KEGG   DRUG: Brentuximab vedotin
Entry
D09587                      Drug                                   
Name
Brentuximab vedotin (USAN/INN);
Brentuximab vedotin (genetical recombination) (JAN);
Adcetris (TN)
Product
ADCETRIS (SEAGEN)
Formula
C6476H9930N1690O2030S40. (C68H105N11O15)n
Sequence
  Type
Peptide
Remark
Therapeutic category: 4291
ATC code: L01FX05
Product: D09587<JP/US>
Efficacy
Antineoplastic, Tubulin polymerization inhibitor, Anti-CD30 antibody
  Disease
Hodgkin lymphoma [DS:H00007]
Anaplastic large cell lymphoma [DS:H01601]
Peripheral T-cell lymphoma (CD30 expressing) [DS:H01892]
Mycosis fungoides (CD30 expressing) [DS:H01463]
  Type
Antibody-drug conjugate
Comment
See Vedotin [DR:D09691]
Target
TNFRSF8 (CD30) [HSA:943] [KO:K05145]
TUBB [HSA:10381 10382 10383 203068 347688 347733 7280 81027 84617] [KO:K07375]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01F MONOCLONAL ANTIBODIES AND ANTIBODY DRUG CONJUGATES
    L01FX Other monoclonal antibodies and antibody drug conjugates
     L01FX05 Brentuximab vedotin
      D09587  Brentuximab vedotin (USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Monoclonal Antibody/Antibody-Drug Conjugate
   Brentuximab Vedotin
    D09587  Brentuximab vedotin (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D09587  Brentuximab vedotin (USAN/INN); Brentuximab vedotin (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   Tumor necrosis factor receptors
    TNFRSF8 (CD30)
     D09587  Brentuximab vedotin (USAN/INN) <JP/US>
 Not elsewhere classified
  Cellular process
   Cytoskeleton
    TUBB
     D09587  Brentuximab vedotin (USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D09587
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D09587
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D09587
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D09587
Pharmacogenomic biomarkers [br08341.html]
 Somatic variations in targeted cancer therapies
  D09587
Other DBs
CAS: 914088-09-8
PubChem: 124490327

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