KEGG   DISEASE: H00731Help
Entry
H00731                      Disease                                

Name
Atrial fibrillation
Description
Atrial fibrillation (AF, ATFB) is the most common cardiac arrhythmia and is regarded generally as a sporadic, acquired disorder. Nevertheless, recent growing evidence points to an important heritable basis for AF. By linkage analysis, several loci have been mapped for monogenetic AF. Some of these loci encode for subunits of potassium channels.
Category
Cardiovascular disease
BRITE hierarchy
Pathway
Vascular smooth muscle contraction
Gene
(ATFB3) KCNQ1 [HSA:3784] [KO:K04926]
(ATFB4) KCNE2 [HSA:9992] [KO:K04896]
(ATFB6) NPPA [HSA:4878] [KO:K12334]
(ATFB7) KCNA5 [HSA:3741] [KO:K04878]
(ATFB9) KCNJ2 [HSA:3759] [KO:K04996]
(ATFB10) SCN5A [HSA:6331] [KO:K04838]
(ATFB11) GJA5 [HSA:2702] [KO:K07614]
(ATFB12) ABCC9 [HSA:10060] [KO:K05033]
Other DBs
Reference
  Authors
Tsai CT, Lai LP, Hwang JJ, Lin JL, Chiang FT
  Title
Molecular genetics of atrial fibrillation.
  Journal
J Am Coll Cardiol 52:241-50 (2008)
Reference
  Authors
Otway R, Vandenberg JI, Fatkin D
  Title
Atrial fibrillation--a new cardiac channelopathy.
  Journal
Heart Lung Circ 16:356-60 (2007)

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