Tumor necrosis factor receptor-associated periodic syndrome (TRAPS);
Familial periodic fever

The tumor necrosis factor receptor-associated periodic sydrome (TRAPS) is a multisystem auto-inflammatory disorder that is inherited in an autosomal dominant manner. It is characterized by recurrent febrile attacks and localized inflammation in the absence of autoantibodies. Recurrent fever, abdominal pain, myalgia, and arthralgia are the most common manifestations of TRAPS.

Autoimmune disease

TNFRSF1A [HSA:7132] [KO:K03158]

Etanercept [DR:D00742]

PMID:12352631 (description, gene)

Hull KM, Drewe E, Aksentijevich I, Singh HK, Wong K, McDermott EM, Dean J, Powell RJ, Kastner DL

The TNF receptor-associated periodic syndrome (TRAPS): emerging concepts of an autoinflammatory disorder.

Medicine (Baltimore) 81:349-68 (2002)

PMID:16447098 (description, gene)

Rezaei N

TNF-receptor-associated periodic syndrome (TRAPS): an autosomal dominant multisystem disorder.

Clin Rheumatol 25:773-7 (2006)

PMID:18408954 (description, gene)

Jesus AA, Oliveira JB, Aksentijevich I, Fujihira E, Carneiro-Sampaio MM, Duarte AJ, Silva CA

TNF receptor-associated periodic syndrome (TRAPS): description of a novel TNFRSF1A mutation and response to etanercept.

Eur J Pediatr 167:1421-5 (2008)