KEGG   DISEASE: H00157Help
Entry
H00157                      Disease                                

Name
Hyperlipoproteinemia, type V
Description
Type V hyperlipoproteinemia is an autosomal recessive disorder caused by deficiency of apolipoprotein A-V and characterized by an increase of chylomicrons and VLDL and a decrease of LDL and HDL in the plasma after a fast.
Category
Inherited metabolic disease
BRITE hierarchy
Pathway
PPAR signaling pathway
Gene
APOA5; apolipoprotein A-V [HSA:116519] [KO:K09025]
Marker
chylomicron
VLDL
Drug
Bezafibrate [DR:D01366]
Fenofibrate [DR:D00565]
Other DBs
ICD-10: 
MeSH: 
OMIM: 
Reference
  Authors
Calandra S, Priore Oliva C, Tarugi P, Bertolini S
  Title
APOA5 and triglyceride metabolism, lesson from human APOA5 deficiency.
  Journal
Curr Opin Lipidol 17:122-7 (2006)
Reference
  Authors
Rensen PC, van Dijk KW, Havekes LM
  Title
Apolipoprotein AV: low concentration, high impact.
  Journal
Arterioscler Thromb Vasc Biol 25:2445-7 (2005)

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