KEGG   DISEASE: Inflammatory bowel disease (IBD)Help
Entry
H01227                      Disease                                

Name
Inflammatory bowel disease (IBD)
Description
Inflammatory bowel disease is a heterogeneous group of chronic disorders, which includes Crohn's disease and ulcerative colitis. Patients suffer chronically from abdominal pain, diarrhea, bleeding, and malabsorption. In most patients, these disorders are manifested in adolescence or adulthood, however, they may present in infancy and may be inherited as an autosomal recessive trait. It has been reported that mutations in genes encoding the IL10R subunit proteins were found in patients with early-onset enterocolitis, involving hyperinflammatory immune responses in the intestine. Additional genes associated with the disease have been identified.
Category
Immune system disease
Brite
Human diseases [BR:br08402]
 Immune system diseases
  Other immune system diseases
   H01227  Inflammatory bowel disease
BRITE hierarchy
Pathway
hsa04612 NOD-like receptor signaling pathway  
 
hsa04060 Cytokine-cytokine receptor interaction  
 
hsa04630 Jak-STAT signaling pathway  
 
hsa05321 Inflammatory bowel disease  
 
hsa04140 Regulation of autophagy  
 
Gene
NOD2 (polymorphysm) [HSA:64127] [KO:K10165]
ATG16L1 (polymorphysm) [HSA:55054] [KO:K17890]
IL23R (polymorphysm) [HSA:149233] [KO:K05065]
IL10RB [HSA:3588] [KO:K05135]
IL10RA [HSA:3587] [KO:K05134]
IL10 (polymorphsm) [HSA:3586] [KO:K05443]
MST1 (polymorphysm) [HSA:4485]
IRGM (polymorphysm) [HSA:345611] [KO:K14139]
Marker
Ulcerative colitisis: Superficial inflammation of the colonic mucosa, beginning in the rectum and extending proximally
Drug
Infliximab [DR:D02598] Golimumab [DR:D04358] Adalimuab [DR:D02597] Certolizumab pegol [DR:D03441] (anti-TNF-alpha agents)
Vedolizumab [DR:D08083] Natalizumab [DR:D06886] (anti-integrin agents)
Mesalzine [DR:D00377] Salazosulfapyridine [DR:D00448] Balsalazide disodium [DR:D02715] Olsalazine sodium [DR:D00727] (Aminosalicylates)
Budesonide [DR:D00246] Prednisolone [DG:DG00093] (Corticosteroids)
Comment
Crohn's disease is described in H00286. [DS:H00286]
Ulcerative colitis is described in H01466. [DS:H01466]
Other DBs
Reference
  Authors
Hugot JP, Chamaillard M, Zouali H, Lesage S, Cezard JP, Belaiche J, Almer S, Tysk C, O'Morain CA, Gassull M, Binder V, Finkel Y, Cortot A, Modigliani R, Laurent-Puig P, Gower-Rousseau C, Macry J, Colombel JF, Sahbatou M, Thomas G
  Title
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease.
  Journal
Nature 411:599-603 (2001)
Reference
  Authors
Glocker EO, Kotlarz D, Boztug K, Gertz EM, Schaffer AA, Noyan F, Perro M, Diestelhorst J, Allroth A, Murugan D, Hatscher N, Pfeifer D, Sykora KW, Sauer M, Kreipe H, Lacher M, Nustede R, Woellner C, Baumann U, Salzer U, Koletzko S, Shah N, Segal AW, Sauerbrey A, Buderus S, Snapper SB, Grimbacher B, Klein C
  Title
Inflammatory bowel disease and mutations affecting the interleukin-10 receptor.
  Journal
N Engl J Med 361:2033-45 (2009)
Reference
  Authors
Glocker EO, Kotlarz D, Klein C, Shah N, Grimbacher B
  Title
IL-10 and IL-10 receptor defects in humans.
  Journal
Ann N Y Acad Sci 1246:102-7 (2011)
Reference
PMID:19923578 (gene)
  Authors
Abraham C, Cho JH
  Title
Inflammatory bowel disease.
  Journal
N Engl J Med 361:2066-78 (2009)
Reference
PMID:26339135 (drug)
  Authors
de Mattos BR, Garcia MP, Nogueira JB, Paiatto LN, Albuquerque CG, Souza CL, Fernandes LG, Tamashiro WM, Simioni PU
  Title
Inflammatory Bowel Disease: An Overview of Immune Mechanisms and Biological Treatments.
  Journal
Mediators Inflamm 2015:493012 (2015)
Reference
PMID:26600980 (drug)
  Authors
Akiho H, Yokoyama A, Abe S, Nakazono Y, Murakami M, Otsuka Y, Fukawa K, Esaki M, Niina Y, Ogino H
  Title
Promising biological therapies for ulcerative colitis: A review of the literature.
  Journal
World J Gastrointest Pathophysiol 6:219-27 (2015)
Reference
PMID:26284562 (drug)
  Authors
Danese S, Vuitton L, Peyrin-Biroulet L
  Title
Biologic agents for IBD: practical insights.
  Journal
Nat Rev Gastroenterol Hepatol 12:537-45 (2015)

» Japanese version

DBGET integrated database retrieval system