KEGG   DISEASE: H01171Help
Entry
H01171                      Disease                                

Name
Poor drug metabolism (PM)
Description
Many administered drugs are first activated by phase I drug-metabolizing enzymes, such as cytochrome P450 (CYP). There are some defective activity mutants due to CYP polymorphisms. In these cases, drugs are not metabolized, the high drug levels in blood are maintained, and toxic effects appear in the patients.
Category
Inherited metabolic disease
BRITE hierarchy
Pathway
Drug metabolism - cytochrome P450
Gene
CYP2C19 [HSA:1557] [KO:K17721]
CYP2D6 [HSA:1565] [KO:K17712]
Comment
In Caucasians and Asians, PM and allele frequency levels of CYPs (CYP2A6, CYP2C9, CYP2C19, CYP2D6, and CYP3A4) are summarized from previous findings.
Other DBs
Reference
  Authors
Mizutani T
  Title
PM frequencies of major CYPs in Asians and Caucasians.
  Journal
Drug Metab Rev 35:99-106 (2003)
Reference
  Authors
Gaikovitch EA, Cascorbi I, Mrozikiewicz PM, Brockmoller J, Frotschl R, Kopke K, Gerloff T, Chernov JN, Roots I
  Title
Polymorphisms of drug-metabolizing enzymes CYP2C9, CYP2C19, CYP2D6, CYP1A1, NAT2  and of P-glycoprotein in a Russian population.
  Journal
Eur J Clin Pharmacol 59:303-12 (2003)
Reference
PMID:9093256
  Authors
Kaneko A, Kaneko O, Taleo G, Bjorkman A, Kobayakawa T
  Title
High frequencies of CYP2C19 mutations and poor metabolism of proguanil in Vanuatu.
  Journal
Lancet 349:921-2 (1997)

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