KEGG   DISEASE: H00912Help
Entry
H00912                      Disease                                

Name
Tumor necrosis factor receptor-associated periodic syndrome (TRAPS);
Familial periodic fever
Description
The tumor necrosis factor receptor-associated periodic sydrome (TRAPS) is a multisystem auto-inflammatory disorder that is inherited in an autosomal dominant manner. It is characterized by recurrent febrile attacks and localized inflammation in the absence of autoantibodies. Recurrent fever, abdominal pain, myalgia, and arthralgia are the most common manifestations of TRAPS.
Category
Autoimmune disease
BRITE hierarchy
Pathway
MAPK signaling pathway
Cytokine-cytokine receptor interaction  
Apoptosis
Gene
TNFRSF1A [HSA:7132] [KO:K03158]
Drug
Etanercept [DR:D00742]
Other DBs
ICD-10: 
MeSH: 
OMIM: 
Reference
PMID:12352631 (description, gene)
  Authors
Hull KM, Drewe E, Aksentijevich I, Singh HK, Wong K, McDermott EM, Dean J, Powell RJ, Kastner DL
  Title
The TNF receptor-associated periodic syndrome (TRAPS): emerging concepts of an autoinflammatory disorder.
  Journal
Medicine (Baltimore) 81:349-68 (2002)
Reference
PMID:16447098 (description, gene)
  Authors
Rezaei N
  Title
TNF-receptor-associated periodic syndrome (TRAPS): an autosomal dominant multisystem disorder.
  Journal
Clin Rheumatol 25:773-7 (2006)
Reference
PMID:18408954 (description, gene)
  Authors
Jesus AA, Oliveira JB, Aksentijevich I, Fujihira E, Carneiro-Sampaio MM, Duarte AJ, Silva CA
  Title
TNF receptor-associated periodic syndrome (TRAPS): description of a novel TNFRSF1A mutation and response to etanercept.
  Journal
Eur J Pediatr 167:1421-5 (2008)

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