KEGG   DRUG: Blinatumomab
Entry
D09325                      Drug                                   
Name
Blinatumomab (USAN/INN);
Blinatumomab (genetical recombination) (JAN);
Blincyto (TN)
Product
BLINCYTO (Amgen)
Formula
C2367H3577N649O772S19
Exact mass
54052.5286
Mol weight
54085.8484
Remark
Therapeutic category: 4291
ATC code: L01FX07
Product: D09325<JP/US>
Efficacy
Antineoplastic, Anti-CD19 and CD3 antibody
  Disease
B-cell precursor acute lymphoblastic leukemia (Philadelphia chromosome-negative) [DS:H00001]
  Type
Monoclonal antibody, bispecific antibody
Target
CD19 [HSA:930] [KO:K06465]
CD3 [HSA:915 916 917] [KO:K06450 K06451 K06452]
  Pathway
hsa04660  T cell receptor signaling pathway
hsa04662  B cell receptor signaling pathway
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01F MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES
    L01FX Other monoclonal antibodies and antibody drug conjugates
     L01FX07 Blinatumomab
      D09325  Blinatumomab (USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Monoclonal Antibody/Antibody-Drug Conjugate
   Blinatumomab
    D09325  Blinatumomab (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D09325  Blinatumomab (USAN/INN); Blinatumomab (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Cell surface molecules and ligands
  Other cell surface molecules
   CD molecules
    CD3
     D09325  Blinatumomab (USAN/INN) <JP/US>
    CD19
     D09325  Blinatumomab (USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D09325
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D09325
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D09325
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09325
Pharmacogenomic biomarkers [br08341.html]
 Somatic variations in targeted cancer therapies
  D09325
Other DBs
CAS: 853426-35-4
PubChem: 96026005

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Ontology (9)   
   KEGG BRITE (9)   
Disease (1)   
   KEGG DISEASE (1)   
Chemical substance (1)   
   PubChem (1)   
Gene (8)   
   KEGG ORTHOLOGY (4)   
   KEGG GENES (4)   
All databases (19)   

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