KEGG   DISEASE: H01260Help
Entry
H01260                      Disease                                

Name
Glomerulopathy with fibronectin deposits (GFND)
Description
Glomerulopathy with fibronectin deposits (GFND) is a hereditary kidney disease with proteinuria, microscopic hematuria, and hypertension that lead to end-stage renal failure in the second to sixth decade of life. It has been reported that mutations in FN1, which encodes fibronectin, are the cause of GFND.
Category
Kidney disease
BRITE hierarchy
Pathway
Focal adhesion
ECM-receptor interaction
Regulation of actin cytoskeleton
Gene
FN1 [HSA:2335] [KO:K05717]
Other DBs
ICD-10: 
MeSH: 
OMIM: 
Reference
  Authors
Castelletti F, Donadelli R, Banterla F, Hildebrandt F, Zipfel PF, Bresin E, Otto E, Skerka C, Renieri A, Todeschini M, Caprioli J, Caruso RM, Artuso R, Remuzzi G, Noris M
  Title
Mutations in FN1 cause glomerulopathy with fibronectin deposits.
  Journal
Proc Natl Acad Sci U S A 105:2538-43 (2008)

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