KEGG   DISEASE: H01016Help
Entry
H01016                      Disease                                

Name
Primary bile acid malabsorption
Description
This disease occurs when there is impaired absorption of bile acids in the terminal ileum. In patients with terminal ileal resection or impaired terminal ileal function, bile acids are not reabsorbed and excess colonic bile acids cause diarrhea. Excess colonic bile acids can be seen in patients with a histological normal terminal ileum and this has been called primary bile acid malabsorption.
Category
Gastrointestinal disease
BRITE hierarchy
Pathway
Bile secretion
Gene
SLC10A2 (polymorphism) [HSA:6555] [KO:K14342]
Comment
FGF19, produced in the ileum in response to bile acid absorption, regulates hepatic bile acid synthesis.
Other DBs
MeSH: 
OMIM: 
Reference
PMID:21805078 (description, gene)
  Authors
Johnston I, Nolan J, Pattni SS, Walters JR
  Title
New insights into bile acid malabsorption.
  Journal
Curr Gastroenterol Rep 13:418-25 (2011)
Reference
PMID:19426836 (description)
  Authors
Walters JR, Tasleem AM, Omer OS, Brydon WG, Dew T, le Roux CW
  Title
A new mechanism for bile acid diarrhea: defective feedback inhibition of bile acid biosynthesis.
  Journal
Clin Gastroenterol Hepatol 7:1189-94 (2009)

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