KEGG   DISEASE: H00363Help
Entry
H00363                      Disease                                

Name
Candidiasis
Description
Candidiasis is a fungal infection with Candida species, predominantly with Candida albicans. Invasive candidiasis is a major cause of morbidity and mortality in the intensive care unit (ICU) setting, causing bloodstream infections. Recently, various non-C. albicans species have emerged as infecting agents. In patients with impaired IL-17 immunity, recurrent or persistent infections are observed (chronic mucocutaneous candidiasis disease).
Category
Infectious disease
BRITE hierarchy
Gene
IL17RA [HSA:23765] [KO:K05164]
IL17F [HSA:112744] [KO:K05494]
STAT1 [HSA:6772] [KO:K11220]
Pathogen
Candida albicans [GN:cal]
Candida dubliniensis [GN:cdu]
Candida tropicalis [GN:ctp]
Candida glabrata [GN:cgr]
Drug
Clotrimazole [DR:D00282]
Fluconazole [DR:D00322]
Isoconazole [DR:D01480]
Itraconazole [DR:D00350]
Ketoconazole [DR:D00351]
Miconazole [DR:D00416]
Nystatin [DR:D00202]
Other DBs
ICD-10: 
MeSH: 
Reference
  Authors
Papadakis MA, Tierney LM (ed).
  Title
[Current Medical Diagnosis & Treatment 2004, Forty-Third Edition] (In Japanese)
  Journal
Nikkei Business Publications, Inc. (2004)
Reference
PMID:21486733 (description)
  Authors
Rodloff C, Koch D, Schaumann R
  Title
Epidemiology and antifungal resistance in invasive candidiasis.
  Journal
Eur J Med Res 16:187-95 (2011)
Reference
PMID:18279532 (description)
  Authors
Mean M, Marchetti O, Calandra T
  Title
Bench-to-bedside review: Candida infections in the intensive care unit.
  Journal
Crit Care 12:204 (2008)
Reference
PMID:21350122 (gene)
  Authors
Puel A, Cypowyj S, Bustamante J, Wright JF, Liu L, Lim HK, Migaud M, Israel L, Chrabieh M, Audry M, Gumbleton M, Toulon A, Bodemer C, El-Baghdadi J, Whitters M, Paradis T, Brooks J, Collins M, Wolfman NM, Al-Muhsen S, Galicchio M, Abel L, Picard C, Casanova JL
  Title
Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17  immunity.
  Journal
Science 332:65-8 (2011)
Reference
PMID:21727188 (gene)
  Authors
Liu L, Okada S, Kong XF, Kreins AY, Cypowyj S, Abhyankar A, Toubiana J, Itan Y, Audry M, Nitschke P, Masson C, Toth B, Flatot J, Migaud M, Chrabieh M, Kochetkov T, Bolze A, Borghesi A, Toulon A, Hiller J, Eyerich S, Eyerich K, Gulacsy V, Chernyshova L, Chernyshov V, Bondarenko A, Maria Cortes Grimaldo R, Blancas-Galicia L, Madrigal Beas IM, Roesler J, Magdorf K, Engelhard D, Thumerelle C, Burgel PR, Hoernes M, Drexel B, Seger R, Kusuma T, Jansson AF, Sawalle-Belohradsky J, Belohradsky B, Jouanguy E, Bustamante J, Bue M, Karin N, Wildbaum G, Bodemer C, Lortholary O, Fischer A, Blanche S, Al-Muhsen S, Reichenbach J, Kobayashi M, Rosales FE, Lozano CT, Kilic SS, Oleastro M, Etzioni A, Traidl-Hoffmann C, Renner ED, Abel L, Picard C, Marodi L, Boisson-Dupuis S, Puel A, Casanova JL
  Title
Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis.
  Journal
J Exp Med 208:1635-48 (2011)

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