KEGG   DISEASE: Acute alcohol sensitivityHelp
Entry
H01071                      Disease                                

Name
Acute alcohol sensitivity
Description
Aldehyde dehydrogenases (ALDHs) are important enzymes that eliminate toxic aldehydes by catalysing their oxidation to non-reactive acids. It is reported that a deficiency in the ALDH2 is associated with the alcohol flush reaction. More than 40% of the East Asians population carries a common ALDH2 mutant allele, which results in a dramatic reduction in the enzymatic activity when compared with the wild-type allele.
Category
Inherited metabolic disease
Brite
Human diseases [BR:br08402]
 Congenital disorders of metabolism
  Congenital disorders of carbohydrate metabolism
   H01071  Acute alcohol sensitivity
BRITE hierarchy
Pathway
Glycolysis / Gluconeogenesis
Gene
ALDH2 [HSA:217] [KO:K00128]
Other DBs
OMIM: 
Reference
  Authors
Dickson PA, James MR, Heath AC, Montgomery GW, Martin NG, Whitfield JB, Birley AJ
  Title
Effects of variation at the ALDH2 locus on alcohol metabolism, sensitivity, consumption, and dependence in Europeans.
  Journal
Alcohol Clin Exp Res 30:1093-100 (2006)
DOI:10.1111/j.1530-0277.2006.00128.x
Reference
  Authors
Chen CH, Sun L, Mochly-Rosen D
  Title
Mitochondrial aldehyde dehydrogenase and cardiac diseases.
  Journal
Cardiovasc Res 88:51-7 (2010)
DOI:10.1093/cvr/cvq192

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