KEGG   DISEASE: H01205Help
Entry
H01205                      Disease                                

Name
Coumarin resistance;
Warfarin resistance
Description
Warfarin is widely prescribed anticoagulant for the prevention of thromboembolic diseases. However, its use is made difficult by the wide interindividual variation in dose required to achieve a therapeutic effect, the narrow therapeutic range, and the risk of serious bleeding. Warfarin dose requirement is influenced by factors such as intake of vitamin K, ethnicity, age, gender, and genetic factors. Warfarin acts through interference with the recycling of vitamin K in the liver. It has been reported that mutations in VKORC1, CYP2C9, and GGCX cause warfarin resistance.
Category
Inherited metabolic disease
BRITE hierarchy
Pathway
Drug metabolism - cytochrome P450
Gene
VKORC1 [HSA:79001] [KO:K05357]
CYP2C9 [HSA:1559] [KO:K17719]
GGCX [HSA:2677] [KO:K10106]
Drug
Warfarine [DR:D08682]
Other DBs
MeSH: 
OMIM: 
Reference
  Authors
Osinbowale O, Al Malki M, Schade A, Bartholomew JR
  Title
An algorithm for managing warfarin resistance.
  Journal
Cleve Clin J Med 76:724-30 (2009)
Reference
  Authors
Wadelius M, Chen LY, Eriksson N, Bumpstead S, Ghori J, Wadelius C, Bentley D, McGinnis R, Deloukas P
  Title
Association of warfarin dose with genes involved in its action and metabolism.
  Journal
Hum Genet 121:23-34 (2007)

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