KEGG   DISEASE: H00030Help
Entry
H00030                      Disease                                

Name
Cervical cancer
Description
Cervical cancer is the second largest cause of cancer-related death in women worldwide, and it occurs following persistent infection, sometimes for decades, with a specific subset of human papillomavirus (HPV) types, particularly types 16, 18, 33 and 42. Experimental studies show that the E6 and E7 genes of these high risk HPVs are oncogenes that deregulate key cell cycle controls. The E6 and E7 oncoproteins bind respectively to the p53 and Retinoblastoma (Rb) tumor suppressor proteins, which are involved in the regulation of growth control. The abnormalities in other cellular genes found in cervical cancer, including mutations in ras family of genes, and amplification in EGFR and ERBB2, may also play an important role in carcinogenesis and the aggressiveness of cervical tumors, although to date the role of most of these genetic abnormalities does not appear to be as important as the role of HPV.
Category
Cancer
BRITE hierarchy
Pathway
Viral carcinogenesis
Gene
K-ras (mutation) [HSA:3845] [KO:K07827]
H-ras (mutation) [HSA:3265] [KO:K02833]
EGFR (amplification) [HSA:1956] [KO:K04361]
ERBB2 (amplification) [HSA:2064] [KO:K05083]
p21 (overexpression) [HSA:1026] [KO:K06625]
CDK4 (overexpression) [HSA:1019] [KO:K02089]
Bcl-2 (overexpression) [HSA:596] [KO:K02161]
Carcinogen
Azathioprine [DR:D00238]
Diethylstilboestrol [CPD:C07620] [DR:D00577]
Estrogens, nonsteroidal
Tobacco smoking and tobacco smoke
Pathogen
Human papillomavirus types 16, 18 [VGNM:NC_001526 NC_001357]
Marker
HPV (Human papillomavirus) DNA (L1) [VG:NC_001526_8]
SCC antigen [HSA:6317]
CYFRA [HSA:3880]
Drug
Methotrexate [DR:D00142 D02115]
Doxorubicin [DR:D03899 D01275]
Cisplatin [DR:D00275]
Vinblastine [DR:D01068]
Mitomycin [DR:D00208]
Bleomycin [DR:D02177 D03229]
Vincristine [DR:D02197]
Comment
ICD-O: 8070/3, Tumor type: Squamous cell carcinoma, not otherwise specified
ICD-O: 8140/3, Tumor type: Adenocarcinoma
Other DBs
ICD-10: 
MeSH: 
Reference
PMID:11486705 (gene, carcinogen)
  Authors
Wolf JK, Ramirez PT.
  Title
The molecular biology of cervical cancer.
  Journal
Cancer Invest 19:621-9 (2001)
Reference
PMID:10471054 (gene, carcinogen)
  Authors
Lazo PA.
  Title
The molecular genetics of cervical carcinoma.
  Journal
Br J Cancer 80:2008-18 (1999)
Reference
PMID:16062089 (carcinogen)
  Authors
Patel P, Moazzam N, Potti A, Mehdi SA.
  Title
Azathioprine induced hodgkin lymphoma: a case report and review of literature.
  Journal
Am J Clin Oncol 28:427-8 (2005)
Reference
PMID:15168959 (carcinogen)
  Authors
Schrager S, Potter BE.
  Title
Diethylstilbestrol exposure.
  Journal
Am Fam Physician 69:2395-400 (2004)
Reference
PMID:17390375 (carcinogen)
  Authors
Troisi R, Hatch EE, Titus-Ernstoff L, Hyer M, Palmer JR, Robboy SJ, Strohsnitter WC, Kaufman R, Herbst AL, Hoover RN.
  Title
Cancer risk in women prenatally exposed to diethylstilbestrol.
  Journal
Int J Cancer 121:356-60 (2007)
Reference
PMID:11281434 (carcinogen)
  Authors
Severson J, Evans TY, Lee P, Chan T, Arany I, Tyring SK.
  Title
Human papillomavirus infections: epidemiology, pathogenesis, and therapy.
  Journal
J Cutan Med Surg 5:43-60 (2001)
Reference
PMID:15489140 (carcinogen)
  Authors
Wogan GN, Hecht SS, Felton JS, Conney AH, Loeb LA.
  Title
Environmental and chemical carcinogenesis.
  Journal
Semin Cancer Biol 14:473-86 (2004)
Reference
PMID:15552776 (carcinogen)
  Authors
Sasco AJ, Secretan MB, Straif K.
  Title
Tobacco smoking and cancer: a brief review of recent epidemiological evidence.
  Journal
Lung Cancer 45 Suppl 2:S3-9 (2004)
Reference
PMID:12612656 (marker)
  Authors
Baldwin P, Laskey R, Coleman N.
  Title
Translational approaches to improving cervical screening.
  Journal
Nat Rev Cancer 3:217-26 (2003)
Reference
PMID:12797857 (marker)
  Authors
Garland SM.
  Title
Can we really beat cervical cancer?
  Journal
Med J Aust 178:647-9 (2003)
Reference
PMID:14739059 (marker)
  Authors
Gadducci A, Cosio S, Carpi A, Nicolini A, Genazzani AR.
  Title
Serum tumor markers in the management of ovarian, endometrial and cervical cancer.
  Journal
Biomed Pharmacother 58:24-38 (2004)
Reference
(drug, tumor type)
  Authors
McPhee SJ, Papadakis MA, Tierney LM (ed).
  Title
Current Medical Diagnosis & Treatment 2007, Forty-Sixth Edition
  Journal
The McGraw-Hill Companies, Inc. (2007)

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