KEGG   DISEASE: ChoriocarcinomaHelp
Entry
H00028                      Disease                                

Name
Choriocarcinoma
Description
Gestational choriocarcinoma is a highly malignant epithelial tumor that can be associated with any type of gestational event, most often a complete hydatidiform mole (CM). CM occur in about one per 1000 pregnancies, and about 5-20% of CM progress to invasive moles or choriocarcinoma. Several molecular studies have been done to establish the expression of tumor-associated proteins in choriocarcinoma. In the p53 pathway, overexpression of the p53 protein and the p53-associated protein, MDM2, have been detected. Synergistic upregulation of c-MYC, c-ERB-2, c-FMS, and BCL-2 oncoproteins have also been suggested to have an important role in the pathogenesis of choriocarcinoma. Moreover, choriocarcinomas have been shown to express increased concentrations of MMP and decreased concentrations of TIMP to help with tumor invasion and metastasis.
Category
Cancer
Brite
Human diseases [BR:br08402]
 Cancers
  Cancers of the breast and female genital organs
   H00028  Choriocarcinoma
Human diseases in ICD-10 classification [BR:br08403]
 2. Neoplasms (C00-D48)
  C51-C58  Malignant neoplasms of female genital organs
   C58  Malignant neoplasm of placenta
    H00028  Choriocarcinoma
Tumor markers [br08442.html]
 H00028
BRITE hierarchy
Gene
p53 (overexpression) [HSA:7157] [KO:K04451]
MdM2 (overexpression) [HSA:4193] [KO:K06643]
EGFR (overexpression) [HSA:1956] [KO:K04361]
c-MYC (overexpression) [HSA:4609] [KO:K04377]
ERBB2 (overexpression) [HSA:2064] [KO:K05083]
c-FMS (overexpression) [HSA:1436] [KO:K05090]
Bcl-2 (overexpression) [HSA:596] [KO:K02161]
MMP-1 (overexpression) [HSA:4312] [KO:K01388]
MMP-2 (overexpression) [HSA:4313] [KO:K01398]
Marker
Beta-human chorionic gonadotropin (Beta-hCG) [HSA:1082] [KO:K10045]
Drug
Methotrexate [DG:DG00681]
Dactinomycin [DR:D00214]
Etoposide [DG:DG00693]
Cyclophosphamide [DG:DG00675]
Vincristine [DG:DG00690]
Comment
ICD-O: 9100/3, Tumor type: Choriocarcinoma
Other DBs
ICD-10: 
MeSH: 
Reference
PMID:17613426 (description, gene, tumor type)
  Authors
Shih IeM.
  Title
Gestational trophoblastic neoplasia--pathogenesis and potential therapeutic targets.
  Journal
Lancet Oncol 8:642-50 (2007)
DOI:10.1016/S1470-2045(07)70204-8
Reference
PMID:11869089 (description, gene)
  Authors
Li HW, Tsao SW, Cheung AN
  Title
Current understandings of the molecular genetics of gestational trophoblastic diseases.
  Journal
Placenta 23:20-31 (2002)
DOI:10.1053/plac.2001.0744
Reference
PMID:17304028 (gene, tumor type)
  Authors
Garner EI, Goldstein DP, Feltmate CM, Berkowitz RS.
  Title
Gestational trophoblastic disease.
  Journal
Clin Obstet Gynecol 50:112-22 (2007)
DOI:10.1097/GRF.0b013e31802f17fc
Reference
(drug)
  Authors
Papadakis MA and McPhee SJ |(ed)
  Title
Current Medical Diagnosis & Treatment 2015, Fifty-Fourth Edition
  Journal
McGraw Hill Education

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