| Entry |
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| Name |
Delayed sleep phase syndrome
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| Description |
Delayed sleep phase disorder is characterized by a 3 to 6-hour delayed sleep schedule relative to the desired. The single nucleotide polymorphism (Ala129Thr) in Arylalkylamine N-acetyltransferase (AANAT), a rate-limiting enzyme in melatonin synthesis, has been identified in patients with delayed sleep phase disorder.
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| Category |
Sleep disorders
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| Pathway |
| Tryptophan metabolism | | Metabolic pathways |
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| Gene |
AANAT (polymorphysm) [HSA: 15] [KO: K00669]
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| Other DBs |
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| Reference |
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| Authors |
Barion A |
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| Title |
Circadian rhythm sleep disorders. |
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| Journal |
Dis Mon 57:423-37 (2011) |
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| Reference |
|
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| Authors |
Bjorvatn B, Pallesen S |
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| Title |
A practical approach to circadian rhythm sleep disorders. |
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| Journal |
Sleep Med Rev 13:47-60 (2009) |
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| Reference |
|
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| Authors |
Hohjoh H, Takasu M, Shishikura K, Takahashi Y, Honda Y, Tokunaga K |
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| Title |
Significant association of the arylalkylamine N-acetyltransferase ( AA-NAT) gene with delayed sleep phase syndrome. |
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| Journal |
Neurogenetics 4:151-3 (2003) |
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