KEGG   DISEASE: Laryngeal cancerHelp
Entry
H00055                      Disease                                

Name
Laryngeal cancer
Description
Laryngeal cancer is one of the most common malignancies in Europe, with about 52,000 new cases per year, 90% of them occurring in men. Smoke and alcohol represent the major behavioral risk factors. Of all laryngeal cancers, some 95% are squamous cell carcinomas. Some molecular events have been described in laryngeal squamous cell carcinoma (LSCC). Although tumor suppressor inactivation of p53 and p16 is common in these tumors (about 50% each), oncogenic activation is less well characterized. Cyclin D1 and epidermal growth factor receptor amplification have been reported in one-third and one-quarter of LSCCs, respectively, both related to advanced stages, whereas c-myc could be amplified in 13% of cases although without associated overexpression.
Category
Cancer
Brite
Human diseases [BR:br08402]
 Cancers
  Head and neck cancers
   H00055  Laryngeal cancer
Human diseases in ICD-10 classification [BR:br08403]
 2. Neoplasms (C00-D48)
  C30-C39  Malignant neoplasms of respiratory and intrathoracic organs
   C32  Malignant neoplasm of larynx
    H00055  Laryngeal cancer
BRITE hierarchy
Gene
p53 (mutation) [HSA:7157] [KO:K04451]
p16/INK4A (mutation, LOH, hypermethylation) [HSA:1029] [KO:K06621]
Cyclin D1 (amplification) [HSA:595] [KO:K04503]
EGFR (amplification) [HSA:1956] [KO:K04361]
c-MYC (amplification) [HSA:4609] [KO:K04377]
Cyclin E (amplification) [HSA:898 9134] [KO:K06626]
Carcinogen
Alcoholic beverages
Betel quid with tobacco
Coal-tar pitches [CPD:C16451]
Isopropyl alcohol manufacture (strong-acid process)
Mineral oils, untreated and mildly treated
Paving and roofing with coal-tar pitch
Strong-inorganic-acid mists containing sulfuric acid
Tobacco smoking and tobacco smoke
Marker
p53 [HSA:7157]
Cyclin D1 [HSA:595]
EGFR [HSA:1956]
Drug
Cisplatin [DR:D00275]
Fluorouracil [DG:DG00687]
Paclitaxel [DG:DG01430]
Carboplatin [DR:D01363]
Docetaxel[DG:DG00694]
Cetuximab [DR:D03455]
Comment
ICD-O: 8070/3, Tumor type: Squamous cell carcinoma
Other DBs
ICD-10: 
MeSH: 
Reference
PMID:12853099 (description, gene, tumor type)
  Authors
Licitra L, Bernier J, Grandi C, Locati L, Merlano M, Gatta G, Lefebvre JL
  Title
Cancer of the larynx.
  Journal
Crit Rev Oncol Hematol 47:65-80 (2003)
DOI:10.1016/S1040-8428(03)00017-9
Reference
PMID:12536308 (description, gene, tumor type)
  Authors
Nadal A, Cardesa A.
  Title
Molecular biology of laryngeal squamous cell carcinoma.
  Journal
Virchows Arch 442:1-7 (2003)
DOI:10.1007/s00428-002-0726-6
Reference
PMID:17530489 (carcinogen)
  Authors
Abnet CC.
  Title
Carcinogenic food contaminants.
  Journal
Cancer Invest 25:189-96 (2007)
DOI:10.1080/07357900701208733
Reference
PMID:17646865 (carcinogen)
  Authors
Seitz HK, Stickel F.
  Title
Molecular mechanisms of alcohol-mediated carcinogenesis.
  Journal
Nat Rev Cancer 7:599-612 (2007)
DOI:10.1038/nrc2191
Reference
PMID:15957167 (carcinogen)
  Authors
Lee KW, Kuo WR, Tsai SM, Wu DC, Wang WM, Fang FM, Chiang FY, Ho KY, Wang LF, Tai CF, Kao EL, Chou SH, Lee CH, Chai CY, Ko YC.
  Title
Different impact from betel quid, alcohol and cigarette: risk factors for pharyngeal and laryngeal cancer.
  Journal
Int J Cancer 117:831-6 (2005)
DOI:10.1002/ijc.21237
Reference
PMID:9498904 (carcinogen)
  Authors
Boffetta P, Jourenkova N, Gustavsson P.
  Title
Cancer risk from occupational and environmental exposure to polycyclic aromatic hydrocarbons.
  Journal
Cancer Causes Control 8:444-72 (1997)
Reference
PMID:8189372 (carcinogen)
  Authors
Wong O, Foliart DE.
  Title
Epidemiological factors of cancer in Louisiana.
  Journal
J Environ Pathol Toxicol Oncol 12:171-83 (1993)
Reference
PMID:9498901 (carcinogen)
  Authors
Tolbert PE.
  Title
Oils and cancer.
  Journal
Cancer Causes Control 8:386-405 (1997)
Reference
PMID:10723042 (carcinogen)
  Authors
Stern FB, Ruder AM, Chen G.
  Title
Proportionate mortality among unionized roofers and waterproofers.
  Journal
Reference
PMID:17032693 (carcinogen)
  Authors
Hsu YM, Wu CY, Lundgren DA, Birky BK.
  Title
Size-resolved sulfuric acid mist concentrations at phosphate fertilizer manufacturing facilities in Florida.
  Journal
Ann Occup Hyg 51:81-9 (2007)
DOI:10.1093/annhyg/mel066
Reference
PMID:9498905 (carcinogen)
  Authors
Blair A, Kazerouni N.
  Title
Reactive chemicals and cancer.
  Journal
Cancer Causes Control 8:473-90 (1997)
Reference
PMID:15489140 (carcinogen)
  Authors
Wogan GN, Hecht SS, Felton JS, Conney AH, Loeb LA.
  Title
Environmental and chemical carcinogenesis.
  Journal
Semin Cancer Biol 14:473-86 (2004)
DOI:10.1016/j.semcancer.2004.06.010
Reference
PMID:15552776 (carcinogen)
  Authors
Sasco AJ, Secretan MB, Straif K.
  Title
Tobacco smoking and cancer: a brief review of recent epidemiological evidence.
  Journal
Lung Cancer 45 Suppl 2:S3-9 (2004)
DOI:10.1016/j.lungcan.2004.07.998
Reference
PMID:10764231 (marker)
  Authors
Greenman J, Homer JJ, Stafford ND.
  Title
Markers in cancer of the larynx and pharynx.
  Journal
Clin Otolaryngol Allied Sci 25:9-18 (2000)
DOI:10.1046/j.1365-2273.2000.00339.x
Reference
PMID:15763643 (marker)
  Authors
Almadori G, Bussu F, Cadoni G, Galli J, Paludetti G, Maurizi M.
  Title
Molecular markers in laryngeal squamous cell carcinoma: towards an integrated clinicobiological approach.
  Journal
Eur J Cancer 41:683-93 (2005)
DOI:10.1016/j.ejca.2004.10.031
Reference
PMID:11016683 (marker)
  Authors
Nylander K, Dabelsteen E, Hall PA.
  Title
The p53 molecule and its prognostic role in squamous cell carcinomas of the head and neck.
  Journal
J Oral Pathol Med 29:413-25 (2000)
DOI:10.1034/j.1600-0714.2000.290901.x
Reference
(drug)
  Authors
Papadakis MA and McPhee SJ |(ed)
  Title
Current Medical Diagnosis & Treatment 2015, Fifty-Fourth Edition
  Journal
McGraw Hill Education

» Japanese version

DBGET integrated database retrieval system