| Entry |
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| Name |
Growth delay due to insulin-like growth factor I resistance;
IGF-I resistance
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| Description |
Growth delay due to IGF-I resistance is characterised by variable prenatal and postnatal growth retardation and elevated serum IGF-I levels. It has been described that the defects in the IGF-IR gene cause postnatal growth failure.
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| Category |
Endocrine system disease
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| Pathway |
| Oocyte meiosis | | Focal adhesion | | Adherens junction | | Long-term depression | | Progesterone-mediated oocyte maturation |
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| Gene |
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| Other DBs |
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| Reference |
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| Authors |
Abuzzahab MJ, Schneider A, Goddard A, Grigorescu F, Lautier C, Keller E, Kiess W, Klammt J, Kratzsch J, Osgood D, Pfaffle R, Raile K, Seidel B, Smith RJ, Chernausek SD |
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| Title |
IGF-I receptor mutations resulting in intrauterine and postnatal growth retardation. |
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| Journal |
N Engl J Med 349:2211-22 (2003) |
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| Reference |
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| Authors |
Kawashima Y, Kanzaki S, Yang F, Kinoshita T, Hanaki K, Nagaishi J, Ohtsuka Y, Hisatome I, Ninomoya H, Nanba E, Fukushima T, Takahashi S |
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| Title |
Mutation at cleavage site of insulin-like growth factor receptor in a short-stature child born with intrauterine growth retardation. |
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| Journal |
J Clin Endocrinol Metab 90:4679-87 (2005) |
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