| Entry |
|
|---|
| Name |
Leprosy;
Hansen disease
|
|---|
| Description |
Leprosy, caused by Mycobacterium leprae, is still one of the main causes of physical disability worldwide. The new case detection rate remains high, with about 250 000 new cases being registered each year. Infection leads to chronic granulomatous inflammation in skin and peripheral nerves and resulting disability brings about social disadvantage for patients and their family members.
|
|---|
| Category |
Infectious disease
 |
|---|
| Pathway |
| Antigen processing and presentation | | Natural killer cell mediated cytotoxicity | | Toll-like receptor signaling pathway | | Cytokine-cytokine receptor interaction | | Protein processing in endoplasmic reticulum |
|
|---|
| Gene |
|
|---|
| Pathogen |
Mycobacterium leprae [GN: mle] (from India)
Mycobacterium leprae [GN: mlb] (from Brazil)
|
|---|
| Marker |
M. leprae phenolic glycolipid-I (PGL-1) (dipstick, ELISA, ML Flow test)
|
|---|
| Drug |
|
|---|
| Other DBs |
OMIM: ICD-10: MedlinePlus: |
|---|
| Reference |
PMID: 21616456 (description, drug, marker) |
|---|
| Authors |
Rodrigues LC, Lockwood DNj |
|---|
| Title |
Leprosy now: epidemiology, progress, challenges, and research gaps. |
|---|
| Journal |
Lancet Infect Dis 11:464-70 (2011) |
|---|
| Reference |
|
|---|
| Authors |
Moschella SL |
|---|
| Title |
An update on the diagnosis and treatment of leprosy. |
|---|
| Journal |
J Am Acad Dermatol 51:417-26 (2004) |
|---|
| Reference |
|
|---|
| Authors |
Cardoso CC, Pereira AC, de Sales Marques C, Moraes MO |
|---|
| Title |
Leprosy susceptibility: genetic variations regulate innate and adaptive immunity, and disease outcome. |
|---|
| Journal |
Future Microbiol 6:533-49 (2011) |
|---|
| Reference |
|
|---|
| Authors |
Geluk A, Ottenhoff TH |
|---|
| Title |
HLA and leprosy in the pre and postgenomic eras. |
|---|
| Journal |
Hum Immunol 67:439-45 (2006) |
|---|
| Reference |
|
|---|
| Authors |
Johnson CM, Lyle EA, Omueti KO, Stepensky VA, Yegin O, Alpsoy E, Hamann L, Schumann RR, Tapping RI |
|---|
| Title |
Cutting edge: A common polymorphism impairs cell surface trafficking and functional responses of TLR1 but protects against leprosy. |
|---|
| Journal |
J Immunol 178:7520-4 (2007) |
|---|
| Reference |
|
|---|
| Authors |
Malhotra D, Relhan V, Reddy BS, Bamezai R |
|---|
| Title |
TLR2 Arg677Trp polymorphism in leprosy: revisited. |
|---|
| Journal |
Hum Genet 116:413-5 (2005) |
|---|
| Reference |
|
|---|
| Authors |
Alcais A, Alter A, Antoni G, Orlova M, Nguyen VT, Singh M, Vanderborght PR, Katoch K, Mira MT, Vu HT, Ngyuen TH, Nguyen NB, Moraes M, Mehra N, Schurr E, Abel L |
|---|
| Title |
Stepwise replication identifies a low-producing lymphotoxin-alpha allele as a major risk factor for early-onset leprosy. |
|---|
| Journal |
Nat Genet 39:517-22 (2007) |
|---|
| Reference |
|
|---|
| Authors |
Mira MT, Alcais A, Nguyen VT, Moraes MO, Di Flumeri C, Vu HT, Mai CP, Nguyen TH, Nguyen NB, Pham XK, Sarno EN, Alter A, Montpetit A, Moraes ME, Moraes JR, Dore C, Gallant CJ, Lepage P, Verner A, Van De Vosse E, Hudson TJ, Abel L, Schurr E |
|---|
| Title |
Susceptibility to leprosy is associated with PARK2 and PACRG. |
|---|
| Journal |
Nature 427:636-40 (2004) |
|---|
