KEGG   DISEASE: Atrial fibrillationHelp
H00731                      Disease                                

Atrial fibrillation
Atrial fibrillation (AF, ATFB) is the most common cardiac arrhythmia and is regarded generally as a sporadic, acquired disorder. Nevertheless, recent growing evidence points to an important heritable basis for AF. By linkage analysis, several loci have been mapped for monogenetic AF. Some of these loci encode for subunits of potassium channels.
Cardiovascular disease
Human diseases [BR:br08402]
 Cardiovascular diseases
  Cardiac diseases
   H00731  Atrial fibrillation
Human diseases in ICD-10 classification [BR:br08403]
 9. Diseases of the circulatory system (I00-I99)
  I30-I52  Other forms of heart disease
   I48  Atrial fibrillation and flutter
    H00731  Atrial fibrillation
BRITE hierarchy
Vascular smooth muscle contraction
Adrenergic signaling in cardiomyocytes
(ATFB3) KCNQ1 [HSA:3784] [KO:K04926]
(ATFB4) KCNE2 [HSA:9992] [KO:K04896]
(ATFB6) NPPA [HSA:4878] [KO:K12334]
(ATFB7) KCNA5 [HSA:3741] [KO:K04878]
(ATFB9) KCNJ2 [HSA:3759] [KO:K04996]
(ATFB10) SCN5A [HSA:6331] [KO:K04838]
(ATFB11) GJA5 [HSA:2702] [KO:K07614]
(ATFB12) ABCC9 [HSA:10060] [KO:K05033]
(ATFB13) SCN1B [HSA:6324] [KO:K04845]
(ATFB14) SCN2B [HSA:6327] [KO:K04846]
(ATFB15) NUP155 [HSA:9631] [KO:K14312]
(ATFB16) SCN3B [HSA:55800] [KO:K04847]
(ATFB17) SCN4B [HSA:6330] [KO:K04848]
(ATFB18) MYL4 [HSA:4635] [KO:K12750]
Other DBs
Tsai CT, Lai LP, Hwang JJ, Lin JL, Chiang FT
Molecular genetics of atrial fibrillation.
J Am Coll Cardiol 52:241-50 (2008)
Otway R, Vandenberg JI, Fatkin D
Atrial fibrillation--a new cardiac channelopathy.
Heart Lung Circ 16:356-60 (2007)
PMID:19808477 (gene)
Watanabe H, Darbar D, Kaiser DW, Jiramongkolchai K, Chopra S, Donahue BS, Kannankeril PJ, Roden DM
Mutations in sodium channel beta1- and beta2-subunits associated with atrial fibrillation.
Circ Arrhythm Electrophysiol 2:268-75 (2009)
PMID:19070573 (gene)
Zhang X, Chen S, Yoo S, Chakrabarti S, Zhang T, Ke T, Oberti C, Yong SL, Fang F, Li L, de la Fuente R, Wang L, Chen Q, Wang QK
Mutation in nuclear pore component NUP155 leads to atrial fibrillation and early  sudden cardiac death.
Cell 135:1017-27 (2008)
PMID:21051419 (gene)
Olesen MS, Jespersen T, Nielsen JB, Liang B, Moller DV, Hedley P, Christiansen M, Varro A, Olesen SP, Haunso S, Schmitt N, Svendsen JH
Mutations in sodium channel beta-subunit SCN3B are associated with early-onset lone atrial fibrillation.
Cardiovasc Res 89:786-93 (2011)
PMID:27066836 (gene)
Orr N, Arnaout R, Gula LJ, Spears DA, Leong-Sit P, Li Q, Tarhuni W, Reischauer S, Chauhan VS, Borkovich M, Uppal S, Adler A, Coughlin SR, Stainier DY, Gollob MH
A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial  atrial fibrillation.
Nat Commun 7:11303 (2016)

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