KEGG   DISEASE: H00681Help
Entry
H00681                      Disease                                

Name
Acne inversa;
Hidradenitis supprativa
Description
Acne inversa (AI), also known as hidradenitis suppurativa, is a chronic inflammatory disorder of hair follicles involving the apocrine gland-bearing areas of the body. Its characteristic features include recurrent formation of painful skin abscesses, fistulating sinuses, and disfiguring scars.
Category
Skin and connective tissue disease
BRITE hierarchy
Pathway
Wnt signaling pathway
Notch signaling pathway  
Neurotrophin signaling pathway
Gene
PSENEN [HSA:55851] [KO:K06170]
PSEN1 [HSA:5663] [KO:K04505]
NCSTN [HSA:23385] [KO:K06171]
Env factor
Smoking
Staphylococci infection
Androgen levels
Other DBs
ICD-10: 
MeSH: 
OMIM: 
Reference
PMID:21192260 (description, env_factor, drug)
  Authors
Yazdanyar S, Jemec GB
  Title
Hidradenitis suppurativa: a review of cause and treatment.
  Journal
Curr Opin Infect Dis 24:118-23 (2011)
Reference
PMID:17958790 (drug)
  Authors
Lam J, Krakowski AC, Friedlander SF
  Title
Hidradenitis suppurativa (acne inversa): management of a recalcitrant disease.
  Journal
Pediatr Dermatol 24:465-73 (2007)
Reference
PMID:15264991 (drug)
  Authors
Jemec GB
  Title
Medical treatment of hidradenitis suppurativa.
  Journal
Expert Opin Pharmacother 5:1767-70 (2004)
Reference
PMID:21495993 (gene)
  Authors
Li CR, Jiang MJ, Shen DB, Xu HX, Wang HS, Yao X, Zhang Y, Zhou WQ, Wang B
  Title
Two novel mutations of the nicastrin gene in Chinese patients with acne inversa.
  Journal
Br J Dermatol 165:415-8 (2011)
Reference
PMID:20929727 (gene)
  Authors
Wang B, Yang W, Wen W, Sun J, Su B, Liu B, Ma D, Lv D, Wen Y, Qu T, Chen M, Sun M, Shen Y, Zhang X
  Title
Gamma-secretase gene mutations in familial acne inversa.
  Journal
Science 330:1065 (2010)

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