KEGG   DISEASE: H00313Help
Entry
H00313                      Disease                                

Name
Multidrug-resistant Pseudomonas aeruginosa infection
Description
Pseudomonas aeruginosa is an opportunistic pathogen that may cause severe invasive diseases in critically ill patients. In the 21st century, when the life expectancy of highly susceptible immunocompromised groups has been extended in most countries, P. aeruginosa plays an increasingly prominent role in hospital infections. This organism shows a remarkable capacity to resist antibiotics, either intrinsically (because of constitutive expression of beta-lactamases and efflux pumps, combined with low permeability of the outer-membrane) or following acquisition of resistance genes (e.g., genes for beta-lactamases, or enzymes inactivating aminoglycosides or modifying their target), over-expression of efflux pumps, decreased expression of porins, or mutations in quinolone targets. These mechanisms mediate the multidrug-resistant (MDR) phenotype in P. aeruginosa.
Category
Infectious disease
Brite
Infectious diseases [BR:br08401]
 Bacterial infections
  Infections caused by other gamma proteobacteria
   H00313  Multidrug-resistant Pseudomonas aeruginosa infection
Human diseases in ICD-10 classification [BR:br08403]
 1. Certain infectious and parasitic diseases (A00-B99)
  A30-A49  Other bacterial diseases
   A49  Bacterial infection of unspecified site
    H00313  Multidrug-resistant Pseudomonas aeruginosa infection
 10. Diseases of the respiratory system (J00-J99)
  J09-J18  Influenza and pneumonia
   J15  Bacterial pneumonia, not elsewhere classified
    H00313  Multidrug-resistant Pseudomonas aeruginosa infection
BRITE hierarchy
Pathway
Beta-Lactam resistance
Pathogen
Pseudomonas aeruginosa [GN:pap pnc prp]
Drug
Colistin [DG:DG00087]
Aztreonam [DG:DG00589]
Meropenem [DG:DG00591]
Polymyxin B [DG:DG00083]
Comment
P. aeruginosa genes containing mutations:
nalC [KO:K18130]
nalD [KO:K18135]
Other DBs
ICD-10: 
MeSH: 
Reference
  Authors
Hirsch EB, Tam VH
  Title
Impact of multidrug-resistant Pseudomonas aeruginosa infection on patient outcomes.
  Journal
Expert Rev Pharmacoecon Outcomes Res 10:441-51 (2010)
Reference
PMID:17266725 (description)
  Authors
Mesaros N, Nordmann P, Plesiat P, Roussel-Delvallez M, Van Eldere J, Glupczynski Y, Van Laethem Y, Jacobs F, Lebecque P, Malfroot A, Tulkens PM, Van Bambeke F
  Title
Pseudomonas aeruginosa: resistance and therapeutic options at the turn of the new millennium.
  Journal
Clin Microbiol Infect 13:560-78 (2007)
Reference
PMID:24409175 (description)
  Authors
Morita Y, Tomida J, Kawamura Y
  Title
Responses of Pseudomonas aeruginosa to antimicrobials.
  Journal
Front Microbiol 4:422 (2014)
Reference
PMID:20107499 (pathogen)
  Authors
Roy PH, Tetu SG, Larouche A, Elbourne L, Tremblay S, Ren Q, Dodson R, Harkins D, Shay R, Watkins K, Mahamoud Y, Paulsen IT
  Title
Complete genome sequence of the multiresistant taxonomic outlier Pseudomonas aeruginosa PA7.
  Journal
PLoS One 5:e8842 (2010)
Reference
PMID:22123763 (pathogen)
  Authors
Miyoshi-Akiyama T, Kuwahara T, Tada T, Kitao T, Kirikae T
  Title
Complete genome sequence of highly multidrug-resistant Pseudomonas aeruginosa NCGM2.S1, a representative strain of a cluster endemic to Japan.
  Journal
J Bacteriol 193:7010 (2011)
Reference
PMID:23908295 (pathogen)
  Authors
Jeukens J, Boyle B, Bianconi I, Kukavica-Ibrulj I, Tummler B, Bragonzi A, Levesque RC
  Title
Complete Genome Sequence of Persistent Cystic Fibrosis Isolate Pseudomonas aeruginosa Strain RP73.
  Journal
Genome Announc 1 (2013)
Reference
PMID:25070493 (drug)
  Authors
Nakamura I, Yamaguchi T, Tsukimori A, Sato A, Fukushima S, Matsumoto T
  Title
New options of antibiotic combination therapy for multidrug-resistant Pseudomonas aeruginosa.
  Journal
Eur J Clin Microbiol Infect Dis 34:83-7 (2015)
Reference
PMID:16641429 (comment)
  Authors
Quale J, Bratu S, Gupta J, Landman D
  Title
Interplay of efflux system, ampC, and oprD expression in carbapenem resistance of Pseudomonas aeruginosa clinical isolates.
  Journal
Antimicrob Agents Chemother 50:1633-41 (2006)

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