KEGG   DISEASE: H01102Help
H01102                      Disease                                

Pituitary adenomas, including:
Multiple endocrine neoplasia type 1 (MEN1);
MEN1-like syndrome (MEN4);
Carney complex (CNC);
Familial isolated pituitary adenomas (FIPA)
Pituitary adenomas are an important and frequently occurring form of intracranial tumour. They are usually benign but can give rise to severe clinical syndromes due to hormonal excess, or to visual/cranial disturbances due to mass effect. The tumour can be clinically nonfunctioning or hormone secreting. Among the latter, prolactin (PRL) and growth hormone (GH)-secreting adenomas are the most common. The majority of pituitary adenomas arise sporadically, although a subset occurs as component tumors of well-characterized familial cancer syndromes, such as multiple endocrine neoplasia type 1 (MEN1), Carney complex, and MEN1-like syndrome (MEN4). It has been described non-MEN/CNC familial pituitary tumours that include all tumour phenotypes as a condition named familial isolated pituitary adenomas (FIPA).
Nervous system disease; Endocrine disease; Cancer
BRITE hierarchy
Transcriptional misregulation in cancer
ErbB signaling pathway
Cell cycle
Insulin signaling pathway
(MEN1) MEN1 [HSA:4221] [KO:K14970]
(MEN4) CDKN1B [HSA:1027] [KO:K06624]
(CNC) PRKAR1A [HSA:5573] [KO:K04739]
(FIPA) AIP [HSA:9049] [KO:K17767]
Other DBs
PMID:21454441 (description, gene)
Trivellin G, Korbonits M
AIP and its interacting partners.
J Endocrinol 210:137-55 (2011)
PMID:20956458 (description, gene)
Heliovaara E, Tuupanen S, Ahlsten M, Hodgson S, de Menis E, Kuismin O, Izatt L, McKinlay Gardner RJ, Gundogdu S, Lucassen A, Arola J, Tuomisto A, Makinen M, Karhu A, Aaltonen LA
No evidence of RET germline mutations in familial pituitary adenoma.
J Mol Endocrinol 46:1-8 (2011)
PMID:19522822 (description, gene)
Tichomirowa MA, Daly AF, Beckers A
Familial pituitary adenomas.
J Intern Med 266:5-18 (2009)

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