KEGG   DISEASE: H00689Help
Entry
H00689                      Disease                                

Name
Delayed sleep phase syndrome
Description
Delayed sleep phase disorder is characterized by a 3 to 6-hour delayed sleep schedule relative to the desired. The single nucleotide polymorphism (Ala129Thr) in Arylalkylamine N-acetyltransferase (AANAT), a rate-limiting enzyme in melatonin synthesis, has been identified in patients with delayed sleep phase disorder.
Category
Sleep disorder
BRITE hierarchy
Pathway
Tryptophan metabolism
Metabolic pathways
Gene
AANAT (polymorphysm) [HSA:15] [KO:K00669]
Other DBs
MeSH: 
OMIM: 
Reference
PMID:21929966 (descritpion)
  Authors
Barion A
  Title
Circadian rhythm sleep disorders.
  Journal
Dis Mon 57:423-37 (2011)
Reference
PMID:18845459 (descritpion)
  Authors
Bjorvatn B, Pallesen S
  Title
A practical approach to circadian rhythm sleep disorders.
  Journal
Sleep Med Rev 13:47-60 (2009)
Reference
PMID:12736803 (gene)
  Authors
Hohjoh H, Takasu M, Shishikura K, Takahashi Y, Honda Y, Tokunaga K
  Title
Significant association of the arylalkylamine N-acetyltransferase ( AA-NAT) gene  with delayed sleep phase syndrome.
  Journal
Neurogenetics 4:151-3 (2003)

» Japanese version

DBGET integrated database retrieval system