KEGG DISEASE: Non-Hodgkin lymphoma

DISEASE: Non-Hodgkin lymphoma

Entry

H02418                      Disease

Name

Non-Hodgkin lymphoma

Subgroup

Chronic lymphocytic leukemia [DS:H00005]
Lymphoplasmacytic lymphoma [DS:H00011]
Hairy cell leukemia [DS:H00006]
Follicular lymphoma [DS:H01613]
Mantle cell lymphoma [DS:H01464]
Burkitt lymphoma [DS:H00008]
Peripheral T cell lymphoma [DS:H01892]
B-cell acute lymphoblastic leukemia [DS:H00001]
Mycosis fungoides [DS:H01463]
Anaplastic large-cell lymphoma [DS:H01601]
Diffuse large B-cell lymphoma, not otherwise specified [DS:H02434]

Description

Non-Hodgkin lymphoma (NHL) is one of the most common hematologic malignancies worldwide. NHL includes malignant tumors of the lymphoid tissues variously resulting from the clonal growth of B cells, T cells and natural killer cells. NHL can be broadly classified based on the type of lymphocyte involved: B lymphocyte (B cell) or T lymphocyte (T cell) and is further classified by other factors, including whether it is aggressive or indolent. Aggressive NHL is fast-growing disease. It mainly includes mantle cell lymphoma, diffuse large B-cell lymphoma, Burkitt's lymphoma, lymphoblastic lymphoma and peripheral T-cell lymphoma. On the other hand, indolent NHL is slow-growing disease. It mainly includes follicular lymphoma, cutaneous T-cell lymphoma, lymphoplasmacytic lymphoma and MALT lymphoma.

Category

Cancer

Brite

Human diseases in ICD-11 classification [BR:br08403]
02 Neoplasms
  Neoplasms of haematopoietic or lymphoid tissues
   2B33  Malignant haematopoietic neoplasms without further specification
    H02418  Non-Hodgkin lymphoma
Pathway-based classification of diseases [BR:br08402]
Replication and repair
  nt06506  Double-strand break repair
   H02418  Non-Hodgkin lymphoma

Pathway

hsa03440

Homologous recombination

hsa04210

Apoptosis

Network

nt06506 Double-strand break repair

Gene

RAD54L [HSA:8438] [KO:K10875]
RAD54B [HSA:25788] [KO:K10877]
CASP10 [HSA:843] [KO:K04400]
PRF1 [HSA:5551] [KO:K07818]

Drug

Bendamustine hydrochloride [DR:D07085]
Carmustine [DR:D00254]
Methotrexate sodium [DR:D02115]
Vincristine sulfate [DR:D02197]
Doxorubicin hydrochloride [DR:D01275]
Bleomycin sulfate [DR:D02177]
Rituximab [DR:D02994] (CD20-positive)
Plerixafor [DR:D08971]

Other DBs

ICD-11:

ICD-10:

MeSH:

OMIM:

Reference

PMID:10362365 (RAD54L)

Authors

Matsuda M, Miyagawa K, Takahashi M, Fukuda T, Kataoka T, Asahara T, Inui H, Watatani M, Yasutomi M, Kamada N, Dohi K, Kamiya K

Title

Mutations in the RAD54 recombination gene in primary cancers.

Journal

Oncogene 18:3427-30 (1999)
DOI:10.1038/sj.onc.1202692

Reference

PMID:10362364 (RAD54B)

Authors

Hiramoto T, Nakanishi T, Sumiyoshi T, Fukuda T, Matsuura S, Tauchi H, Komatsu K, Shibasaki Y, Inui H, Watatani M, Yasutomi M, Sumii K, Kajiyama G, Kamada N, Miyagawa K, Kamiya K

Title

Mutations of a novel human RAD54 homologue, RAD54B, in primary cancer.

Journal

Oncogene 18:3422-6 (1999)
DOI:10.1038/sj.onc.1202691

Reference

PMID:12010812 (CASP10)

Authors

Shin MS, Kim HS, Kang CS, Park WS, Kim SY, Lee SN, Lee JH, Park JY, Jang JJ, Kim CW, Kim SH, Lee JY, Yoo NJ, Lee SH

Title

Inactivating mutations of CASP10 gene in non-Hodgkin lymphomas.

Journal

Blood 99:4094-9 (2002)
DOI:10.1182/blood.v99.11.4094

Reference

PMID:15728124 (PRF1)

Authors

Clementi R, Locatelli F, Dupre L, Garaventa A, Emmi L, Bregni M, Cefalo G, Moretta A, Danesino C, Comis M, Pession A, Ramenghi U, Maccario R, Arico M, Roncarolo MG

Title

A proportion of patients with lymphoma may harbor mutations of the perforin gene.

Journal

Blood 105:4424-8 (2005)
DOI:10.1182/blood-2004-04-1477

» Japanese version

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Network (3)   
   KEGG NETWORK (1)   
   KEGG VARIANT (2)   
Disease (1)   
   OMIM (1)   
Drug (10)   
   KEGG DRUG (10)   
Gene (8)   
   KEGG ORTHOLOGY (4)   
   KEGG GENES (4)   
Literature (4)   
   PubMed (4)   
All databases (26)   

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