KEGG   DISEASE: TuberculosisHelp
Entry
H00342                      Disease                                

Name
Tuberculosis
Description
Tuberculosis is a infectious disease caused by strains of mycobacteria, mainly Mycobacterium tuberculosis, resulting in an estimated two million deaths each year worldwide, more than from any other single bacterial pathogen. Inhalation is the predominant pathway of infection, making pulmonary tuberculosis the most common form of tuberculosis. Tuberculosis may arise either from a recent infection with M. tuberculosis, or from the reactivation of dormant bacilli, years or decades after initial infection. Extrapulmonary tuberculosis mainly results from reactivation of a tuberculous focus after hematogenous dissemination or lymphogenous spread from a primary, usually pulmonary focus.
Category
Infectious disease
Brite
Infectious diseases [BR:br08401]
 Bacterial infections
  Infections caused by actinobacteria
   H00342  Tuberculosis
Human diseases in ICD-10 classification [BR:br08403]
 1. Certain infectious and parasitic diseases (A00-B99)
  A15-A19  Tuberculosis
   A15-A19  Tuberculosis
    H00342  Tuberculosis
BRITE hierarchy
Pathway
Tuberculosis
Gene
IFNGR1 [HSA:3459] [KO:K05132]
IFNGR2 [HSA:3460] [KO:K05133]
HLA-DRB1 [HSA:3123] [KO:K06752]
HLA-DQB1 [HSA:3119] [KO:K06752]
SLC11A1 [HSA:6556] [KO:K12347]
VDR [HSA:7421] [KO:K08539]
MBL [HSA:4153] [KO:K03991]
Pathogen
Mycobacterium tuberculosis [GN:mtu mtc mra mtf mtb mtg mti mte mtl mtj mtuh mtuc mtue]
Drug
Isoniazid [DG:DG00642]
Rifampicin [DG:DG00639]
Pyrazinamide [DR:D00144]
Ethambutol [DG:DG00643]
Other DBs
ICD-10: 
MeSH: 
MedlinePlus: 
Reference
(drug)
  Authors
Papadakis MA and McPhee SJ |(ed)
  Title
Current Medical Diagnosis & Treatment 2007, Forty-Sixth Edition
  Journal
McGraw Hill Education
Reference
PMID:20206579 (gene)
  Authors
Moller M, Hoal EG
  Title
Current findings, challenges and novel approaches in human genetic susceptibility to tuberculosis.
  Journal
Tuberculosis (Edinb) 90:71-83 (2010)
DOI:10.1016/j.tube.2010.02.002
Reference
PMID:16519730 (gene)
  Authors
Fernando SL, Britton WJ
  Title
Genetic susceptibility to mycobacterial disease in humans.
  Journal
Immunol Cell Biol 84:125-37 (2006)
DOI:10.1111/j.1440-1711.2006.01420.x
Reference
PMID:12121000 (gene)
  Authors
Hoal EG
  Title
Human genetic susceptibility to tuberculosis and other mycobacterial diseases.
  Journal
IUBMB Life 53:225-9 (2002)
DOI:10.1080/15216540212644
Reference
PMID:17147011 (description)
  Authors
De Backer AI, Mortele KJ, De Keulenaer BL, Parizel PM
  Title
Tuberculosis: epidemiology, manifestations, and the value of medical imaging in diagnosis.
  Journal
JBR-BTR 89:243-50 (2006)
Reference
PMID:15482144 (description)
  Authors
Smith KC, Armitige L, Wanger A
  Title
A review of tuberculosis: reflections on the past, present and future of a global epidemic disease.
  Journal
Expert Rev Anti Infect Ther 1:483-91 (2003)
DOI:10.1586/14787210.1.3.483
Reference
PMID:21420161 (description)
  Authors
Lawn SD, Zumla AI
  Title
Tuberculosis.
  Journal
Lancet 378:57-72 (2011)
DOI:10.1016/S0140-6736(10)62173-3

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