KEGG   DISEASE: H00681Help
Entry
H00681                      Disease                                

Name
Acne inversa;
Hidradenitis supprativa
Description
Acne inversa (AI), also known as hidradenitis suppurativa, is a chronic inflammatory disorder of hair follicles involving the apocrine gland-bearing areas of the body. Its characteristic features include recurrent formation of painful skin abscesses, fistulating sinuses, and disfiguring scars.
Category
Skin and connective tissue disease
Brite
Human diseases [BR:br08402]
 Skin diseases
  Skin and soft tissue diseases
   H00681  Acne inversa
Human diseases in ICD-10 classification [BR:br08403]
 12. Diseases of the skin and subcutaneous tissue (L00-L99)
  L60-L75  Disorders of skin appendages
   L73  Other follicular disorders
    H00681  Acne inversa
BRITE hierarchy
Pathway
Wnt signaling pathway
Notch signaling pathway  
Neurotrophin signaling pathway
Gene
PSENEN [HSA:55851] [KO:K06170]
PSEN1 [HSA:5663] [KO:K04505]
NCSTN [HSA:23385] [KO:K06171]
Env factor
Smoking
Staphylococci infection
Androgen levels
Other DBs
ICD-10: 
MeSH: 
OMIM: 
Reference
PMID:21192260 (description, env_factor, drug)
  Authors
Yazdanyar S, Jemec GB
  Title
Hidradenitis suppurativa: a review of cause and treatment.
  Journal
Curr Opin Infect Dis 24:118-23 (2011)
Reference
PMID:17958790 (drug)
  Authors
Lam J, Krakowski AC, Friedlander SF
  Title
Hidradenitis suppurativa (acne inversa): management of a recalcitrant disease.
  Journal
Pediatr Dermatol 24:465-73 (2007)
Reference
PMID:15264991 (drug)
  Authors
Jemec GB
  Title
Medical treatment of hidradenitis suppurativa.
  Journal
Expert Opin Pharmacother 5:1767-70 (2004)
Reference
PMID:21495993 (gene)
  Authors
Li CR, Jiang MJ, Shen DB, Xu HX, Wang HS, Yao X, Zhang Y, Zhou WQ, Wang B
  Title
Two novel mutations of the nicastrin gene in Chinese patients with acne inversa.
  Journal
Br J Dermatol 165:415-8 (2011)
Reference
PMID:20929727 (gene)
  Authors
Wang B, Yang W, Wen W, Sun J, Su B, Liu B, Ma D, Lv D, Wen Y, Qu T, Chen M, Sun M, Shen Y, Zhang X
  Title
Gamma-secretase gene mutations in familial acne inversa.
  Journal
Science 330:1065 (2010)

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