KEGG   DISEASE: H01274Help
Entry
H01274                      Disease                                

Name
Growth delay due to insulin-like growth factor I resistance;
IGF-I resistance
Description
Growth delay due to IGF-I resistance is characterised by variable prenatal and postnatal growth retardation and elevated serum IGF-I levels. It has been described that the defects in the IGF-IR gene cause postnatal growth failure.
Category
Endocrine disease
BRITE hierarchy
Pathway
Oocyte meiosis
Focal adhesion
Adherens junction
Long-term depression
Progesterone-mediated oocyte maturation
Gene
IGF1R [HSA:3480] [KO:K05087]
Other DBs
ICD-10: 
MeSH: 
OMIM: 
Reference
  Authors
Abuzzahab MJ, Schneider A, Goddard A, Grigorescu F, Lautier C, Keller E, Kiess W, Klammt J, Kratzsch J, Osgood D, Pfaffle R, Raile K, Seidel B, Smith RJ, Chernausek SD
  Title
IGF-I receptor mutations resulting in intrauterine and postnatal growth retardation.
  Journal
N Engl J Med 349:2211-22 (2003)
Reference
  Authors
Kawashima Y, Kanzaki S, Yang F, Kinoshita T, Hanaki K, Nagaishi J, Ohtsuka Y, Hisatome I, Ninomoya H, Nanba E, Fukushima T, Takahashi S
  Title
Mutation at cleavage site of insulin-like growth factor receptor in a short-stature child born with intrauterine growth retardation.
  Journal
J Clin Endocrinol Metab 90:4679-87 (2005)

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