KEGG   DISEASE: Acute alcohol sensitivity
Entry
H01071                      Disease                                
Name
Acute alcohol sensitivity
Description
Aldehyde dehydrogenases (ALDHs) are important enzymes that eliminate toxic aldehydes by catalysing their oxidation to non-reactive acids. It is reported that a deficiency in the ALDH2 is associated with the alcohol flush reaction. More than 40% of the East Asians population carries a common ALDH2 mutant allele, which results in a dramatic reduction in the enzymatic activity when compared with the wild-type allele.
Category
Inherited metabolic disorder
Brite
Human diseases in ICD-11 classification [BR:br08403]
 06 Mental, behavioural or neurodevelopmental disorders
  Disorders due to substance use or addictive behaviours
   Disorders due to substance use
    6C40  Disorders due to use of alcohol
     H01071  Acute alcohol sensitivity
Pathway
hsa00010  Glycolysis / Gluconeogenesis
hsa00620  Pyruvate metabolism
Gene
ALDH2 [HSA:217] [KO:K00128]
Other DBs
ICD-11: 6C40.3
OMIM: 610251
Reference
PMID:16792555
  Authors
Dickson PA, James MR, Heath AC, Montgomery GW, Martin NG, Whitfield JB, Birley AJ
  Title
Effects of variation at the ALDH2 locus on alcohol metabolism, sensitivity, consumption, and dependence in Europeans.
  Journal
Alcohol Clin Exp Res 30:1093-100 (2006)
DOI:10.1111/j.1530-0277.2006.00128.x
Reference
PMID:20558439
  Authors
Chen CH, Sun L, Mochly-Rosen D
  Title
Mitochondrial aldehyde dehydrogenase and cardiac diseases.
  Journal
Cardiovasc Res 88:51-7 (2010)
DOI:10.1093/cvr/cvq192

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Disease (1)   
   OMIM (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
Literature (2)   
   PubMed (2)   
All databases (5)   

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