KEGG   DRUG: Voclosporin
Entry
D09033                      Drug                                   
Name
Voclosporin (JAN/USAN/INN);
Lupkynis (TN)
Product
LUPKYNIS (Aurinia Pharma U.S.)
Formula
C63H111N11O12
Exact mass
1213.8414
Mol weight
1214.6219
Structure
Simcomp
Class
Immunological agent
 DG03129  Calcineurin inhibitor
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
ATC code: L04AD03
Product: D09033<US>
Efficacy
Immunosuppressant, Calcineurin inhibitor
  Disease
Lupus nephritis [DS:H01500]
Comment
Cyclosporine [DR:D00184] analog
Target
PPP3C/PPP3R/CHP [HSA:5530 5532 5533 5534 5535 11261 63928] [KO:K04348 K06268 K17610 K17611]
  Pathway
hsa04010  MAPK signaling pathway
hsa04218  Cellular senescence
hsa04380  Osteoclast differentiation
hsa04650  Natural killer cell mediated cytotoxicity
hsa04658  Th1 and Th2 cell differentiation
hsa04659  Th17 cell differentiation
hsa04660  T cell receptor signaling pathway
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AD Calcineurin inhibitors
     L04AD03 Voclosporin
      D09033  Voclosporin (JAN/USAN/INN) <US>
USP drug classification [BR:br08302]
 Immunological Agents
  Immunosuppressants
   Calcineurin Inhibitors
    Voclosporin
     D09033  Voclosporin (JAN/USAN/INN)
Drug groups [BR:br08330]
 Immunological agent
  DG03129  Calcineurin inhibitor
   D09033  Voclosporin
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D09033  Voclosporin
Drug classes [BR:br08332]
 Immunological agent
  DG03129  Calcineurin inhibitor
   D09033  Voclosporin
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Phosphatases
    PPP3C/PPP3R/CHP
     D09033  Voclosporin (JAN/USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D09033
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D09033
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09033
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D09033
Other DBs
CAS: 515814-01-4
PubChem: 96025716
LigandBox: D09033
KCF data

ATOM        86
            1   C1c C    28.3500  -15.1200
            2   N1c N    27.3000  -15.7500
            3   C5a C    29.4700  -15.7500
            4   C1c C    28.3500  -13.8600
            5   C5a C    26.1800  -15.1200
            6   C1a C    27.3000  -17.0100
            7   N1b N    30.5900  -15.1200
            8   O5a O    29.4700  -17.0100
            9   C1c C    29.4700  -13.2300
            10  O1a O    27.3000  -13.2300
            11  C1c C    25.1300  -15.7500
            12  O5a O    26.1800  -13.8600
            13  C1c C    31.6400  -15.7500
            14  C1a C    30.5900  -13.8600
            15  N1c N    24.0100  -15.1200
            16  C1c C    25.1300  -17.4300
            17  C5a C    32.7600  -15.1200
            18  C1b C    31.6400  -17.0100
            19  C5a C    22.8900  -15.7500
            20  C1a C    24.0100  -13.8600
            21  C1a C    24.0800  -18.0600
            22  C1a C    26.2500  -18.0600
            23  N1c N    33.8100  -15.7500
            24  O5a O    32.7600  -13.8600
            25  C1c C    21.8400  -15.1200
            26  O5a O    22.8900  -17.0100
            27  C1b C    33.8100  -17.0100
            28  C1a C    34.9300  -15.1200
            29  N1c N    20.7200  -15.7500
            30  C1b C    21.8400  -13.8600
            31  C5a C    34.9300  -17.6400
            32  C5a C    20.7200  -19.1100
            33  C1a C    19.4600  -15.7500
            34  C1c C    20.7200  -13.2300
            35  N1c N    34.9300  -19.2500
            36  O5a O    36.0500  -17.0100
            37  C1c C    19.6700  -20.9300
            38  C1a C    20.7200  -11.9700
            39  C1a C    19.6700  -13.8600
            40  C1c C    34.9300  -22.1900
            41  C1a C    36.1900  -19.2500
            42  N1c N    19.6700  -22.1900
            43  C1b C    18.5500  -20.3000
            44  C5a C    33.8100  -22.8200
            45  C1b C    36.0500  -22.8200
            46  C5a C    20.7200  -22.8200
            47  C1a C    18.5500  -22.8200
            48  C1c C    17.4300  -20.9300
            49  N1b N    32.7600  -22.1900
            50  O5a O    33.8100  -24.0800
            51  C1c C    37.1000  -22.1900
            52  C1c C    21.8400  -22.1900
            53  O5a O    20.7200  -24.0800
            54  C1a C    16.3800  -20.3000
            55  C1c C    31.6400  -22.8200
            56  C1a C    38.2200  -22.8200
            57  C1a C    37.1000  -20.9300
            58  N1b N    22.8900  -22.8200
            59  C1a C    21.8400  -21.0000
            60  C5a C    30.5900  -22.1900
            61  C1c C    31.6400  -24.5000
            62  C5a C    24.0100  -22.1900
            63  N1c N    29.4700  -22.8200
            64  O5a O    30.5900  -20.9300
            65  C1a C    30.5200  -25.4100
            66  C1a C    32.7600  -25.3400
            67  C1c C    25.1300  -22.8200
            68  O5a O    24.0100  -20.9300
            69  C1c C    28.3500  -22.1900
            70  C1a C    29.4700  -24.0800
            71  N1b N    26.1800  -22.1900
            72  C1a C    25.1300  -24.0800
            73  C5a C    27.3000  -22.8200
            74  C1b C    28.3500  -19.8800
            75  O5a O    27.3000  -24.0800
            76  C1c C    29.4700  -19.2500
            77  C1a C    29.4700  -17.9900
            78  C1a C    30.5900  -19.8800
            79  C1a C    32.8300  -17.7100
            80  C1a C    17.4300  -22.3300
            81  O5a O    21.9100  -19.8100
            82  C1b C    29.4700  -11.8300
            83  C2b C    30.6600  -11.1300
            84  C2b C    31.8500  -11.8300
            85  C2b C    33.0400  -11.1300
            86  C2a C    34.2581  -11.8201
BOND        86
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 2
            8     4   9 1
            9     4  10 1 #Down
            10    5  11 1
            11    5  12 2
            12    7  13 1
            13    9  14 1 #Up
            14   11  15 1
            15   11  16 1 #Down
            16   13  17 1
            17   13  18 1 #Down
            18   15  19 1
            19   15  20 1
            20   16  21 1
            21   16  22 1
            22   17  23 1
            23   17  24 2
            24   19  25 1
            25   19  26 2
            26   23  27 1
            27   23  28 1
            28   25  29 1
            29   25  30 1 #Up
            30   27  31 1
            31   29  32 1
            32   29  33 1
            33   30  34 1
            34   31  35 1
            35   31  36 2
            36   34  38 1
            37   34  39 1
            38   35  40 1
            39   35  41 1
            40   37  42 1
            41   37  43 1 #Up
            42   40  44 1
            43   40  45 1 #Up
            44   42  46 1
            45   42  47 1
            46   43  48 1
            47   44  49 1
            48   44  50 2
            49   45  51 1
            50   46  52 1
            51   46  53 2
            52   48  54 1
            53   49  55 1
            54   51  56 1
            55   51  57 1
            56   52  58 1
            57   52  59 1 #Up
            58   55  60 1
            59   55  61 1 #Up
            60   58  62 1
            61   60  63 1
            62   60  64 2
            63   61  65 1
            64   61  66 1
            65   62  67 1
            66   62  68 2
            67   63  69 1
            68   63  70 1
            69   67  71 1
            70   67  72 1 #Up
            71   69  73 1
            72   69  74 1 #Down
            73   73  75 2
            74   74  76 1
            75   76  77 1
            76   76  78 1
            77   71  73 1
            78   18  79 1
            79   48  80 1
            80   32  81 2
            81   37  32 1
            82    9  82 1
            83   82  83 1
            84   83  84 2
            85   84  85 1
            86   85  86 2

» Japanese version   » Back

  All links  
Ontology (9)   
   KEGG BRITE (9)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (3)   
   KEGG DGROUP (2)   
   LigandBox (1)   
Chemical substance (1)   
   PubChem (1)   
Gene (11)   
   KEGG ORTHOLOGY (4)   
   KEGG GENES (7)   
All databases (25)   

Download RDF
DBGET integrated database retrieval system