KEGG   DISEASE: H01287Help
H01287                      Disease                                

Congenital mirror movements (CMM)
Mirror movements are involuntary movements of one side of the body that mirror intentional movements on the opposite side. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Congenital mirror movements (CMM) is a rare disorder that is mainly inherited in an autosomal-dominant fashion. Mutations in DCC, the gene encoding receptor for netrin 1 have been identified in CMM patients. It has also been reported that RAD51 haploinsufficiency causes the heterogeneous CMM.
Nervous system disease
Human diseases [BR:br08402]
 Nervous system diseases
  Other nervous and sensory system diseases
   H01287  Congenital mirror movements (CMM)
BRITE hierarchy
Axon guidance
Homologous recombination
DCC [HSA:1630] [KO:K06765]
RAD51A [HSA:5888] [KO:K04482]
Other DBs
Srour M, Riviere JB, Pham JM, Dube MP, Girard S, Morin S, Dion PA, Asselin G, Rochefort D, Hince P, Diab S, Sharafaddinzadeh N, Chouinard S, Theoret H, Charron F, Rouleau GA
Mutations in DCC cause congenital mirror movements.
Science 328:592 (2010)
Depienne C, Bouteiller D, Meneret A, Billot S, Groppa S, Klebe S, Charbonnier-Beaupel F, Corvol JC, Saraiva JP, Brueggemann N, Bhatia K, Cincotta M, Brochard V, Flamand-Roze C, Carpentier W, Meunier S, Marie Y, Gaussen M, Stevanin G, Wehrle R, Vidailhet M, Klein C, Dusart I, Brice A, Roze E
RAD51 haploinsufficiency causes congenital mirror movements in humans.
Am J Hum Genet 90:301-7 (2012)

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