KEGG   DISEASE: H01102Help
Entry
H01102                      Disease                                

Name
Pituitary adenomas, including:
Multiple endocrine neoplasia type 1 (MEN1);
MEN1-like syndrome (MEN4);
Carney complex (CNC);
Familial isolated pituitary adenomas (FIPA)
Description
Pituitary adenomas are an important and frequently occurring form of intracranial tumour. They are usually benign but can give rise to severe clinical syndromes due to hormonal excess, or to visual/cranial disturbances due to mass effect. The tumour can be clinically nonfunctioning or hormone secreting. Among the latter, prolactin (PRL) and growth hormone (GH)-secreting adenomas are the most common. The majority of pituitary adenomas arise sporadically, although a subset occurs as component tumors of well-characterized familial cancer syndromes, such as multiple endocrine neoplasia type 1 (MEN1), Carney complex, and MEN1-like syndrome (MEN4). It has been described non-MEN/CNC familial pituitary tumours that include all tumour phenotypes as a condition named familial isolated pituitary adenomas (FIPA).
Category
Nervous system disease; Endocrine disease; Cancer
BRITE hierarchy
Pathway
Transcriptional misregulation in cancer
ErbB signaling pathway
Cell cycle
Apoptosis
Insulin signaling pathway
Gene
(MEN1) MEN1 [HSA:4221] [KO:K14970]
(MEN4) CDKN1B [HSA:1027] [KO:K06624]
(CNC) PRKAR1A [HSA:5573] [KO:K04739]
(FIPA) AIP [HSA:9049] [KO:K17767]
Other DBs
Reference
PMID:21454441 (description, gene)
  Authors
Trivellin G, Korbonits M
  Title
AIP and its interacting partners.
  Journal
J Endocrinol 210:137-55 (2011)
Reference
PMID:20956458 (description, gene)
  Authors
Heliovaara E, Tuupanen S, Ahlsten M, Hodgson S, de Menis E, Kuismin O, Izatt L, McKinlay Gardner RJ, Gundogdu S, Lucassen A, Arola J, Tuomisto A, Makinen M, Karhu A, Aaltonen LA
  Title
No evidence of RET germline mutations in familial pituitary adenoma.
  Journal
J Mol Endocrinol 46:1-8 (2011)
Reference
PMID:19522822 (description, gene)
  Authors
Tichomirowa MA, Daly AF, Beckers A
  Title
Familial pituitary adenomas.
  Journal
J Intern Med 266:5-18 (2009)

» Japanese version

DBGET integrated database retrieval system