KEGG   DISEASE: H00017Help
Entry
H00017                      Disease                                

Name
Esophageal cancer
Description
Esophageal cancer represents the 9th leading cancer in the world and is associated with a 5-year survival rate under 25%. The two main forms are squamous-cell carcinoma (ECSC) and adenocarcinoma (EAC). ECSC is the most frequent histological subtype in esophageal cancer, although the incidence of EAC is increasing faster than any other malignancy in the western world. Whereas ESCC can be attributed to alcohol and tobacco consumption, the most important risk factor for the development of EAC is duodenal-gastric-esophageal reflux. In the process of tumorigenesis at the cellular level, multiple genetic alterations are involved, including mutation of the p53 gene, amplification of cyclin D1 gene, among others.
Category
Cancer
BRITE hierarchy
Pathway
MicroRNAs in cancer
Gene
EGFR (overexpression) [HSA:1956] [KO:K04361]
p53 (mutation) [HSA:7157] [KO:K04451]
p16/INK4A (homozygous deletion, LOH) [HSA:1029] [KO:K06621]
RB1 (LOH) [HSA:5925] [KO:K06618]
iNOS (increased expression) [HSA:4843] [KO:K13241]
COX2 (overexpression) [HSA:5743] [KO:K11987]
APC (LOH) [HSA:324] [KO:K02085]
Cyclin D1 (amplification) [HSA:595] [KO:K04503]
FAS (increased expression) [HSA:355] [KO:K04390]
Carcinogen
Betel quid with tobacco
Betel quid without tobacco
Ethanol in alcoholic beverages [CPD:C00469]
Marker
p53 [HSA:7157]
TGF-alpha [HSA:7039]
Drug
Fluorouracil [DG:DG00687]
Cisplatin [DR:D00275]
Mitomycin [DR:D00208]
Comment
ICD-O: 8070/3, Tumor type: Squamous cell carcinoma
ICD-O: 8140/3, Tumor type: Adenocarcinoma
Other DBs
ICD-10: 
MeSH: 
Reference
PMID:15622457 (gene, tumor type)
  Authors
Kuwano H, Kato H, Miyazaki T, Fukuchi M, Masuda N, Nakajima M, Fukai Y, Sohda M, Kimura H, Faried A.
  Title
Genetic alterations in esophageal cancer.
  Journal
Surg Today 35:7-18 (2005)
Reference
PMID:12951586 (gene, tumor type)
  Authors
Wild CP, Hardie LJ.
  Title
Reflux, Barrett's oesophagus and adenocarcinoma: burning questions.
  Journal
Nat Rev Cancer 3:676-84 (2003)
Reference
PMID:15914317 (gene)
  Authors
McCabe ML, Dlamini Z.
  Title
The molecular mechanisms of oesophageal cancer.
  Journal
Int Immunopharmacol 5:1113-30 (2005)
Reference
PMID:15455377 (carcinogen)
  Authors
Lee CH, Lee JM, Wu DC, Hsu HK, Kao EL, Huang HL, Wang TN, Huang MC, Wu MT.
  Title
Independent and combined effects of alcohol intake, tobacco smoking and betel quid chewing on the risk of esophageal cancer in Taiwan.
  Journal
Int J Cancer 113:475-82 (2005)
Reference
PMID:17431955 (carcinogen)
  Authors
Baan R, Straif K, Grosse Y, Secretan B, El Ghissassi F, Bouvard V, Altieri A, Cogliano V.
  Title
Carcinogenicity of alcoholic beverages.
  Journal
Lancet Oncol 8:292-3 (2007)
Reference
PMID:17383866 (carcinogen)
  Authors
Lee CH, Wu DC, Lee JM, Wu IC, Goan YG, Kao EL, Huang HL, Chan TF, Chou SH, Chou YP, Lee CY, Chen PS, Ho CK, He J, Wu MT.
  Title
Carcinogenetic impact of alcohol intake on squamous cell carcinoma risk of the oesophagus in relation to tobacco smoking.
  Journal
Eur J Cancer 43:1188-99 (2007)
Reference
PMID:11565671 (marker)
  Authors
Aloia TA, Harpole DH Jr, Reed CE, Allegra C, Moore MB, Herndon JE 2nd, D'Amico TA.
  Title
Tumor marker expression is predictive of survival in patients with esophageal cancer.
  Journal
Ann Thorac Surg 72:859-66 (2001)
Reference
PMID:17069584 (marker)
  Authors
Vallbohmer D, Lenz HJ.
  Title
Predictive and prognostic molecular markers in outcome of esophageal cancer.
  Journal
Dis Esophagus 19:425-32 (2006)
Reference
(drug)
  Authors
McPhee SJ, Papadakis MA, Tierney LM (ed).
  Title
Current Medical Diagnosis & Treatment 2007, Forty-Sixth Edition
  Journal
The McGraw-Hill Companies, Inc. (2007)

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