KEGG   DRUG: Viloxazine
Entry
D08673                      Drug                                   
Name
Viloxazine (INN)
Formula
C13H19NO3
Exact mass
237.1365
Mol weight
237.2949
Structure
Simcomp
Class
Neuropsychiatric agent
 DG03085  Selective norepinephrine reuptake inhibitor (NRI)
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
 DG02924  UGT substrate
  DG03188  UGT1A9 substrate
  DG03187  UGT2B15 substrate
Remark
ATC code: N06AX09
Chemical structure group: DG00956
Product (DG00956): D02572<US>
Efficacy
Antidepressant, Selective noradrenaline reuptake inhibitor (NRI)
Target
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
  Pathway
hsa04721  Synaptic vesicle cycle
Metabolism
Enzyme: CYP2D6 [HSA:1565], UGT1A9 [HSA:54600], UGT2B15 [HSA:7366]
Interaction
Structure map
map07027  Antidepressants
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX09 Viloxazine
      D08673  Viloxazine (INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG03085  Selective norepinephrine reuptake inhibitor (NRI)
   DG00956  Viloxazine
    D08673  Viloxazine
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00956  Viloxazine
    D08673  Viloxazine
  DG02924  UGT substrate
   DG03188  UGT1A9 substrate
    DG00956  Viloxazine
     D08673  Viloxazine
   DG03187  UGT2B15 substrate
    DG00956  Viloxazine
     D08673  Viloxazine
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D08673  Viloxazine (INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D08673
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG03085  Selective norepinephrine reuptake inhibitor (NRI)
   DG00956  Viloxazine
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00956  Viloxazine
  DG02924  UGT substrate
   DG03188  UGT1A9 substrate
    DG00956  Viloxazine
   DG03187  UGT2B15 substrate
    DG00956  Viloxazine
Other DBs
CAS: 46817-91-8
PubChem: 96025356
LigandBox: D08673
NIKKAJI: J16.881E
KCF data

ATOM        17
            1   O2a O    15.8960  -17.7163
            2   C1b C    14.6356  -18.4165
            3   C1y C    13.4452  -17.7163
            4   O2x O    12.2548  -18.4165
            5   C1x C    10.9943  -17.7163
            6   C1x C    10.9943  -16.3158
            7   N1x N    12.2548  -15.6155
            8   C1x C    13.4452  -16.3158
            9   C8y C    15.8960  -16.3158
            10  C8y C    17.0865  -15.6155
            11  C8x C    17.0865  -14.2150
            12  C8x C    15.8960  -13.5148
            13  C8x C    14.7056  -14.2150
            14  C8x C    14.7056  -15.6155
            15  O2a O    18.2769  -16.3158
            16  C1b C    19.4673  -15.6155
            17  C1a C    20.7277  -16.3158
BOND        18
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     6   7 1
            7     7   8 1
            8     3   8 1
            9     1   9 1
            10    9  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14   13  14 2
            15    9  14 1
            16   10  15 1
            17   15  16 1
            18   16  17 1

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (1)   
   KEGG PATHWAY (1)   
Drug (2)   
   KEGG DGROUP (1)   
   LigandBox (1)   
Chemical substance (8)   
   PubChem (1)   
   MASSBANK (6)   
   NIKKAJI (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
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