Kaposi sarcoma (KS) is an angioproliferative disease classified into classic KS, endemic KS, iatrogenic KS, and HIV-associated KS (HIV-KS), however, they share the same histological traits and are all associated with infection by the human herpesvirus 8 (HHV8; also known as KSHV). Evidence indicates that KS progression occurs upon the deregulated expression of anti-apoptotic genes (Bcl-2), oncogenes (c-myc, c-int, ras) and oncosuppressor genes (TP53), and is associated with the long-lasting expression of HHV8 latency genes (LANA, v-cyc D, v-FLIP, Kaposin). All these genes are, in fact, expressed or altered in most KS spindle cells in the nodular-late stage of KS. Bcl-2 acts as a major KS progression factor, and TP53 and c-myc may also have a role in disease progression. HHV8 latency gene products may be involved in KS progression due to their capability of promoting cell growth by direct effects or antiapoptotic effects.
Category
Cancer; Viral infectious disease
Brite
Human diseases in ICD-11 classification [BR:br08403]
02 Neoplasms
Malignant neoplasms, except primary neoplasms of lymphoid, haematopoietic, central nervous system or related tissues
Malignant neoplasms, stated or presumed to be primary, of specified sites, except of lymphoid, haematopoietic, central nervous system or related tissues
Malignant mesenchymal neoplasms
2B57 Kaposi sarcoma, primary site
H00041 Kaposi sarcoma
Pathway-based classification of diseases [BR:br08402]
Signal transduction
nt06505 WNT signaling
H00041 Kaposi sarcoma
nt06518 JAK-STAT signaling
H00041 Kaposi sarcoma
nt06516 TNF signaling
H00041 Kaposi sarcoma
Cellular process
nt06532 Autophagy
H00041 Kaposi sarcoma
nt06524 Apoptosis
H00041 Kaposi sarcoma
Immune system
nt06513 Complement cascade
H00041 Kaposi sarcoma
nt06517 TLR signaling
H00041 Kaposi sarcoma
nt06533 Chemokine signaling
H00041 Kaposi sarcoma
Genome-based classification of infectious diseases [BR:br08401]
Viral infections
Infections caused by dsDNA viruses
H00041 Kaposi sarcoma
