KEGG   DISEASE: H00721Help
Entry
H00721                      Disease                                

Name
Pyogenic bacterial infections, recurrent, due to MYD88 deficiency
Description
Autosomal recessive MyD88 deficiency predisposes affected patients to recurrent pyogenic bacterial infections, including invasive pneumococcal disease. The patients are resistant to other microbes.
Category
Immune system disease
BRITE hierarchy
Pathway
Apoptosis
Toll-like receptor signaling pathway
Gene
MYD88 [HSA:4615] [KO:K04729]
Other DBs
MeSH: 
OMIM: 
Reference
PMID:18669862 (description, gene)
  Authors
von Bernuth H, Picard C, Jin Z, Pankla R, Xiao H, Ku CL, Chrabieh M, Mustapha IB, Ghandil P, Camcioglu Y, Vasconcelos J, Sirvent N, Guedes M, Vitor AB, Herrero-Mata MJ, Arostegui JI, Rodrigo C, Alsina L, Ruiz-Ortiz E, Juan M, Fortuny C, Yague J, Anton J, Pascal M, Chang HH, Janniere L, Rose Y, Garty BZ, Chapel H, Issekutz A, Marodi L, Rodriguez-Gallego C, Banchereau J, Abel L, Li X, Chaussabel D, Puel A, Casanova JL
  Title
Pyogenic bacterial infections in humans with MyD88 deficiency.
  Journal
Science 321:691-6 (2008)
Reference
PMID:21734245 (description, gene)
  Authors
Picard C, Casanova JL, Puel A
  Title
Infectious diseases in patients with IRAK-4, MyD88, NEMO, or IkappaBalpha deficiency.
  Journal
Clin Microbiol Rev 24:490-7 (2011)
Reference
PMID:20236864 (description, gene)
  Authors
Bousfiha A, Picard C, Boisson-Dupuis S, Zhang SY, Bustamante J, Puel A, Jouanguy E, Ailal F, El-Baghdadi J, Abel L, Casanova JL
  Title
Primary immunodeficiencies of protective immunity to primary infections.
  Journal
Clin Immunol 135:204-9 (2010)

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