KEGG   Equus asinus (ass): 106844524Help
Entry
106844524         CDS       T04645                                 

Gene name
INSR
Definition
(RefSeq) insulin receptor
  KO
K04527  
insulin receptor [EC:2.7.10.1]
Organism
eai  Equus asinus (ass)
Pathway
MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phospholipase D signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Longevity regulating pathway
Longevity regulating pathway - multiple species
Adherens junction
Insulin signaling pathway
Ovarian steroidogenesis
Regulation of lipolysis in adipocytes
Type II diabetes mellitus
Insulin resistance
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Module
PI3K-Akt signaling
Brite
KEGG Orthology (KO) [BR:eai00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    106844524 (INSR)
   04015 Rap1 signaling pathway
    106844524 (INSR)
   04010 MAPK signaling pathway
    106844524 (INSR)
   04066 HIF-1 signaling pathway
    106844524 (INSR)
   04068 FoxO signaling pathway
    106844524 (INSR)
   04072 Phospholipase D signaling pathway
    106844524 (INSR)
   04022 cGMP - PKG signaling pathway
    106844524 (INSR)
   04151 PI3K-Akt signaling pathway
    106844524 (INSR)
   04152 AMPK signaling pathway
    106844524 (INSR)
   04150 mTOR signaling pathway
    106844524 (INSR)
 Cellular Processes
  Cellular community - eukaryotes
   04520 Adherens junction
    106844524 (INSR)
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    106844524 (INSR)
   04923 Regulation of lipolysis in adipocyte
    106844524 (INSR)
   04913 Ovarian Steroidogenesis
    106844524 (INSR)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    106844524 (INSR)
  Aging
   04211 Longevity regulating pathway - mammal
    106844524 (INSR)
   04213 Longevity regulating pathway - multiple species
    106844524 (INSR)
 Human Diseases
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    106844524 (INSR)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    106844524 (INSR)
   04931 Insulin resistance
    106844524 (INSR)
Enzymes [BR:eai01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     106844524 (INSR)
Protein kinases [BR:eai01001]
 Tyrosine protein kinases
  InsR family [OT]
   106844524 (INSR)
Enzyme-linked receptors [BR:eai01020]
 Receptor tyrosine kinases
  RTK class II (Insulin receptor family)
   106844524 (INSR)
Cytokine receptors [BR:eai04050]
 Receptor tyrosine kinase
  RTK class II (Insulin receptor family)
   106844524 (INSR)
CD molecules [BR:eai04090]
 Proteins
  106844524 (INSR)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
Position
Un
AA seq 1344 aa AA seqDB search
MDIRNNLTRLHELANCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLE
SLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLAT
IDWSRILDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQK
VCPTICKSHGCTADGLCCHSECLGNCSEPDDPTKCVACRNFYLDGRCVETCPPPYYHFQD
WRCVNFSFCQDLHNKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLMCTPCLGPCPK
VCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKI
RRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHY
NPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLTFSHIRTSSDKILLKWE
PYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPG
WLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTNATNPSVPLDPISVSNSSSQ
IILKWKPPSDPNGNITHYLVFWERQEEDSELYELDYCLKGLKLPSRTWSPPFESEGSQKH
NQSEYEESAGECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVPRKSSSGPGAEDTRP
SRKRRALADVGNVTVAVPTVPGFPNTSSTSTPTSSEERRPFEKVVNKESLVISGLRHFTG
YRIELQACNQDSPEERCSVAAYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEP
NGLIVLYEVSYRRYGDEELHLCVSRRHFALERGCRLRGLPPGNYSVRVRATSLAGNGSWT
EATYFYVTDYYVPSNIAKIIIGPLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPE
YLSASDVFPCSVYVPDEWEVPREKITLLRELGQGSFGMVYEGNARDIVKGEAETRVAVKT
VNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSL
RPEAENNPGRPPPTLQEMVQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDF
GMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQ
GLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVDLLKDDLHPSF
PEVSFFHSEENKAPESEELEMEFEDMENVPLDRSSHSQREEAGGRDAGSSLGLKRNYEEH
IPYTHMNGGKKNGRILTLPRSNPS
NT seq 4035 nt NT seq  +upstreamnt  +downstreamnt
atggatatccggaacaacctcacgaggctgcacgagctggccaactgctccgtcattgaa
ggacacttgcagattctgttgatgtttaaaacgaggcctgaggatttccgagacctcagt
ttccccaaactcatcatgatcactgattacttgctgctcttccgggtgtacgggctggag
agcctgaaggacctgttccccaacctcacggtcatccggggctctcgcctcttcttcaac
tacgcgctggtcatcttcgagatggttcacctgaaggagcttggcctctacaacctgatg
aacatcacccgcggctccgtccgcatcgagaagaacaacgagctgtgctacctggccacc
attgactggtcgcgcattctggactcggtggaagataattacatcgtgctgaacaaggac
gacaatgaggagtgcggggacatttgtccaggcaccgccaagggcaagaccaactgcccc
gctactgtcatcaacggacagtttgttgagcggtgctggacgcacagccattgccagaaa
gtttgcccgaccatctgtaagtcacacggctgcaccgcggacggcctctgctgccacagc
gagtgtttaggcaactgctctgagcccgacgaccccaccaagtgcgtggcctgccgcaac
ttctacctggacggcaggtgtgtggagacctgcccgcccccgtactatcacttccaagac
tggcgctgtgtgaacttcagcttctgccaggacctgcacaacaaatgcaagaactcccga
aggcagggctgccatcagtacgtcattcacaacaacaagtgcatccctgagtgtccctct
gggtacacgatgaattccagcaacttgatgtgtaccccgtgcctgggtccctgtcccaag
gtgtgccacctcctggaaggcgagaagaccatcgactcggtgacgtccgcccaggagctc
cgaggctgcacggtcatcaacgggagcctgatcatcaacatccgagggggcaacaacctg
gcagctgagctagaggccaacctcggactcattgaagaaatttcagggtatctgaaaatc
cgccggtcctacgctctcgtgtcgctttccttcttccggaagttacgcctaattcgggga
gagaccttggaaatcgggaactactcattctacgccttggacaaccagaacctgaggcag
ctatgggactggagcaagcacaacctcaccatcactcaggggaaactcttcttccactat
aatcccaaactctgcttgtcggaaattcacaagatggaggaagtttcaggaaccaaaggg
cgccaggagaggaacgacatcgccctgaagaccaacggggaccaggcatcctgtgaaaat
gagttacttacattttctcacattcggacatcttctgacaagatcttgctgaaatgggag
ccgtattggccccccgacttccgagacctcttgggcttcatgctcttctataaagaggcc
ccttatcagaacgtgacggagttcgatgggcaggatgcgtgtggctccaacagctggacg
gtagtggacattgacccacctctgaggtccaacgaccccaagtcacagaaccaccctggg
tggctgatgcgaggtctcaaaccctggacccagtacgccatctttgtcaagaccttggtc
accttttctgatgaacgccggacatacggggccaagagcgacatcatctatgtccagaca
aatgccacgaacccgtctgtccccctggatcccatctccgtttctaattcctcgtcccag
attattctgaaatggaagcccccctctgaccccaatgggaacatcacacactacctggtt
ttctgggagaggcaggaggaagacagcgagctgtacgagttggattattgcctcaaaggc
ttgaagctgccctccaggacctggtctccaccgtttgagtctgaggggtcccagaagcac
aatcagagtgagtacgaggagtctgccggcgaatgctgctcctgcccgaagaccgactcc
cagatcctgaaggagctggaggagtcctcgttcaggaagacgttcgaggactatctgcac
aatgtggtttttgtccccagaaaatcctcttcaggccctggtgccgaggacactagaccg
tctcggaaacgcagggcgcttgctgatgtcgggaatgtgacggtggccgtgcccacggtt
ccgggtttccctaatacctcctccaccagcacgcccacgagctcagaggagcgcagaccc
ttcgagaaagtggtgaacaaggagtcgctggtcatctccggcctgcgccattttaccggc
tatcgcatcgagcttcaggcttgcaaccaagattcccccgaagagaggtgcagtgtggct
gcctatgtcagtgccaggaccatgcccgaagccaaggcggacgacatcgttggccccgtg
actcacgaaatcttcgagaacaatgtcgttcacttgatgtggcaggagcccaaagaaccc
aacggtctgattgtgctgtacgaagtgagttatcgacgatacggcgatgaggagctgcat
ctctgtgtgtctcgcagacattttgccctggagcggggctgccggctgcgcgggctgcca
ccggggaactacagtgtgcgagtgcgggccacctccctggcaggcaacggctcctggacc
gaagccacttatttctacgtgacagactattacgtcccatcaaatattgcaaaaatcatc
atcggccccctcatctttgtctttctcttcagtgtggtcattggaagcatttacctcttc
ttgagaaagaggcagccggatgggcccctgggaccgctgtacgcttcctcaaaccctgag
tacctcagcgccagtgatgtgtttccctgctctgtgtacgtgccggacgagtgggaggtg
cctcgggagaagatcaccctcctgcgggagctggggcagggctccttcggcatggtgtat
gaaggcaacgccagggacatcgtcaagggcgaggcggagacccgcgtggcggtgaagacg
gtcaacgagtctgccagtctgcgagagaggatcgagtttctcaacgaggcctcagtcatg
aagggcttcacctgccatcatgtggtccgcctcctgggggtggtatcgaaaggccagcca
acgctggtggtgatggagttgatggctcacggagacctgaagagctacctccgttccctg
cggccggaggctgagaataaccctggtcgccctccccctaccctgcaagagatggttcag
atggcggcggagatcgccgacgggatggcgtacctgaacgctaagaagtttgtgcaccgg
gacctggcagctcgaaactgcatggtcgcccacgattttaccgtcaaaatcggagacttt
ggaatgaccagagacatctacgaaacggattactaccggaaaggaggcaaggggctgctc
cctgtgaggtggatggctcctgaatccctgaaggacggggtctttactacttcttctgac
atgtggtcctttggcgtggtcctttgggaaatcaccagcttggcagaacagccttaccaa
ggcctgtctaatgagcaggtgttgaaatttgtcatggatggagggtatctggatcaaccc
gacaattgtcccgagagagtcaccgacctgatgcgtatgtgctggcagttcaaccccaag
atgcggccgaccttcctggagatcgtcgacctgctcaaggatgacctgcaccccagcttt
ccagaagtttccttcttccacagcgaggagaacaaggcccccgagagcgaggagctggag
atggagtttgaggacatggagaatgtccccctggatcggtcctcacattcccagagggag
gaggccgggggccgggatgcagggtcctctctgggtctaaagcggaactatgaggaacac
atcccgtacactcacatgaacgggggcaagaaaaacgggcggattctgactctgccgagg
tcaaatccttcctaa

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