| Entry |
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| Name |
Brunner syndrome;
MAOA deficiency
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| Description |
Brunner syndrome is a form of X-linked non-dysmorphic mild mental retardation. It is caused by a monoamine oxidase A (MAOA) deficiency, which leads to an excess of monoamines in the brain, such as serotonin, dopamine, and epinephrine.
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| Category |
Inherited metabolic disease; mental retardation
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| Pathway |
| Histidine metabolism | | Tyrosine metabolism | | Tryptophan metabolism | | Dopaminergic synapse |
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| Gene |
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| Marker |
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| Other DBs |
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| Reference |
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| Authors |
Brunner HG, Nelen M, Breakefield XO, Ropers HH, van Oost BA |
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| Title |
Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. |
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| Journal |
Science 262:578-80 (1993) |
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| Reference |
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| Authors |
Craig IW |
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| Title |
The importance of stress and genetic variation in human aggression. |
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| Journal |
Bioessays 29:227-36 (2007) |
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| Reference |
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| Authors |
Ropers HH, Hamel BC |
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| Title |
X-linked mental retardation. |
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| Journal |
Nat Rev Genet 6:46-57 (2005) |
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| Reference |
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| Authors |
Brunner HG |
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| Title |
MAOA deficiency and abnormal behaviour: perspectives on an association. |
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| Journal |
Ciba Found Symp 194:155-64; discussion 164-7 (1996) |
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