KEGG   DRUG: Luseogliflozin hydrate
Entry
D10195                      Drug                                   
Name
Luseogliflozin hydrate (JAN);
Lusefi (TN)
Formula
C23H30O6S. xH2O
Structure
Class
Antidiabetic agent
 DG02044  Hypoglycemic agent
  DG01794  SGLT2 inhibitor
Remark
Therapeutic category: 3969
ATC code: A10BK07
Product: D10195<JP>
Efficacy
Antidiabetic, SGLT-2 inhibitor
Comment
Phlorizin derivative
Target
SLC5A2 (SGLT2) [HSA:6524] [KO:K14382]
Interaction
Structure map
map07051  Antidiabetics
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BK Sodium-glucose co-transporter 2 (SGLT2) inhibitors
     A10BK07 Luseogliflozin
      D10195  Luseogliflozin hydrate (JAN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   396  Antidiabetic agents
    3969  Others
     D10195  Luseogliflozin hydrate (JAN)
Drug groups [BR:br08330]
 Antidiabetic agent
  DG02044  Hypoglycemic agent
   DG01794  SGLT2 inhibitor
    D10195  Luseogliflozin hydrate
Drug classes [BR:br08332]
 Antidiabetic agent
  DG01794  SGLT2 inhibitor
   D10195  Luseogliflozin hydrate
  DG02044  Hypoglycemic agent
   D10195  Luseogliflozin hydrate
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC5
    SLC5A2 (SGLT2)
     D10195  Luseogliflozin hydrate (JAN) <JP>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D10195
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D10195
Other DBs
PubChem: 135626913
LigandBox: D10195
KCF data

ATOM        31
            1   S2x S    14.1400  -14.7700
            2   C1y C    14.1400  -16.1700
            3   C1y C    12.9500  -16.8700
            4   C1y C    11.6900  -16.1700
            5   C1y C    11.6900  -14.7700
            6   C1y C    12.9500  -14.0700
            7   C1b C    12.9500  -12.6700
            8   O1a O    10.5000  -14.0700
            9   O1a O    12.9500  -18.2700
            10  O1a O    10.5000  -16.8700
            11  C8y C    15.3300  -16.8700
            12  C8x C    16.5200  -16.1700
            13  C8y C    17.7800  -16.8700
            14  C8y C    17.7800  -18.2700
            15  C8x C    16.5900  -18.9700
            16  C8y C    15.3300  -18.2700
            17  O2a O    14.1400  -18.9700
            18  C1a C    14.1400  -20.3700
            19  C1b C    18.9700  -16.1700
            20  C8y C    20.1600  -16.8700
            21  C8x C    22.6100  -16.8700
            22  C8y C    22.6100  -18.2700
            23  C8x C    21.4200  -18.9700
            24  C8x C    20.1600  -18.2700
            25  C8x C    21.3500  -16.1700
            26  O2a O    23.8000  -18.9700
            27  C1b C    24.9900  -18.2700
            28  C1a C    26.1800  -18.9700
            29  O1a O    14.1624  -11.9700
            30  C1a C    18.9953  -18.9651
            31  O0  O    25.4800  -13.0200
BOND        32
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     6   7 1 #Up
            8     5   8 1 #Down
            9     3   9 1 #Down
            10    4  10 1 #Up
            11    2  11 1 #Up
            12   11  12 1
            13   12  13 2
            14   13  14 1
            15   14  15 2
            16   15  16 1
            17   11  16 2
            18   16  17 1
            19   17  18 1
            20   13  19 1
            21   19  20 1
            22   21  22 1
            23   22  23 2
            24   23  24 1
            25   20  24 2
            26   20  25 1
            27   25  21 2
            28   22  26 1
            29   26  27 1
            30   27  28 1
            31    7  29 1
            32   14  30 1
BRACKET     1    23.4500  -13.8600   23.4500  -11.9700
            1    26.0400  -11.9700   26.0400  -13.8600
            1  x
 ORIGINAL  1   31
 REPEAT    1

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