KEGG   DISEASE: Inflammatory bowel disease (IBD)Help
H01227                      Disease                                

Inflammatory bowel disease (IBD)
Crohn's disease [DS:H00286]
Ulcerative colitis [DS:H01466]
Inflammatory bowel disease is a heterogeneous group of chronic disorders, which includes Crohn's disease and ulcerative colitis. Patients suffer chronically from abdominal pain, diarrhea, bleeding, and malabsorption. In most patients, these disorders are manifested in adolescence or adulthood, however, they may present in infancy and may be inherited as an autosomal recessive trait. It has been reported that mutations in genes encoding the IL10R subunit proteins were found in patients with early-onset enterocolitis, involving hyperinflammatory immune responses in the intestine. Additional genes associated with the disease have been identified.
Immune system disease
Human diseases [BR:br08402]
 Immune system diseases
  Other immune system diseases
   H01227  Inflammatory bowel disease
BRITE hierarchy
hsa04612 NOD-like receptor signaling pathway  
hsa04060 Cytokine-cytokine receptor interaction  
hsa04630 Jak-STAT signaling pathway  
hsa05321 Inflammatory bowel disease  
hsa04140 Regulation of autophagy  
(IBD1) NOD2 (polymorphism) [HSA:64127] [KO:K10165]
(IBD10) ATG16L1 (polymorphism) [HSA:55054] [KO:K17890]
(IBD13) ABCB1 (polymorphism) [HSA:5243] [KO:K05658]
(IBD14) IRF5 (polymorphism) [HSA:3663] [KO:K09446]
(IBD17) IL23R (polymorphism) [HSA:149233] [KO:K05065]
(IBD19) IRGM (polymorphism) [HSA:345611] [KO:K14139]
(IBD25) IL10RB [HSA:3588] [KO:K05135]
(IBD28) IL10RA [HSA:3587] [KO:K05134]
IL10 (polymorphism) [HSA:3586] [KO:K05443]
MST1 (polymorphism) [HSA:4485]
Other DBs
Hugot JP, Chamaillard M, Zouali H, Lesage S, Cezard JP, Belaiche J, Almer S, Tysk C, O'Morain CA, Gassull M, Binder V, Finkel Y, Cortot A, Modigliani R, Laurent-Puig P, Gower-Rousseau C, Macry J, Colombel JF, Sahbatou M, Thomas G
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease.
Nature 411:599-603 (2001)
Glocker EO, Kotlarz D, Boztug K, Gertz EM, Schaffer AA, Noyan F, Perro M, Diestelhorst J, Allroth A, Murugan D, Hatscher N, Pfeifer D, Sykora KW, Sauer M, Kreipe H, Lacher M, Nustede R, Woellner C, Baumann U, Salzer U, Koletzko S, Shah N, Segal AW, Sauerbrey A, Buderus S, Snapper SB, Grimbacher B, Klein C
Inflammatory bowel disease and mutations affecting the interleukin-10 receptor.
N Engl J Med 361:2033-45 (2009)
Glocker EO, Kotlarz D, Klein C, Shah N, Grimbacher B
IL-10 and IL-10 receptor defects in humans.
Ann N Y Acad Sci 1246:102-7 (2011)
PMID:19923578 (gene)
Abraham C, Cho JH
Inflammatory bowel disease.
N Engl J Med 361:2066-78 (2009)
PMID:26339135 (drug)
de Mattos BR, Garcia MP, Nogueira JB, Paiatto LN, Albuquerque CG, Souza CL, Fernandes LG, Tamashiro WM, Simioni PU
Inflammatory Bowel Disease: An Overview of Immune Mechanisms and Biological Treatments.
Mediators Inflamm 2015:493012 (2015)
PMID:26600980 (drug)
Akiho H, Yokoyama A, Abe S, Nakazono Y, Murakami M, Otsuka Y, Fukawa K, Esaki M, Niina Y, Ogino H
Promising biological therapies for ulcerative colitis: A review of the literature.
World J Gastrointest Pathophysiol 6:219-27 (2015)
PMID:26284562 (drug)
Danese S, Vuitton L, Peyrin-Biroulet L
Biologic agents for IBD: practical insights.
Nat Rev Gastroenterol Hepatol 12:537-45 (2015)

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