KEGG   DISEASE: H00967Help
Entry
H00967                      Disease                                

Name
Adiponectin deficiency
Description
Adiponectin is a major adipocyte-derived protein with insulin-sensitizing, anti-inflammatory and anti-atherogenic properties. Adiponectin deficiency related to several obesity related malignancies including colorectal cancer.
Category
Metabolic disease
BRITE hierarchy
Pathway
PPAR signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Gene
ADIPOQ [HSA:9370] [KO:K07296]
Other DBs
MeSH: 
OMIM: 
Reference
  Authors
Saxena A, Chumanevich A, Fletcher E, Larsen B, Lattwein K, Kaur K, Fayad R
  Title
Adiponectin deficiency: Role in chronic inflammation induced colon cancer.
  Journal
Biochim Biophys Acta (2011)
Reference
  Authors
Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T
  Title
Cloning of adiponectin receptors that mediate antidiabetic metabolic effects.
  Journal
Nature 423:762-9 (2003)
Reference
  Authors
Kubota N, Terauchi Y, Yamauchi T, Kubota T, Moroi M, Matsui J, Eto K, Yamashita T, Kamon J, Satoh H, Yano W, Froguel P, Nagai R, Kimura S, Kadowaki T, Noda T
  Title
Disruption of adiponectin causes insulin resistance and neointimal formation.
  Journal
J Biol Chem 277:25863-6 (2002)
Reference
  Authors
Yamauchi T, Kamon J, Waki H, Imai Y, Shimozawa N, Hioki K, Uchida S, Ito Y, Takakuwa K, Matsui J, Takata M, Eto K, Terauchi Y, Komeda K, Tsunoda M, Murakami K, Ohnishi Y, Naitoh T, Yamamura K, Ueyama Y, Froguel P, Kimura S, Nagai R, Kadowaki T
  Title
Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis.
  Journal
J Biol Chem 278:2461-8 (2003)

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