C 15.2361 -13.4035
14 C8y C 15.2361 -14.8066
15 C8x C 14.0434 -15.5082
16 C8x C 12.8508 -14.8066
17 C8x C 12.8508 -13.4035
18 C8x C 14.0434 -12.7020
19 C8y C 16.4989 -16.9113
20 C8x C 17.6915 -17.6128
21 C8x C 17.6915 -19.0159
22 C8x C 16.4989 -19.7175
23 C8x C 15.2361 -19.0159
24 C8x C 15.2361 -17.6128
25 C7a C 18.8841 -15.5082
26 O7a O 20.1469 -14.8066
27 O6a O 18.8841 -16.9113
BOND 31
1 13 9 1
2 9 10 1
3 10 11 1
4 11 12 1
5 12 14 1
6 1 2 1
7 13 14 2
8 14 15 1
9 15 16 2
10 16 17 1
11 17 18 2
12 18 13 1
13 1 3 1
14 12 19 1 #Up
15 1 4 1
16 2 5 1
17 3 6 1
18 4 7 1
19 5 8 1
20 19 20 2
21 20 21 1
22 21 22 2
23 22 23 1
24 23 24 2
25 24 19 1
26 6 8 1
27 11 25 1
28 7 8 1
29 25 26 1
30 25 27 2
31 3 26 1 #Down
|
|---|
