KEGG   DISEASE: Atrial fibrillationHelp
Entry
H00731                      Disease                                

Name
Atrial fibrillation
Description
Atrial fibrillation (AF, ATFB) is the most common cardiac arrhythmia and is regarded generally as a sporadic, acquired disorder. Nevertheless, recent growing evidence points to an important heritable basis for AF. By linkage analysis, several loci have been mapped for monogenetic AF. Some of these loci encode for subunits of potassium channels.
Category
Cardiovascular disease
Brite
Human diseases [BR:br08402]
 Cardiovascular diseases
  Cardiac diseases
   H00731  Atrial fibrillation
Human diseases in ICD-10 classification [BR:br08403]
 9. Diseases of the circulatory system (I00-I99)
  I30-I52  Other forms of heart disease
   I48  Atrial fibrillation and flutter
    H00731  Atrial fibrillation
BRITE hierarchy
Pathway
Vascular smooth muscle contraction
Adrenergic signaling in cardiomyocytes
Gene
(ATFB3) KCNQ1 [HSA:3784] [KO:K04926]
(ATFB4) KCNE2 [HSA:9992] [KO:K04896]
(ATFB6) NPPA [HSA:4878] [KO:K12334]
(ATFB7) KCNA5 [HSA:3741] [KO:K04878]
(ATFB9) KCNJ2 [HSA:3759] [KO:K04996]
(ATFB10) SCN5A [HSA:6331] [KO:K04838]
(ATFB11) GJA5 [HSA:2702] [KO:K07614]
(ATFB12) ABCC9 [HSA:10060] [KO:K05033]
(ATFB13) SCN1B [HSA:6324] [KO:K04845]
(ATFB14) SCN2B [HSA:6327] [KO:K04846]
(ATFB15) NUP155 [HSA:9631] [KO:K14312]
(ATFB16) SCN3B [HSA:55800] [KO:K04847]
(ATFB17) SCN4B [HSA:6330] [KO:K04848]
(ATFB18) MYL4 [HSA:4635] [KO:K12750]
Other DBs
Reference
  Authors
Tsai CT, Lai LP, Hwang JJ, Lin JL, Chiang FT
  Title
Molecular genetics of atrial fibrillation.
  Journal
J Am Coll Cardiol 52:241-50 (2008)
DOI:10.1016/j.jacc.2008.02.072
Reference
  Authors
Otway R, Vandenberg JI, Fatkin D
  Title
Atrial fibrillation--a new cardiac channelopathy.
  Journal
Heart Lung Circ 16:356-60 (2007)
DOI:10.1016/j.hlc.2007.07.003
Reference
PMID:19808477 (gene)
  Authors
Watanabe H, Darbar D, Kaiser DW, Jiramongkolchai K, Chopra S, Donahue BS, Kannankeril PJ, Roden DM
  Title
Mutations in sodium channel beta1- and beta2-subunits associated with atrial fibrillation.
  Journal
Circ Arrhythm Electrophysiol 2:268-75 (2009)
DOI:10.1161/CIRCEP.108.779181
Reference
PMID:19070573 (gene)
  Authors
Zhang X, Chen S, Yoo S, Chakrabarti S, Zhang T, Ke T, Oberti C, Yong SL, Fang F, Li L, de la Fuente R, Wang L, Chen Q, Wang QK
  Title
Mutation in nuclear pore component NUP155 leads to atrial fibrillation and early sudden cardiac death.
  Journal
Cell 135:1017-27 (2008)
DOI:10.1016/j.cell.2008.10.022
Reference
PMID:21051419 (gene)
  Authors
Olesen MS, Jespersen T, Nielsen JB, Liang B, Moller DV, Hedley P, Christiansen M, Varro A, Olesen SP, Haunso S, Schmitt N, Svendsen JH
  Title
Mutations in sodium channel beta-subunit SCN3B are associated with early-onset lone atrial fibrillation.
  Journal
Cardiovasc Res 89:786-93 (2011)
DOI:10.1093/cvr/cvq348
Reference
PMID:27066836 (gene)
  Authors
Orr N, Arnaout R, Gula LJ, Spears DA, Leong-Sit P, Li Q, Tarhuni W, Reischauer S, Chauhan VS, Borkovich M, Uppal S, Adler A, Coughlin SR, Stainier DY, Gollob MH
  Title
A mutation in the atrial-specific myosin light chain gene (MYL4) causes familial atrial fibrillation.
  Journal
Nat Commun 7:11303 (2016)
DOI:10.1038/ncomms11303

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