KEGG   DISEASE: Kaposi's sarcomaHelp
Entry
H00041                      Disease                                

Name
Kaposi's sarcoma
Description
Kaposi's sarcoma (KS) is an angioproliferative disease classified into classic KS, endemic KS, iatrogenic KS, and HIV-associated KS (HIV-KS), however, share the same histological traits and are all associated with infection by the human herpesvirus 8 (HHV8; also known as KSHV). Evidence indicates that KS progression occurs upon the deregulated expression of anti-apoptotic genes (Bcl-2), oncogenes (c-myc, c-int, ras) and oncosuppressor genes (TP53), and is associated with the long-lasting expression of HHV8 latency genes (LANA, v-cyc D, v-FLIP, Kaposin). All these genes are, in fact, expressed or altered in most KS spindle cells in the nodular-late stage of KS. Bcl-2 acts as a major KS progression factor, and TP53 and c-myc may also have a role in disease progression. HHV8 latency gene products may be involved in KS progression due to their capability of promoting cell growth by direct effects or antiapoptotic effects.
Category
Cancer
Brite
Human diseases [BR:br08402]
 Cancers
  Cancers of soft tissues and bone
   H00041  Kaposi's sarcoma
Infectious diseases [BR:br08401]
 Viral infections
  Infections caused by dsDNA viruses
   H00041  Kaposi's sarcoma
Human diseases in ICD-10 classification [BR:br08403]
 2. Neoplasms (C00-D48)
  C45-C49  Malignant neoplasms of mesothelial and soft tissue
   C46  Kaposi's sarcoma
    H00041  Kaposi's sarcoma
BRITE hierarchy
Pathway
Kaposi's sarcoma-associated herpesvirus infection
Viral carcinogenesis
Network
N00157  
KSHV vGPCR to GNB/G-ERK signaling pathway
N00158  
KSHV vGPCR to GNB/G-PI3K-AKT signaling pathway
N00159  
KSHV K1 to PI3K signaling pathway
N00160  
KSHV K1 to RAS-ERK signaling pathway
N00161  
KSHV vIRF1/2 to TLR3-IRF3 signaling pathway
N00162  
KSHV vIRF3 to TLR3-IRF7 signaling pathway
N00163  
KSHV KIE1/2 to TLR3-IRF7 signaling pathway
N00164  
KSHV vBCL2 to crosstalk between extrinsic and intrinsic apoptotic pathways
N00165  
KSHV vIAP to crosstalk between extrinsic and intrinsic apoptotic pathways
N00166  
KSHV vFLIP to crosstalk between extrinsic and intrinsic apoptotic pathways
N00167  
KSHV vIRF1/3 to p21-cell cycle G1/S
N00168  
KSHV vCyclin to cell cycle G1/S
N00169  
KSHV LANA to p21-cell cycle G1/S
N00170  
KSHV LANA to cell cycle G1/S
N00171  
KSHV vFLIP to NFKB signaling pathway
N00172  
KSHV K15 to PLCG-calcineurin signaling pathway
N00173  
KSHV K15 to NFKB signaling pathway
N00174  
KSHV vFLIP to TNF-NFKB signaling pathway
N00175  
KSHV LANA to Wnt signaling pathway
N00176  
KSHV vFLIP to autophagy-vesicle elongation
N00177  
KSHV vBCL2 to autophagy-vesicle nucleation
N00178  
KSHV vGPCR to GNB/G-PI3K-JNK signaling pathway
N00179  
KSHV K1 to PI3K-NFKB signaling pathway
N00180  
KSHV K1 to PLCG-calcineurin signaling pathway
N00181  
KSHV vIL-6 to Jak-STAT signaling pathway
N00184  
KSHV MIR1/2 to MHC1-endocytosis
N00185  
KSHV MIR2 to cell surface molecule-endocytosis
N00187  
KSHV Kaposin B to p38 signaling pathway
N00189  
KSHV K15 to JNK signaling pathway
N00196  
KSHV vIRF1/2/3 to host-cell-protein inhibition
N00197  
KSHV K-bZIP to host-cell-protein inhibition
N00198  
KSHV KIE1/2 to host-cell protein inhibition
N00199  
KSHV vBCL2 to host-cell-protein inhibition
N00200  
KSHV vIAP to host-cell-protein inhibition
N00201  
KSHV vFLIP to host-cell-protein activation
N00202  
KSHV vFLIP to host-cell-protein inhibition
N00203  
KSHV vCyclin to host-cell-protein activation
N00204  
KSHV LANA to host-cell-protein activation
N00205  
KSHV LANA to host-cell-protein inhibition
N00206  
KSHV vGPCR to host-cell-protein activation
N00207  
KSHV K15 to host-cell-protein activation
N00208  
KSHV K1 to host-cell-protein activation
N00209  
KSHV vIL-6 to host-cell-protein activation
N00210  
KSHV MIR1/2 to host-cell-protein inhibition
N00211  
KSHV vCCL1/2/3 to host-cell-protein activation
N00212  
KSHV vCCL2 to host-cell-protein inhibition
N00213  
KSHV KCP to host-cell-protein inhibition
N00214  
KSHV Kaposin B to host-cell-protein inhibition
N00261  
KSHV vIRF2 to IFN signaling pathway
Gene
Bcl-2 (overexpression) [HSA:596] [KO:K02161]
c-MYC (overexpression) [HSA:4609] [KO:K04377]
c-INT (overexpression, mutation) [HSA:2248] [KO:K04358]
K-ras (overexpression, mutation) [HSA:3845] [KO:K07827]
p53 (mutation) [HSA:7157] [KO:K04451]
Carcinogen
Azathioprine [DG:DG00743]
Pathogen
Human herpesvirus 8 (KSHV) [GN:T40081]
Human immunodeficiency virus 1 [GN:T40001] (infection with)
Marker
HHV-8 (cellular viremia and viral load)
Drug
Doxorubicin [DG:DG00696]
Daunorubicin [DG:DG00697]
Comment
ICD-O: 9140/3, Tumor type: Kaposi sarcoma
Other DBs
ICD-10: 
ICD-10: 
MeSH: 
Reference
PMID:11423257 (description, gene, carcinogen)
  Authors
Ensoli B, Sgadari C, Barillari G, Sirianni MC, Sturzl M, Monini P
  Title
Biology of Kaposi's sarcoma.
  Journal
Eur J Cancer 37:1251-69 (2001)
DOI:10.1016/S0959-8049(01)00121-6
Reference
PMID:15334644 (carcinogen, tumor type)
  Authors
Schwartz RA.
  Title
Kaposi's sarcoma: an update.
  Journal
J Surg Oncol 87:146-51 (2004)
DOI:10.1002/jso.20090
Reference
PMID:15760280 (carcinogen)
  Authors
Schottenfeld D, Beebe-Dimmer JL.
  Title
Advances in cancer epidemiology: understanding causal mechanisms and the evidence for implementing interventions.
  Journal
Annu Rev Public Health 26:37-60 (2005)
DOI:10.1146/annurev.publhealth.26.021304.144402
Reference
PMID:16062089 (carcinogen)
  Authors
Patel P, Moazzam N, Potti A, Mehdi SA.
  Title
Azathioprine induced hodgkin lymphoma: a case report and review of literature.
  Journal
Am J Clin Oncol 28:427-8 (2005)
Reference
PMID:17142074 (carcinogen)
  Authors
Feller L, Wood NH, Lemmer J
  Title
HIV-associated Kaposi sarcoma: pathogenic mechanisms.
  Journal
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 104:521-9 (2007)
DOI:10.1016/j.tripleo.2006.08.015
Reference
PMID:17630560 (marker)
  Authors
Anderson LA, Goedert JJ.
  Title
Tumor markers and treatments for Kaposi sarcoma.
  Journal
AIDS 21:1637-9 (2007)
DOI:10.1097/QAD.0b013e32826fb721
Reference
PMID:15578080 (marker)
  Authors
Hammock L, Reisenauer A, Wang W, Cohen C, Birdsong G, Folpe AL.
  Title
Latency-associated nuclear antigen expression and human herpesvirus-8 polymerase chain reaction in the evaluation of Kaposi sarcoma and other vascular tumors in HIV-positive patients.
  Journal
Mod Pathol 18:463-8 (2005)
DOI:10.1038/modpathol.3800221
Reference
(drug)
  Authors
Papadakis MA and McPhee SJ |(ed)
  Title
Current Medical Diagnosis & Treatment 2015, Fifty-Fourth Edition
  Journal
McGraw Hill Education

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