KEGG   DISEASE: H00041Help
Entry
H00041                      Disease                                

Name
Kaposi's sarcoma
Description
Kaposi's sarcoma (KS) is an angioproliferative disease occurring in several different clinical-epidemiological forms that, however, share the same histological traits and are all associated with infection by the human herpesvirus 8 (HHV8; also known as KSHV). Evidence indicates that KS progression occurs upon the deregulated expression of anti-apoptotic genes (Bcl-2), oncogenes (c-myc, c-int, ras) and oncosuppressor genes (TP53), and is associated with the long-lasting expression of HHV8 latency genes (LANA, v-cyc D, v-FLIP, Kaposin). All these genes are, in fact, expressed or altered in most KS spindle cells in the nodular-late stage of KS. Bcl-2 acts as a major KS progression factor, and TP53 and c-myc may also have a role in disease progression. HHV8 latency gene products may be involved in KS progression due to their capability of promoting cell growth by direct effects or antiapoptotic effects.
Category
Cancer
BRITE hierarchy
Pathway
Viral carcinogenesis
Gene
Bcl-2 (overexpression) [HSA:596] [KO:K02161]
c-MYC (overexpression) [HSA:4609] [KO:K04377]
c-INT (overexpression, mutation) [HSA:2248] [KO:K04358]
K-ras (overexpression, mutation) [HSA:3845] [KO:K07827]
p53 (mutation) [HSA:7157] [KO:K04451]
Carcinogen
Azathioprine [DG:DG00743]
Pathogen
HHV-8 (KSHV) [VGNM:NC_009333]
Human immunodeficiency virus type 1 (infection with) [VGNM:NC_001802]
Marker
HHV-8 (cellular viremia and viral load) [VGNM:NC_009333]
Drug
Doxorubicin [DG:DG00696]
Vincristine [DG:DG00690]
Vinblastine [DG:DG00689]
Comment
ICD-O: 9140/3, Tumor type: Kaposi sarcoma
Other DBs
ICD-10: 
MeSH: 
Reference
PMID:11423257 (description, gene, carcinogen)
  Authors
Ensoli B, Sgadari C, Barillari G, Sirianni MC, Sturzl M, Monini P
  Title
Biology of Kaposi's sarcoma.
  Journal
Eur J Cancer 37:1251-69 (2001)
Reference
PMID:15334644 (carcinogen, tumor type)
  Authors
Schwartz RA.
  Title
Kaposi's sarcoma: an update.
  Journal
J Surg Oncol 87:146-51 (2004)
Reference
PMID:15760280 (carcinogen)
  Authors
Schottenfeld D, Beebe-Dimmer JL.
  Title
Advances in cancer epidemiology: understanding causal mechanisms and the evidence for implementing interventions.
  Journal
Annu Rev Public Health 26:37-60 (2005)
Reference
PMID:16062089 (carcinogen)
  Authors
Patel P, Moazzam N, Potti A, Mehdi SA.
  Title
Azathioprine induced hodgkin lymphoma: a case report and review of literature.
  Journal
Am J Clin Oncol 28:427-8 (2005)
Reference
PMID:17630560 (marker)
  Authors
Anderson LA, Goedert JJ.
  Title
Tumor markers and treatments for Kaposi sarcoma.
  Journal
AIDS 21:1637-9 (2007)
Reference
PMID:15578080 (marker)
  Authors
Hammock L, Reisenauer A, Wang W, Cohen C, Birdsong G, Folpe AL.
  Title
Latency-associated nuclear antigen expression and human herpesvirus-8 polymerase chain reaction in the evaluation of Kaposi sarcoma and other vascular tumors in HIV-positive patients.
  Journal
Mod Pathol 18:463-8 (2005)
Reference
(drug)
  Authors
McPhee SJ, Papadakis MA, Tierney LM (ed).
  Title
Current Medical Diagnosis & Treatment 2007, Forty-Sixth Edition
  Journal
The McGraw-Hill Companies, Inc. (2007)

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