KEGG   DISEASE: Precocious pubertyHelp
H00937                      Disease                                

Precocious puberty, including:
Central precocious puberty (CEPREPU);
Familial male precocious puberty (FMPP)
Precocious puberty has been classically defined as the onset of secondary sexual characteristics in girls younger than 8 years old and in boys younger than 9 and a half years old. Central precocious puberty (CEPREPU) refers to a gonadotropin-dependent type which results from premature activation of the hypothalamic-pituitary-gonadal axis (HPG). CEPREPU is much more frequent in girls than in boys (up to 20:1 ratio). Recently, kisspeptin receptor (KISS1R) and its ligand, kisspeptin, were revealed as major gatekeepers of puberty onset. Mutations of the KISS1R gene were described in patients with impaired pubertal development. On the other hand, it has been reported that heterozygous mutations of the LHCGR gene cause gonadotropin-independent precocious puberty in males, but have no detectable effects on prepubertal or postpubertal females.
Endocrine disease
Human diseases [BR:br08402]
 Endocrine and metabolic diseases
  Hypothalamus and pituitary gland diseases
   H00937  Precocious puberty
Human diseases in ICD-10 classification [BR:br08403]
 4. Endocrine, nutritional and metabolic diseases (E00-E90)
  E20-E35  Disorders of other endocrine glands
   E30  Disorders of puberty, not elsewhere classified
    H00937  Precocious puberty
BRITE hierarchy
Calcium signaling pathway
Neuroactive ligand-receptor interaction
GnRH signaling pathway
(CEPREPU) KISS1R [HSA:84634] [KO:K08374]
(FMPP) LHCGR [HSA:3973] [KO:K04248]
Leuprorelin [DR:D00989]
Nafarelin [DR:D00990]
Buserelin [DR:D01831]
Other DBs
Teles MG, Silveira LF, Tusset C, Latronico AC
New genetic factors implicated in human GnRH-dependent precocious puberty: the role of kisspeptin system.
Mol Cell Endocrinol 346:84-90 (2011)
Segaloff DL
Diseases associated with mutations of the human lutropin receptor.
Prog Mol Biol Transl Sci 89:97-114 (2009)
PMID:18478155 (drug)
Bertelloni S, Mul D
Treatment of central precocious puberty by GnRH analogs: long-term outcome in men.
Asian J Androl 10:525-34 (2008)

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